SLC23A1

SLC23A1
Identifiers
Aliases	SLC23A1 , SLC23A2, SVCT1, YSPL3, solute carrier family 23 member 1
External IDs	OMIM: 603790 MGI: 1341903 HomoloGene: 40769 GeneCards: SLC23A1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	139,384,553 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	35,627,244 bp
Gene ontology
Molecular function	• nucleobase transmembrane transporter activity ; • transporter activity ; • dehydroascorbic acid transmembrane transporter activity ; • sodium ion transmembrane transporter activity ; • GO:0001948 protein binding ; • L-ascorbate:sodium symporter activity ; • symporter activity ; • L-ascorbic acid transmembrane transporter activity ; • GO:0022891 transmembrane transporter activity ;
Cellular component	• cytoplasm ; • integral component of membrane ; • membrane ; • plasma membrane ; • integral component of plasma membrane ; • basal plasma membrane ; • apical plasma membrane ; • intracellular organelle ; • extracellular exosome ; • brush border ;
Biological process	• lung development ; • sodium ion transport ; • transepithelial L-ascorbic acid transport ; • ion transport ; • L-ascorbic acid transmembrane transport ; • brain development ; • nucleobase transport ; • transmembrane transport ; • nucleobase-containing compound metabolic process ; • response to toxic substance ; • dehydroascorbic acid transport ; • L-ascorbic acid metabolic process ; • sodium ion transmembrane transport ; • transport ;
	Sources:Amigo / QuickGO
Orthologs
	9963
	20522
	ENSG00000170482
	ENSMUSG00000024354
	Q9UHI7
	Q9Z2J0
	NM_005847 ; NM_152685
	NM_011397
	NP_005838 ; NP_689898
	NP_035527
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 07, 2021

Solute carrier family 23 member 1 is a protein that in humans is encoded by the SLC23A1 gene.^[5]^[6]^[7]

Function

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2.^[7]

Related Research Articles

SLC22A5 is a membrane transport protein associated with primary carnitine deficiency. This protein is involved in the active cellular uptake of carnitine. It acts a symporter, moving sodium ions and other organic cations across the membrane along with carnitine. Such polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for the elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Mutations in the SLC22A5 gene cause systemic primary carnitine deficiency, which can lead to heart failure.

Natural resistance-associated macrophage protein 2, also known as divalent metal transporter 1 (DMT1) and divalent cation transporter 1 (DCT1), is a protein that in humans is encoded by the SLC11A2 gene. DMT1 represents a large family of orthologous metal ion transporter proteins that are highly conserved from bacteria to humans.

Sodium/glucose cotransporter 1 (SGLT1) also known as solute carrier family 5 member 1 is a protein in humans that is encoded by the SLC5A1 gene which encodes the production of the SGLT1 protein to line the absorptive cells in the small intestine and the epithelial cells of the kidney tubules of the nephron for the purpose of glucose uptake into cells. Through the use of the sodium glucose cotransporter 1 protein, cells are able to obtain glucose which is further utilized to make and store energy for the cell.

Folate transporter 1 is a protein which in humans is encoded by the SLC19A1 gene.

Peptide transporter 1 also known as solute carrier family 15 member 1 (SLC15A1) is a protein that in humans is encoded by SLC15A1 gene. PepT 1 is a solute carrier for oligopeptides. It functions in renal oligopeptide reabsorption and in the intestines in a proton dependent way, hence acting like a cotransporter.

Sodium bicarbonate cotransporter 3 is a protein which in humans is encoded by the SLC4A7 gene.

Solute carrier family 22, member 4, also known as SLC22A4, is a human gene; the encoded protein is known as the ergothioneine transporter.

Solute carrier family 23 member 2 is a protein that in humans is encoded by the SLC23A2 gene.

Neutral amino acid transporter B(0) is a protein that in humans is encoded by the SLC1A5 gene.

Concentrative nucleoside transporter 2 (CNT2) is a protein that in humans is encoded by the SLC28A2 gene.

Sodium- and chloride-dependent taurine transporter is a protein that in humans is encoded by the SLC6A6 gene.

Aquaporin-9 is a protein that in humans is encoded by the AQP9 gene.

Sodium- and chloride-dependent glycine transporter 2, also known as glycine transporter 2 (GlyT2), is a protein that in humans is encoded by the SLC6A5 gene.

Sodium-dependent multivitamin transporter is a protein that in humans is encoded by the SLC5A6 gene.

Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene.

Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (SLC6A14) is a protein that in humans is encoded by the SLC6A14 gene.

Sodium-dependent phosphate transport protein 1 is a protein that in humans is encoded by the SLC17A1 gene.

Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter (NaDC3) is a protein that in humans is encoded by the SLC13A3 gene.

Sodium-dependent neutral amino acid transporter B(0)AT2 is a protein that in humans is encoded by the SLC6A15 gene.

