SLC26A6

SLC26A6
Identifiers
Aliases	SLC26A6 , solute carrier family 26 member 6
External IDs	OMIM: 610068; MGI: 2159728; HomoloGene: 99903; GeneCards: SLC26A6; OMA:SLC26A6 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p21.31 Start 48,625,723 bp [1] End 48,635,493 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 F2 Start 108,730,482 bp [2] End 108,742,117 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon Descending thoracic aorta popliteal artery tibial arteries ascending aorta oocyte rectum stromal cell of endometrium left coronary artery body of stomach Top expressed in duodenum jejunum ileum primary oocyte yolk sac pancreas muscle tissue skeletal muscle tissue quadriceps femoris muscle secondary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function PDZ domain binding formate transmembrane transporter activity chloride transmembrane transporter activity anion transmembrane transporter activity sulfate transmembrane transporter activity secondary active sulfate transmembrane transporter activity bicarbonate transmembrane transporter activity formate efflux transmembrane transporter activity oxalate transmembrane transporter activity protein binding efflux transmembrane transporter activity antiporter activity chloride channel activity inorganic anion exchanger activity Cellular component integral component of membrane membrane intracellular membrane-bounded organelle vesicle membrane plasma membrane integral component of plasma membrane chloride channel complex brush border membrane basolateral plasma membrane apical plasma membrane endoplasmic reticulum sperm midpiece cytoplasmic vesicle membrane cytoplasmic vesicle intracellular anatomical structure vesicle Biological process oxalic acid secretion mannitol transport oxalate transport formate transport intracellular pH elevation sulfate transport epithelial fluid transport angiotensin-activated signaling pathway regulation of membrane potential regulation of intracellular pH cellular response to fructose stimulus ion transport transepithelial chloride transport protein kinase C signaling anion transport transepithelial transport cellular response to interferon-gamma sperm capacitation intestinal absorption chloride transport positive regulation of dipeptide transmembrane transport cellular response to cAMP anion transmembrane transport sulfate transmembrane transport bicarbonate transport transmembrane transport chloride transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 65010 171429 Ensembl ENSG00000225697 ENSMUSG00000023259 UniProt Q9BXS9 Q8CIW6 RefSeq (mRNA) NM_134426 NM_001040454 NM_001281732 NM_001281733 NM_022911 NM_134263 NM_134420 RefSeq (protein) NP_001035544 NP_001268661 NP_001268662 NP_075062 NP_599025 NP_602298 NP_001035544.1 NP_599252 NP_001395316 Location (UCSC) Chr 3: 48.63 – 48.64 Mb Chr 9: 108.73 – 108.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene. ^{[5] [6] [7]} It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum. ^[8]

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined. ^[7]

Associated diseases

Diseases associated with SLC26A6 include sialolithiasis and urolithiasis. ^[9]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000225697 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023259 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lohi H, Kujala M, Kerkelä E, Saarialho-Kere U, Kestilä M, Kere J (November 2000). "Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger". Genomics. 70 (1): 102–112. doi:10.1006/geno.2000.6355. PMID   11087667.
6. Waldegger S, Moschen I, Ramirez A, Smith RJ, Ayadi H, Lang F, Kubisch C (February 2001). "Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family". Genomics. 72 (1): 43–50. doi:10.1006/geno.2000.6445. PMID   11247665.
7. "Entrez Gene: SLC26A6 solute carrier family 26, member 6".
8. Wang Z, Wang T, Petrovic S, Tuo B, Riederer B, Barone S, et al. (April 2005). "Renal and intestinal transport defects in Slc26a6-null mice". American Journal of Physiology. Cell Physiology. 4. 288 (4): C957 –C965. doi:10.1152/ajpcell.00505.2004. PMID   15574486. S2CID   23214608.
9. "SLC26A6 Gene - GeneCards | S26A6 Protein | S26A6 Antibody". www.genecards.org. Retrieved 2021-05-06.

Further reading

• Markovich D (October 2001). "Physiological roles and regulation of mammalian sulfate transporters". Physiological Reviews. 81 (4): 1499–1533. doi:10.1152/physrev.2001.81.4.1499. PMID   11581495. S2CID   30942862.
• Ignatovich O, Tomlinson IM, Popov AV, Brüggemann M, Winter G (November 1999). "Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire". Journal of Molecular Biology. 294 (2): 457–465. doi:10.1006/jmbi.1999.3243. PMID   10610771.
• Xie Q, Welch R, Mercado A, Romero MF, Mount DB (October 2002). "Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1". American Journal of Physiology. Renal Physiology. 283 (4): F826 –F838. doi:10.1152/ajprenal.00079.2002. PMID   12217875.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.

]* Chernova MN, Jiang L, Friedman DJ, Darman RB, Lohi H, Kere J, et al. (March 2005). "Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity". The Journal of Biological Chemistry. 280 (9): 8564–8580. doi: 10.1074/jbc.M411703200 . PMID   15548529.

• Kujala M, Tienari J, Lohi H, Elomaa O, Sariola H, Lehtonen E, Kere J (2006). "SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney". Nephron. Experimental Nephrology. 101 (2): e50 –e58. doi:10.1159/000086345. PMID   15956810. S2CID   26671784.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Shcheynikov N, Wang Y, Park M, Ko SB, Dorwart M, Naruse S, et al. (May 2006). "Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6". The Journal of General Physiology. 127 (5): 511–524. doi:10.1085/jgp.200509392. PMC   2151520 . PMID   16606687.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Alper SL, Stewart AK, Chernova MN, et al. (2007). "Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptides". Epithelial Anion Transport in Health and Disease: The Role of the SLC26 Transporters Family. Novartis Foundation Symposia. Vol. 273. pp. 107–19, discussion 119–25, 261–4. doi:10.1002/0470029579.ch8. ISBN   9780470016244. PMID   17120764.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.