SLC6A14

SLC6A14
Identifiers
Aliases	SLC6A14 , BMIQ11, solute carrier family 6 member 14
External IDs	OMIM: 300444 MGI: 1890216 HomoloGene: 38290 GeneCards: SLC6A14
Gene location (Human)
Chr.	X chromosome (human)
End	116,461,458 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	21,608,594 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; lower lobe of lung; ; parotid gland; ; bronchial epithelial cell; ; amniotic fluid; ; minor salivary gland; ; trachea; ; pancreatic epithelial cell; ; sperm; ; visceral pleura;
	Top expressed in
	left colon; ; conjunctival fornix; ; left lung lobe; ; right lung; ; right lung lobe; ; seminal vesicula; ; olfactory epithelium; ; cornea; ; parotid gland; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	symporter activity ; amino acid transmembrane transporter activity ; neurotransmitter:sodium symporter activity ; transporter activity ;
Cellular component	integral component of plasma membrane ; membrane ; brush border membrane ; vesicle ; extracellular exosome ; integral component of membrane ; plasma membrane ;
Biological process	neurotransmitter transport ; amino acid transport ; cellular amino acid metabolic process ; response to toxic substance ; transmembrane transport ; amino acid transmembrane transport ; transport ;
	Sources:Amigo / QuickGO
Orthologs
	11254
	56774
	ENSG00000268104
	ENSMUSG00000031089
	Q9UN76
	Q9JMA9
	NM_007231
	NM_020049
	NP_009162
	NP_064433
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 17, 2023

Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (SLC6A14) is a protein that in humans is encoded by the SLC6A14 gene.^[5]^[6]

Function

SLC6A14 is a member of the Na⁺- and Cl⁻-dependent neurotransmitter transporter family and transports both neutral and cationic amino acids in an Na⁺- and Cl⁻-dependent manner.[supplied by OMIM]^[6]

Related Research Articles

SLC22A5 is a membrane transport protein associated with primary carnitine deficiency. This protein is involved in the active cellular uptake of carnitine. It acts a symporter, moving sodium ions and other organic cations across the membrane along with carnitine. Such polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for the elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Mutations in the SLC22A5 gene cause systemic primary carnitine deficiency, which can lead to heart failure.

Neutral and basic amino acid transport protein rBAT is a protein that in humans is encoded by the SLC3A1 gene.

A neurotransmitter sodium symporter (NSS) (TC# 2.A.22) is type of neurotransmitter transporter that catalyzes the uptake of a variety of neurotransmitters, amino acids, osmolytes and related nitrogenous substances by a solute:Na⁺ symport mechanism. The NSS family is a member of the APC superfamily. Its constituents have been found in bacteria, archaea and eukaryotes.

Excitatory amino acid transporter 3 (EAAT3), is a protein that in humans is encoded by the SLC1A1 gene.

Sialin, also known as H(+)/nitrate cotransporter and H(+)/sialic acid cotransporter, is a protein which in humans is encoded by the SLC17A5 gene.

Neutral amino acid transporter B(0) is a protein that in humans is encoded by the SLC1A5 gene.

Solute carrier family 23 member 1 is a protein that in humans is encoded by the SLC23A1 gene.

High affinity cationic amino acid transporter 1 is a protein that in humans is encoded by the SLC7A1 gene.

Proton-coupled amino acid transporter 1 is a protein that in humans is encoded by the SLC36A1 gene.

Neutral amino acid transporter A is a protein that in humans is encoded by the SLC1A4 gene.

Lipin-1 is a protein that in humans is encoded by the LPIN1 gene.

Y+L amino acid transporter 1 is a protein that in humans is encoded by the SLC7A7 gene.

Cationic amino acid transporter 3 is a protein that in humans is encoded by the SLC7A3 gene.

Sodium-coupled neutral amino acid transporter 1 is a protein that in humans is encoded by the SLC38A1 gene.

Cationic amino acid transporter 4 is a protein that in humans is encoded by the SLC7A4 gene.

Sodium-dependent neutral amino acid transporter B(0)AT1 is a protein that in humans is encoded by the SLC6A19 gene.

Proton-coupled amino acid transporter 2 is a protein which in humans is encoded by the SLC36A2 gene.

Y+L amino acid transporter 2, also known as cationic amino acid transporter, y+ system, is a protein that in humans is encoded by the SLC7A6 gene.

Sodium-dependent neutral amino acid transporter B(0)AT2 is a protein that in humans is encoded by the SLC6A15 gene.

Solute carrier family 7, member 14 is a protein that in humans is encoded by the SLC7A14 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000268104 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031089 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sloan JL, Mager S (Sep 1999). "Cloning and functional expression of a human Na(+) and Cl(−)-dependent neutral and cationic amino acid transporter B(0+)". J Biol Chem. 274 (34): 23740–5. doi: 10.1074/jbc.274.34.23740 . PMID 10446133.
1 2 "Entrez Gene: SLC6A14 solute carrier family 6 (amino acid transporter), member 14".

Ohman M, Oksanen L, Kaprio J, Koskenvuo M, Mustajoki P, Rissanen A, Salmi J, Kontula K, Peltonen L (2000). "Genome-wide scan of obesity in Finnish sibpairs reveals linkage to chromosome Xq24". J. Clin. Endocrinol. Metab. 85 (9): 3183–90. doi: 10.1210/jcem.85.9.6797 . PMID 10999806.
Sloan JL, Grubb BR, Mager S (2003). "Expression of the amino acid transporter ATB 0+ in lung: possible role in luminal protein removal". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (1): L39–49. doi:10.1152/ajplung.00164.2002. PMID 12388375.
Suviolahti E, Oksanen LJ, Ohman M, Cantor RM, Ridderstrale M, Tuomi T, Kaprio J, Rissanen A, Mustajoki P, Jousilahti P, Vartiainen E, Silander K, Kilpikari R, Salomaa V, Groop L, Kontula K, Peltonen L, Pajukanta P (2004). "The SLC6A14 gene shows evidence of association with obesity". J. Clin. Invest. 112 (11): 1762–72. doi:10.1172/JCI17491. PMC 281637 . PMID 14660752.
Durand E, Boutin P, Meyre D, Charles MA, Clement K, Dina C, Froguel P (2004). "Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians". Diabetes. 53 (9): 2483–6. doi: 10.2337/diabetes.53.9.2483 . PMID 15331564.
Gupta N, Miyauchi S, Martindale RG, Herdman AV, Podolsky R, Miyake K, Mager S, Prasad PD, Ganapathy ME, Ganapathy V (2005). "Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans". Biochim. Biophys. Acta. 1741 (1–2): 215–23. doi:10.1016/j.bbadis.2005.04.002. PMID 15905073.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000268104 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031089 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10446133-5] Sloan JL, Mager S (Sep 1999). "Cloning and functional expression of a human Na(+) and Cl(−)-dependent neutral and cationic amino acid transporter B(0+)". J Biol Chem. 274 (34): 23740–5. doi: 10.1074/jbc.274.34.23740 . PMID 10446133.

[entrez-6] 1 2 "Entrez Gene: SLC6A14 solute carrier family 6 (amino acid transporter), member 14".

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SLC6A14

Contents

Function

Related Research Articles

References

Further reading