SLC41A1

SLC41A1
Identifiers
Aliases	SLC41A1 , MgtE, solute carrier family 41 member 1, NPHPL2
External IDs	OMIM: 610801 MGI: 2444823 HomoloGene: 14871 GeneCards: SLC41A1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	205,813,748 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	131,776,603 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; tibialis anterior muscle; ; body of tongue; ; body of pancreas; ; vena cava; ; deltoid muscle; ; quadriceps femoris muscle; ; left lobe of thyroid gland; ; gastrocnemius muscle; ; vastus lateralis muscle;
	Top expressed in
	extraocular muscle; ; digastric muscle; ; saccule; ; stria vascularis; ; optic nerve; ; soleus muscle; ; thoracic diaphragm; ; sternocleidomastoid muscle; ; ciliary body; ; plantaris muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	cation transmembrane transporter activity ; magnesium ion transmembrane transporter activity ; magnesium:sodium antiporter activity ; transmembrane transporter activity ;
Cellular component	integral component of membrane ; membrane ; plasma membrane ; basolateral plasma membrane ; protein-containing complex ;
Biological process	cation transport ; ion transport ; sodium ion transmembrane transport ; magnesium ion transmembrane transport ; cellular magnesium ion homeostasis ; magnesium ion transport ; cellular response to magnesium ion ;
	Sources:Amigo / QuickGO
Orthologs
	254428
	98396
	ENSG00000133065
	ENSMUSG00000013275
	Q8IVJ1
	Q8BJA2
	NM_173854
	NM_173865
	NP_776253
	NP_776290
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

SLC41A1 is a protein that in humans is encoded by the gene SLC41A1.^[5] It is homologous to the prokaryotic Mg++ transfer protein MgtE ^[6]

Mutations in this gene have been associated to Nephronophthisis-like phenotypes.^[7]

Related Research Articles

Zinc transporter ZIP4 is a transmembrane protein which in humans is encoded by the SLC39A4 gene. It is associated with acrodermatitis enteropathica.

b(0,+)-type amino acid transporter 1, also known as b(0,+)AT1, is a protein which in humans is encoded by the SLC7A9 gene.

Sialin, also known as H(+)/nitrate cotransporter and H(+)/sialic acid cotransporter, is a protein which in humans is encoded by the SLC17A5 gene.

Sodium- and chloride-dependent creatine transporter 1 is a protein that in humans is encoded by the SLC6A8 gene.

Urea transporter 1 is a protein that in humans is encoded by the SLC14A1 gene.

Sodium bicarbonate transporter-like protein 11 is a protein that in humans is encoded by the SLC4A11 gene.

Sodium- and chloride-dependent glycine transporter 2, also known as glycine transporter 2 (GlyT2), is a protein that in humans is encoded by the SLC6A5 gene.

Testis anion transporter 1 is a protein that in humans is encoded by the SLC26A8 gene.

Solute carrier family 6, member 18 also known as SLC6A18 is a protein which in humans is encoded by the SLC6A18 gene.

Solute carrier family 6, member 20 also known as SLC6A20 is a protein which in humans is encoded by the SLC6A20 gene.

Proton-coupled amino acid transporter 2 is a protein which in humans is encoded by the SLC36A2 gene.

Solute carrier family 41, member 3 is a protein that in humans is encoded by the SLC41A3 gene.

Acetyl-coenzyme A transporter 1 also known as solute carrier family 33 member 1 (SLC33A1) is a protein that in humans is encoded by the SLC33A1 gene.

Calcium-binding mitochondrial carrier protein SCaMC-1 is a protein that in humans is encoded by the SLC25A24 gene.

Solute carrier family 7, member 14 is a protein that in humans is encoded by the SLC7A14 gene.

Sodium-dependent phosphate transport protein 2A, also known as Na⁺-P_i cotransporter 2a (NaPi-2a), is a protein in humans that is encoded by the SLC34A1 gene. This gene encodes a member of the type II sodium-phosphate cotransporter family.

Solute carrier family 17 member 9 is a protein that in humans is encoded by the SLC17A9 gene.

Glucose-6-phosphate exchanger SLC37A1 is a protein that in humans is encoded by the SLC37A1 gene. SLC37A1 locates to the membrane of the endoplasmic reticulum (ER), and is a glucose 6-phosphate:inorganic phosphate antiporter, transporting glucose 6-phosphate from the cytoplasm into the lumen of the ER, while transporting phosphate in the opposite direction.

SLC45A1 is a member of the SLC45 family of solute carriers. Analysis of the protein function in a recombinant yeast expression assay show that it can: (i) transport a disaccharide, such as glucose and sucrose (ii) perform secondary active transport in a proton-dependent manner.

Nipa‐Like Domain‐Containing 4, also known as NIPAL4 or Ichthyin, is a gene that is predicted to code for a transmembrane protein with nine transmembrane domains. NIPAL4 codes for the protein magnesium transporter NIPA4, which acts as a Mg²⁺
transporter.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000133065 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000013275 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wabakken T, Rian E, Kveine M, Aasheim HC (July 2003). "The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters". Biochemical and Biophysical Research Communications. 306 (3): 718–24. doi:10.1016/S0006-291X(03)01030-1. PMID 12810078.
↑ Goytain A, Quamme GA (May 2005). "Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters". Physiological Genomics. 21 (3): 337–42. doi:10.1152/physiolgenomics.00261.2004. PMID 15713785.
↑ Hurd TW, Otto EA, Mishima E, Gee HY, Inoue H, Inazu M, et al. (May 2013). "Mutation of the Mg2+ transporter SLC41A1 results in a nephronophthisis-like phenotype". Journal of the American Society of Nephrology. 24 (6): 967–77. doi:10.1681/ASN.2012101034. PMC 3665398 . PMID 23661805.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000133065 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000013275 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12810078-5] Wabakken T, Rian E, Kveine M, Aasheim HC (July 2003). "The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters". Biochemical and Biophysical Research Communications. 306 (3): 718–24. doi:10.1016/S0006-291X(03)01030-1. PMID 12810078.

[pmid15713785-6] Goytain A, Quamme GA (May 2005). "Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters". Physiological Genomics. 21 (3): 337–42. doi:10.1152/physiolgenomics.00261.2004. PMID 15713785.

[pmid23661805-7] Hurd TW, Otto EA, Mishima E, Gee HY, Inoue H, Inazu M, et al. (May 2013). "Mutation of the Mg2+ transporter SLC41A1 results in a nephronophthisis-like phenotype". Journal of the American Society of Nephrology. 24 (6): 967–77. doi:10.1681/ASN.2012101034. PMC 3665398 . PMID 23661805.

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