SLC26A8

Last updated
SLC26A8
Identifiers
Aliases SLC26A8 , SPGF3, TAT1, solute carrier family 26 member 8
External IDs OMIM: 608480 MGI: 2385046 HomoloGene: 27095 GeneCards: SLC26A8
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001193476
NM_052961
NM_138718

NM_001290320
NM_146076

RefSeq (protein)

NP_001180405
NP_443193
NP_619732

NP_001277249

Location (UCSC) Chr 6: 35.94 – 36.02 Mb Chr 17: 28.86 – 28.91 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Testis anion transporter 1 is a protein that in humans is encoded by the SLC26A8 gene. [5] [6] [7]

Contents

Function

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene is expressed primarily in spermatocytes. Two transcript variants encoding different isoforms have been found. [7]

Interactions

SLC26A8 has been shown to interact with RACGAP1. [8]

Related Research Articles

<span class="mw-page-title-main">Neutral and basic amino acid transport protein rBAT</span>

Neutral and basic amino acid transport protein rBAT is a protein that in humans is encoded by the SLC3A1 gene.

<span class="mw-page-title-main">Sulfate transporter</span>

The sulfate transporter is a solute carrier family protein that in humans is encoded by the SLC26A2 gene. SLC26A2 is also called the diastrophic dysplasia sulfate transporter (DTDST), and was first described by Hästbacka et al. in 1994. A defect in sulfate activation described by Superti-Furga in achondrogenesis type 1B was subsequently also found to be caused by genetic variants in the sulfate transporter gene. This sulfate (SO42−) transporter also accepts chloride, hydroxyl ions (OH), and oxalate as substrates. SLC26A2 is expressed at high levels in developing and mature cartilage, as well as being expressed in lung, placenta, colon, kidney, pancreas and testis.

<span class="mw-page-title-main">RACGAP1</span>

Rac GTPase-activating protein 1 is an enzyme that in humans is encoded by the RACGAP1 gene.

<span class="mw-page-title-main">Solute carrier organic anion transporter family member 1B1</span>

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene. Pharmacogenomic research indicates that genetic variations in this gene are associated with response to simvastatin. Clinical guidelines exist that can guide dosing of simvastatin based on SLCO1B1 gene variant using genotyping or whole exome sequencing.

<span class="mw-page-title-main">Chloride anion exchanger</span> Protein-coding gene in the species Homo sapiens

Chloride anion exchanger, also known as down-regulated in adenoma, is a protein that in humans is encoded by the SLC26A3 gene.

<span class="mw-page-title-main">High affinity copper uptake protein 1</span> Protein-coding gene in the species Homo sapiens

High affinity copper uptake protein 1 (CTR1) is a protein that in humans is encoded by the SLC31A1 gene.

<span class="mw-page-title-main">Equilibrative nucleoside transporter 2</span>

Equilibrative nucleoside transporter 2 (ENT2) is a protein that in humans is encoded by the SLC29A2 gene.

<span class="mw-page-title-main">Urea transporter 1</span>

Urea transporter 1 is a protein that in humans is encoded by the SLC14A1 gene.

<span class="mw-page-title-main">SLC26A6</span>

Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene. It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.

<span class="mw-page-title-main">Rnd2</span> Protein-coding gene in the species Homo sapiens

Rnd2 is a small signaling G protein, and is a member of the Rnd subgroup of the Rho family of GTPases. It is encoded by the gene RND2.

<span class="mw-page-title-main">CMP-sialic acid transporter</span>

CMP-sialic acid transporter is a protein that in humans is encoded by the SLC35A1 gene.

<span class="mw-page-title-main">Large neutral amino acids transporter small subunit 2</span>

Large neutral amino acids transporter small subunit 2 is a protein that in humans is encoded by the SLC7A8 gene.

<span class="mw-page-title-main">Zinc transporter ZIP1</span>

Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.

<span class="mw-page-title-main">Solute carrier organic anion transporter family member 1B3</span>

Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene.

<span class="mw-page-title-main">Solute carrier organic anion transporter family member 1A2</span>

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.

<span class="mw-page-title-main">Anion exchange transporter</span> Protein-coding gene in the species Homo sapiens

Anion exchange transporter is a protein that in humans is encoded by the SLC26A7 gene.

<span class="mw-page-title-main">Zinc transporter ZIP2</span>

Zinc transporter ZIP2 is a protein that in humans is encoded by the SLC39A2 gene.

<span class="mw-page-title-main">Solute carrier organic anion transporter family member 4A1</span>

Solute carrier organic anion transporter family member 4A1 is a protein that in humans is encoded by the SLCO4A1 gene.

<span class="mw-page-title-main">SLC22A9</span>

Solute carrier family 22 member 9 is a protein that in humans is encoded by the SLC22A9 gene.

<span class="mw-page-title-main">Monocarboxylate transporter 10</span>

Monocarboxylate transporter 10, also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 (TAT1) and solute carrier family 16 member 10 (SLC16A10), is a protein that in humans is encoded by the SLC16A10 gene. SLC16A10 is a member of the solute carrier family.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000112053 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036196 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J (Apr 2002). "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9". J. Biol. Chem. 277 (16): 14246–54. doi: 10.1074/jbc.M111802200 . PMID   11834742.
  6. Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP (Feb 2002). "Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney". Genomics. 79 (2): 249–56. doi:10.1006/geno.2002.6689. PMID   11829495.
  7. 1 2 "Entrez Gene: SLC26A8 solute carrier family 26, member 8".
  8. Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G (Jun 2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. 276 (23): 20309–15. doi: 10.1074/jbc.M011740200 . PMID   11278976.

Further reading