SLC12A7

SLC12A7
Identifiers
Aliases	SLC12A7 , KCC4, solute carrier family 12 member 7
External IDs	OMIM: 604879; MGI: 1342283; HomoloGene: 21312; GeneCards: SLC12A7; OMA:SLC12A7 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5p15.33 Start 1,050,384 bp [1] End 1,112,063 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13 C1|13 40.15 cM Start 73,881,213 bp [2] End 73,964,873 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart left ventricle right lobe of liver gallbladder duodenum right auricle of heart human kidney body of stomach spleen granulocyte Top expressed in vestibular membrane of cochlear duct right ventricle myocardium of ventricle transitional epithelium of urinary bladder cardiac muscle tissue of left ventricle lumbar spinal ganglion epithelium of stomach left lobe of liver interventricular septum right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity cation:chloride symporter activity symporter activity protein kinase binding potassium:chloride symporter activity Cellular component integral component of membrane integral component of plasma membrane membrane plasma membrane protein-containing complex Biological process potassium ion transport cell volume homeostasis chloride transmembrane transport chemical synaptic transmission potassium ion transmembrane transport transmembrane transport ion transport chloride ion homeostasis potassium ion homeostasis potassium ion import across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10723 20499 Ensembl ENSG00000276482 ENSG00000113504 ENSMUSG00000017756 UniProt Q9Y666 Q9WVL3 RefSeq (mRNA) NM_006598 NM_011390 NM_001360694 RefSeq (protein) NP_006589 NP_035520 NP_001347623 Location (UCSC) Chr 5: 1.05 – 1.11 Mb Chr 13: 73.88 – 73.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 12 member 7 is a protein that in humans is encoded by the SLC12A7 gene. ^{[5] [6]}

See also

• Solute carrier family
• cotransporter

References

1. ENSG00000113504 GRCh38: Ensembl release 89: ENSG00000276482, ENSG00000113504 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000017756 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mount DB, Mercado A, Song L, Xu J, George AL, Delpire E, Gamba G (June 1999). "Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family". The Journal of Biological Chemistry. 274 (23): 16355–62. doi: 10.1074/jbc.274.23.16355 . PMID   10347194.
6. "Entrez Gene: SLC12A7 solute carrier family 12 (potassium/chloride transporters), member 7".

Further reading

• Mercado A, Song L, Vazquez N, Mount DB, Gamba G (September 2000). "Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4". The Journal of Biological Chemistry. 275 (39): 30326–34. doi: 10.1074/jbc.M003112200 . PMID   10913127.
• Hattori A, Okumura K, Nagase T, Kikuno R, Hirosawa M, Ohara O (December 2000). "Characterization of long cDNA clones from human adult spleen". DNA Research. 7 (6): 357–66. doi: 10.1093/dnares/7.6.357 . PMID   11214971.
• Boettger T, Hübner CA, Maier H, Rust MB, Beck FX, Jentsch TJ (April 2002). "Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4". Nature. 416 (6883): 874–8. Bibcode:2002Natur.416..874B. doi:10.1038/416874a. PMID   11976689. S2CID   4389928.
• Bräuer M, Frei E, Claes L, Grissmer S, Jäger H (July 2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts". American Journal of Physiology. Cell Physiology. 285 (1): C22-30. doi:10.1152/ajpcell.00289.2002. PMID   12637262.
• Karadsheh MF, Byun N, Mount DB, Delpire E (2004). "Localization of the KCC4 potassium-chloride cotransporter in the nervous system". Neuroscience. 123 (2): 381–91. doi:10.1016/j.neuroscience.2003.10.004. PMID   14698746. S2CID   41970238.
• Shen MR, Lin AC, Hsu YM, Chang TJ, Tang MJ, Alper SL, Ellory JC, Chou CY (September 2004). "Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells". The Journal of Biological Chemistry. 279 (38): 40017–25. doi: 10.1074/jbc.M406706200 . PMID   15262997.
• Hsu YM, Chou CY, Chen HH, Lee WY, Chen YF, Lin PW, Alper SL, Ellory JC, Shen MR (March 2007). "IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness". Journal of Cellular Physiology. 210 (3): 626–36. doi: 10.1002/jcp.20859 . PMID   17133354. S2CID   21615465.