SLC26A6

Last updated
SLC26A6
Identifiers
Aliases SLC26A6 , solute carrier family 26 member 6
External IDs OMIM: 610068; MGI: 2159728; HomoloGene: 99903; GeneCards: SLC26A6; OMA:SLC26A6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

65010

171429

Ensembl

ENSG00000225697

ENSMUSG00000023259

UniProt

Q9BXS9

Q8CIW6

RefSeq (mRNA)

NM_134420

RefSeq (protein)

NP_599252
NP_001395316

Location (UCSC) Chr 3: 48.63 – 48.64 Mb Chr 9: 108.73 – 108.74 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene. [5] [6] [7] It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum. [8]

Contents

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined. [7]

Associated diseases

Diseases associated with SLC26A6 include sialolithiasis and urolithiasis. [9]

See also

Related Research Articles

<span class="mw-page-title-main">Prestin</span> Protein-coding gene in the species Homo sapiens

Prestin is a protein that is critical to sensitive hearing in mammals. It is encoded by the SLC26A5 gene.

<span class="mw-page-title-main">Pendrin</span> Anion exchange protein

Pendrin is an anion exchange protein that in humans is encoded by the SLC26A4 gene . Pendrin was initially identified as a sodium-independent chloride-iodide exchanger with subsequent studies showing that it also accepts formate and bicarbonate as substrates. Pendrin is similar to the Band 3 transport protein found in red blood cells. Pendrin is the protein which is mutated in Pendred syndrome, which is an autosomal recessive disorder characterized by sensorineural hearing loss, goiter and a partial organification problem detectable by a positive perchlorate test.

<span class="mw-page-title-main">Sulfate transporter</span> Protein-coding gene in the species Homo sapiens

The sulfate transporter is a solute carrier family protein that in humans is encoded by the SLC26A2 gene. SLC26A2 is also called the diastrophic dysplasia sulfate transporter (DTDST), and was first described by Hästbacka et al. in 1994. A defect in sulfate activation described by Superti-Furga in achondrogenesis type 1B was subsequently also found to be caused by genetic variants in the sulfate transporter gene. This sulfate (SO42−) transporter also accepts chloride, hydroxyl ions (OH−), and oxalate as substrates. SLC26A2 is expressed at high levels in developing and mature cartilage, as well as being expressed in lung, placenta, colon, kidney, pancreas and testis.

<span class="mw-page-title-main">Chloride anion exchanger</span> Protein-coding gene in the species Homo sapiens

Chloride anion exchanger, also known as down-regulated in adenoma, is a protein that in humans is encoded by the SLC26A3 gene.

<span class="mw-page-title-main">SLC22A11</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene.

<span class="mw-page-title-main">SLC22A8</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 8, or organic anion transporter 3 (OAT3), is a protein that in humans is encoded by the SLC22A8 gene.

<span class="mw-page-title-main">Solute carrier organic anion transporter family member 1A2</span>

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.

<span class="mw-page-title-main">Sodium-dependent phosphate transport protein 2B</span> Protein-coding gene in the species Homo sapiens

Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene.

<span class="mw-page-title-main">Sodium/myo-inositol cotransporter</span> Protein-coding gene in the species Homo sapiens

Sodium/myo-inositol cotransporter is a protein that in humans is encoded by the SLC5A3 gene.

<span class="mw-page-title-main">Anion exchange transporter</span> Protein-coding gene in the species Homo sapiens

Anion exchange transporter is a protein that in humans is encoded by the SLC26A7 gene.

<span class="mw-page-title-main">Solute carrier organic anion transporter family member 2B1</span> Protein-coding gene in the species Homo sapiens

Solute carrier organic anion transporter family member 2B1 also known as organic anion-transporting polypeptide 2B1 (OATP2B1) is a protein that in humans is encoded by the gene SLCO2B1.

<span class="mw-page-title-main">Solute carrier organic anion transporter family member 4A1</span> Protein-coding gene in the species Homo sapiens

Solute carrier organic anion transporter family member 4A1 is a protein that in humans is encoded by the SLCO4A1 gene.

<span class="mw-page-title-main">Sodium-dependent phosphate transport protein 1</span> Protein-coding gene in the species Homo sapiens

Sodium-dependent phosphate transport protein 1 is a protein that in humans is encoded by the SLC17A1 gene.

<span class="mw-page-title-main">SLC22A7</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 7 is a protein that in humans is encoded by the gene SLC22A7.

<span class="mw-page-title-main">SLC22A9</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 9 is a protein that in humans is encoded by the SLC22A9 gene.

<span class="mw-page-title-main">Solute carrier organic anion transporter family member 3A1</span> Protein-coding gene in the species Homo sapiens

Solute carrier organic anion transporter family member 3A1 is a protein that in humans is encoded by the SLCO3A1 gene.

<span class="mw-page-title-main">SLC26A8</span> Protein-coding gene in the species Homo sapiens

Testis anion transporter 1 is a protein that in humans is encoded by the SLC26A8 gene.

<span class="mw-page-title-main">SLC22A25</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 25 (SLC22A25), also known as organic anion transporter UST6, is a protein that in humans is encoded by the SLC22A25 gene.

<span class="mw-page-title-main">SLC41A1</span> Protein-coding gene in the species Homo sapiens

SLC41A1 is a protein that in humans is encoded by the gene SLC41A1. It is homologous to the prokaryotic Mg++ transfer protein MgtE

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000225697 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023259 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Lohi H, Kujala M, Kerkelä E, Saarialho-Kere U, Kestilä M, Kere J (November 2000). "Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger". Genomics. 70 (1): 102–112. doi:10.1006/geno.2000.6355. PMID   11087667.
  6. ↑ Waldegger S, Moschen I, Ramirez A, Smith RJ, Ayadi H, Lang F, Kubisch C (February 2001). "Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family". Genomics. 72 (1): 43–50. doi:10.1006/geno.2000.6445. PMID   11247665.
  7. 1 2 "Entrez Gene: SLC26A6 solute carrier family 26, member 6".
  8. ↑ Wang Z, Wang T, Petrovic S, Tuo B, Riederer B, Barone S, et al. (April 2005). "Renal and intestinal transport defects in Slc26a6-null mice". American Journal of Physiology. Cell Physiology. 4. 288 (4): C957 –C965. doi:10.1152/ajpcell.00505.2004. PMID   15574486. S2CID   23214608.
  9. ↑ "SLC26A6 Gene - GeneCards | S26A6 Protein | S26A6 Antibody". www.genecards.org. Retrieved 2021-05-06.

Further reading

]* Chernova MN, Jiang L, Friedman DJ, Darman RB, Lohi H, Kere J, et al. (March 2005). "Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity". The Journal of Biological Chemistry. 280 (9): 8564–8580. doi: 10.1074/jbc.M411703200 . PMID   15548529.

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