SLC23A1

Last updated
SLC23A1
Identifiers
Aliases SLC23A1 , SLC23A2, SVCT1, YSPL3, solute carrier family 23 member 1
External IDs OMIM: 603790 MGI: 1341903 HomoloGene: 40769 GeneCards: SLC23A1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005847
NM_152685

NM_011397

RefSeq (protein)

NP_005838
NP_689898

NP_035527

Location (UCSC) Chr 5: 139.37 – 139.38 Mb Chr 18: 35.61 – 35.63 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 23 member 1 is a protein that in humans is encoded by the SLC23A1 gene. [5] [6] [7]

Contents

Function

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. [7]

See also

Related Research Articles

SLC22A5

SLC22A5 is a membrane transport protein associated with primary carnitine deficiency. This protein is involved in the active cellular uptake of carnitine. It acts a symporter, moving sodium ions and other organic cations across the membrane along with carnitine. Such polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for the elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Mutations in the SLC22A5 gene cause systemic primary carnitine deficiency, which can lead to heart failure.

Natural resistance-associated macrophage protein 2

Natural resistance-associated macrophage protein 2, also known as divalent metal transporter 1 (DMT1) and divalent cation transporter 1 (DCT1), is a protein that in humans is encoded by the SLC11A2 gene. DMT1 represents a large family of orthologous metal ion transporter proteins that are highly conserved from bacteria to humans.

Sodium/glucose cotransporter 1

Sodium/glucose cotransporter 1 (SGLT1) also known as solute carrier family 5 member 1 is a protein in humans that is encoded by the SLC5A1 gene which encodes the production of the SGLT1 protein to line the absorptive cells in the small intestine and the epithelial cells of the kidney tubules of the nephron for the purpose of glucose uptake into cells. Through the use of the sodium glucose cotransporter 1 protein, cells are able to obtain glucose which is further utilized to make and store energy for the cell.

Folate transporter 1

Folate transporter 1 is a protein which in humans is encoded by the SLC19A1 gene.

Peptide transporter 1

Peptide transporter 1 also known as solute carrier family 15 member 1 (SLC15A1) is a protein that in humans is encoded by SLC15A1 gene. PepT 1 is a solute carrier for oligopeptides. It functions in renal oligopeptide reabsorption and in the intestines in a proton dependent way, hence acting like a cotransporter.

Sodium bicarbonate cotransporter 3

Sodium bicarbonate cotransporter 3 is a protein which in humans is encoded by the SLC4A7 gene.

SLC22A4

Solute carrier family 22, member 4, also known as SLC22A4, is a human gene; the encoded protein is known as the ergothioneine transporter.

SLC23A2

Solute carrier family 23 member 2 is a protein that in humans is encoded by the SLC23A2 gene.

Neutral amino acid transporter B(0)

Neutral amino acid transporter B(0) is a protein that in humans is encoded by the SLC1A5 gene.

Concentrative nucleoside transporter 2

Concentrative nucleoside transporter 2 (CNT2) is a protein that in humans is encoded by the SLC28A2 gene.

Sodium- and chloride-dependent taurine transporter

Sodium- and chloride-dependent taurine transporter is a protein that in humans is encoded by the SLC6A6 gene.

AQP9

Aquaporin-9 is a protein that in humans is encoded by the AQP9 gene.

Sodium- and chloride-dependent glycine transporter 2

Sodium- and chloride-dependent glycine transporter 2, also known as glycine transporter 2 (GlyT2), is a protein that in humans is encoded by the SLC6A5 gene.

Sodium-dependent multivitamin transporter

Sodium-dependent multivitamin transporter is a protein that in humans is encoded by the SLC5A6 gene.

Sodium-dependent phosphate transport protein 2B

Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene.

SLC6A14

Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (SLC6A14) is a protein that in humans is encoded by the SLC6A14 gene.

Sodium-dependent phosphate transport protein 1

Sodium-dependent phosphate transport protein 1 is a protein that in humans is encoded by the SLC17A1 gene.

SLC13A3

Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter (NaDC3) is a protein that in humans is encoded by the SLC13A3 gene.

Sodium-dependent neutral amino acid transporter B(0)AT2

Sodium-dependent neutral amino acid transporter B(0)AT2 is a protein that in humans is encoded by the SLC6A15 gene.

SLC13A5

Solute carrier family 13 (sodium-dependent citrate transporter), member 5 also known as the Na+/citrate cotransporter or mIndy is a protein that in humans is encoded by the SLC13A5 gene. It is the mammalian homolog of the fly Indy (gene).

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000170482 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024354 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Faaland CA, Race JE, Ricken G, Warner FJ, Williams WJ, Holtzman EJ (November 1998). "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1442 (2–3): 353–60. doi:10.1016/S0167-4781(98)00151-1. PMID   9804989.
  6. Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA (May 1999). "A family of mammalian Na+-dependent L-ascorbic acid transporters". Nature. 399 (6731): 70–5. Bibcode:1999Natur.399...70T. doi:10.1038/19986. PMID   10331392. S2CID   4425479.
  7. 1 2 "Entrez Gene: SLC23A1 solute carrier family 23 (nucleobase transporters), member 1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.