Solute carrier family 13 (sodium-dependent citrate transporter), member 5 also known as the Na⁺/citrate cotransporter or mIndy is a protein that in humans is encoded by the SLC13A5 gene. It is the mammalian homolog of the fly Indy (gene).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170482 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024354 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Faaland CA, Race JE, Ricken G, Warner FJ, Williams WJ, Holtzman EJ (November 1998). "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1442 (2–3): 353–60. doi:10.1016/S0167-4781(98)00151-1. PMID 9804989.
↑ Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA (May 1999). "A family of mammalian Na+-dependent L-ascorbic acid transporters". Nature. 399 (6731): 70–5. Bibcode:1999Natur.399...70T. doi:10.1038/19986. PMID 10331392. S2CID 4425479.
1 2 "Entrez Gene: SLC23A1 solute carrier family 23 (nucleobase transporters), member 1".

Liang WJ, Johnson D, Jarvis SM (2001). "Vitamin C transport systems of mammalian cells". Molecular Membrane Biology. 18 (1): 87–95. doi:10.1080/09687680110033774. PMID 11396616. S2CID 22478598.
Hogue DL, Ling V (July 1999). "A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals". Genomics. 59 (1): 18–23. doi:10.1006/geno.1999.5847. PMID 10395795.
Rajan DP, Huang W, Dutta B, Devoe LD, Leibach FH, Ganapathy V, Prasad PD (September 1999). "Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function". Biochemical and Biophysical Research Communications. 262 (3): 762–8. doi:10.1006/bbrc.1999.1272. PMID 10471399.
Wang H, Dutta B, Huang W, Devoe LD, Leibach FH, Ganapathy V, Prasad PD (November 1999). "Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1461 (1): 1–9. doi: 10.1016/S0005-2736(99)00182-0 . PMID 10556483.
Daruwala R, Song J, Koh WS, Rumsey SC, Levine M (November 1999). "Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2". FEBS Letters. 460 (3): 480–4. doi: 10.1016/S0014-5793(99)01393-9 . PMID 10556521. S2CID 37936975.
Wang Y, Mackenzie B, Tsukaguchi H, Weremowicz S, Morton CC, Hediger MA (January 2000). "Human vitamin C (L-ascorbic acid) transporter SVCT1". Biochemical and Biophysical Research Communications. 267 (2): 488–94. doi:10.1006/bbrc.1999.1929. PMID 10631088.
Erichsen HC, Eck P, Levine M, Chanock S (October 2001). "Characterization of the genomic structure of the human vitamin C transporter SVCT1 (SLC23A2)". The Journal of Nutrition. 131 (10): 2623–7. doi: 10.1093/jn/131.10.2623 . PMID 11584081.
Hediger MA (May 2002). "New view at C". Nature Medicine. 8 (5): 445–6. doi:10.1038/nm0502-445. PMID 11984580. S2CID 787845.
Maulén NP, Henríquez EA, Kempe S, Cárcamo JG, Schmid-Kotsas A, Bachem M, Grünert A, Bustamante ME, Nualart F, Vera JC (March 2003). "Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells". The Journal of Biological Chemistry. 278 (11): 9035–41. doi: 10.1074/jbc.M205119200 . PMID 12381735.
Liang WJ, Johnson D, Ma LS, Jarvis SM, Wei-Jun L (December 2002). "Regulation of the human vitamin C transporters expressed in COS-1 cells by protein kinase C [corrected]". American Journal of Physiology. Cell Physiology. 283 (6): C1696-704. doi:10.1152/ajpcell.00461.2001. PMID 12388072.
Boyer JC, Campbell CE, Sigurdson WJ, Kuo SM (August 2005). "Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells". Biochemical and Biophysical Research Communications. 334 (1): 150–6. doi:10.1016/j.bbrc.2005.06.069. PMID 15993839.
Erichsen HC, Engel SA, Eck PK, Welch R, Yeager M, Levine M, Siega-Riz AM, Olshan AF, Chanock SJ (February 2006). "Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery". American Journal of Epidemiology. 163 (3): 245–54. doi: 10.1093/aje/kwj035 . PMID 16357110.
Kang JS, Kim HN, Jung DJ, Kim JE, Mun GH, Kim YS, Cho D, Shin DH, Hwang YI, Lee WJ (March 2007). "Regulation of UVB-induced IL-8 and MCP-1 production in skin keratinocytes by increasing vitamin C uptake via the redistribution of SVCT-1 from the cytosol to the membrane". The Journal of Investigative Dermatology. 127 (3): 698–706. doi: 10.1038/sj.jid.5700572 . PMID 17008880.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000170482 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024354 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9804989-5] Faaland CA, Race JE, Ricken G, Warner FJ, Williams WJ, Holtzman EJ (November 1998). "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1442 (2–3): 353–60. doi:10.1016/S0167-4781(98)00151-1. PMID 9804989.

[pmid10331392-6] Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA (May 1999). "A family of mammalian Na+-dependent L-ascorbic acid transporters". Nature. 399 (6731): 70–5. Bibcode:1999Natur.399...70T. doi:10.1038/19986. PMID 10331392. S2CID 4425479.

[entrez-7] 1 2 "Entrez Gene: SLC23A1 solute carrier family 23 (nucleobase transporters), member 1".

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SLC23A1

Contents

Function

See also

Related Research Articles

References

Further reading