SLC26A6

Last updated
SLC26A6
Identifiers
Aliases SLC26A6 , solute carrier family 26 member 6
External IDs OMIM: 610068 MGI: 2159728 HomoloGene: 99903 GeneCards: SLC26A6
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_134420

RefSeq (protein)

NP_599252
NP_001395316

Location (UCSC) Chr 3: 48.63 – 48.64 Mb Chr 9: 108.73 – 108.74 Mb
PubMed search [3] [4]
Wikidata
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Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene. [5] [6] [7] It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum. [8]

Contents

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined. [7]

Associated diseases

Diseases associated with SLC26A6 include sialolithiasis and urolithiasis. [9]

See also

Related Research Articles

<span class="mw-page-title-main">Sulfate transporter</span> Protein-coding gene in the species Homo sapiens

The sulfate transporter is a solute carrier family protein that in humans is encoded by the SLC26A2 gene. SLC26A2 is also called the diastrophic dysplasia sulfate transporter (DTDST), and was first described by Hästbacka et al. in 1994. A defect in sulfate activation described by Superti-Furga in achondrogenesis type 1B was subsequently also found to be caused by genetic variants in the sulfate transporter gene. This sulfate (SO42−) transporter also accepts chloride, hydroxyl ions (OH), and oxalate as substrates. SLC26A2 is expressed at high levels in developing and mature cartilage, as well as being expressed in lung, placenta, colon, kidney, pancreas and testis.

<span class="mw-page-title-main">Sodium bicarbonate cotransporter 3</span> Protein-coding gene in the species Homo sapiens

Sodium bicarbonate cotransporter 3 is a protein which in humans is encoded by the SLC4A7 gene.

<span class="mw-page-title-main">SLC22A2</span> Protein-coding gene

Solute carrier family 22 member 2 is a protein that in humans is encoded by the SLC22A2 gene.

<span class="mw-page-title-main">Chloride anion exchanger</span> Protein-coding gene in the species Homo sapiens

Chloride anion exchanger, also known as down-regulated in adenoma, is a protein that in humans is encoded by the SLC26A3 gene.

<span class="mw-page-title-main">Equilibrative nucleoside transporter 2</span> Protein-coding gene in the species Homo sapiens

Equilibrative nucleoside transporter 2 (ENT2) is a protein that in humans is encoded by the SLC29A2 gene.

<span class="mw-page-title-main">Anion exchange protein 3</span> Protein-coding gene in the species Homo sapiens

Anion exchange protein 3 is a membrane transport protein that in humans is encoded by the SLC4A3 gene. AE3 is functionally similar to the Band 3 Cl/HCO3 exchange protein but it is expressed primarily in brain neurons and in the heart. Like AE2 its activity is sensitive to pH. AE3 mutations have been linked to seizures.

<span class="mw-page-title-main">Chloride potassium symporter 4</span> Protein-coding gene in the species Homo sapiens

Potassium-chloride transporter, member 4 is a chloride potassium symporter protein. It is encoded by the gene SLC12A4.

<span class="mw-page-title-main">Solute carrier organic anion transporter family member 1A2</span>

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.

<span class="mw-page-title-main">Anion exchange transporter</span> Protein-coding gene in the species Homo sapiens

Anion exchange transporter is a protein that in humans is encoded by the SLC26A7 gene.

<span class="mw-page-title-main">SLC2A12</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 2, facilitated glucose transporter member 12 is a protein that in humans is encoded by the SLC2A12 gene.

<span class="mw-page-title-main">Urea transporter 2</span> Protein-coding gene in the species Homo sapiens

Urea transporter 2 is a protein that in humans is encoded by the SLC14A2 gene.

<span class="mw-page-title-main">Solute carrier organic anion transporter family member 2B1</span> Protein-coding gene in the species Homo sapiens

Solute carrier organic anion transporter family member 2B1 also known as organic anion-transporting polypeptide 2B1 (OATP2B1) is a protein that in humans is encoded by the gene SLCO2B1.

<span class="mw-page-title-main">Solute carrier organic anion transporter family member 4A1</span> Protein-coding gene in the species Homo sapiens

Solute carrier organic anion transporter family member 4A1 is a protein that in humans is encoded by the SLCO4A1 gene.

<span class="mw-page-title-main">Sodium-dependent phosphate transport protein 1</span> Protein-coding gene in the species Homo sapiens

Sodium-dependent phosphate transport protein 1 is a protein that in humans is encoded by the SLC17A1 gene.

<span class="mw-page-title-main">SLC13A3</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter (NaDC3) is a protein that in humans is encoded by the SLC13A3 gene.

<span class="mw-page-title-main">SLC22A9</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 9 is a protein that in humans is encoded by the SLC22A9 gene.

<span class="mw-page-title-main">Solute carrier organic anion transporter family member 3A1</span> Protein-coding gene in the species Homo sapiens

Solute carrier organic anion transporter family member 3A1 is a protein that in humans is encoded by the SLCO3A1 gene.

<span class="mw-page-title-main">SLC26A8</span> Protein-coding gene in the species Homo sapiens

Testis anion transporter 1 is a protein that in humans is encoded by the SLC26A8 gene.

<span class="mw-page-title-main">Organic anion transporter 1</span> Protein-coding gene in the species Homo sapiens

The organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene. It is a member of the organic anion transporter (OAT) family of proteins. OAT1 is a transmembrane protein that is expressed in the brain, the placenta, the eyes, smooth muscles, and the basolateral membrane of proximal tubular cells of the kidneys. It plays a central role in renal organic anion transport. Along with OAT3, OAT1 mediates the uptake of a wide range of relatively small and hydrophilic organic anions from plasma into the cytoplasm of the proximal tubular cells of the kidneys. From there, these substrates are transported into the lumen of the nephrons of the kidneys for excretion. OAT1 homologs have been identified in rats, mice, rabbits, pigs, flounders, and nematodes.

<span class="mw-page-title-main">SLC22A25</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 22 member 25 (SLC22A25), also known as organic anion transporter UST6, is a protein that in humans is encoded by the SLC22A25 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000225697 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023259 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lohi H; Kujala M; Kerkela E; Saarialho-Kere U; Kestila M; Kere J (Jan 2001). "Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger". Genomics. 70 (1): 102–12. doi:10.1006/geno.2000.6355. PMID   11087667.
  6. Waldegger S; Moschen I; Ramirez A; Smith RJ; Ayadi H; Lang F; Kubisch C (Mar 2001). "Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family". Genomics. 72 (1): 43–50. doi:10.1006/geno.2000.6445. PMID   11247665.
  7. 1 2 "Entrez Gene: SLC26A6 solute carrier family 26, member 6".
  8. Wang, Zhaohui; Tong Wang; Snezana Petrovic; Biguang Tuo; Brigitte Riederer; Sharon Barone; John N. Lorenz; Ursula Seidler; Peter S. Aronson; Manoocher Soleimani (April 2005). "Renal and intestinal transport defects in Slc26a6-null mice". American Journal of Physiology. Cell Physiology. 4. 288 (4): C957–C965. doi:10.1152/ajpcell.00505.2004. PMID   15574486. S2CID   23214608.
  9. "SLC26A6 Gene - GeneCards | S26A6 Protein | S26A6 Antibody". www.genecards.org. Retrieved 2021-05-06.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.