SLC13A3

SLC13A3
Identifiers
Aliases	SLC13A3 , NADC3, SDCT2, solute carrier family 13 member 3, ARLIAK
External IDs	OMIM: 606411; MGI: 2149635; HomoloGene: 11266; GeneCards: SLC13A3; OMA:SLC13A3 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.12 Start 46,557,823 bp [1] End 46,684,467 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H3 Start 165,246,948 bp [2] End 165,315,150 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney tubule metanephric glomerulus oocyte secondary oocyte olfactory bulb human kidney C1 segment corpus callosum right lobe of liver placenta Top expressed in median eminence retinal pigment epithelium human kidney right kidney Rostral migratory stream proximal tubule pontine nuclei mammillary body olfactory tubercle arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity symporter activity succinate transmembrane transporter activity sodium:dicarboxylate symporter activity citrate transmembrane transporter activity high-affinity sodium:dicarboxylate symporter activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane extracellular exosome Biological process dicarboxylic acid transport sodium ion transport ion transport succinate transmembrane transport citrate transport transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64849 114644 Ensembl ENSG00000158296 ENSMUSG00000018459 UniProt Q8WWT9 Q91Y63 RefSeq (mRNA) NM_022829 NM_001011554 NM_001193339 NM_001193340 NM_001193342 NM_054055 RefSeq (protein) NP_001011554 NP_001180268 NP_001180269 NP_001180271 NP_073740 NP_473396 Location (UCSC) Chr 20: 46.56 – 46.68 Mb Chr 2: 165.25 – 165.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter (NaDC3) is a protein that in humans is encoded by the SLC13A3 gene. ^{[5] [6] [7]}

Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. ^[7]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000158296 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018459 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wang H, Fei YJ, Kekuda R, Yang-Feng TL, Devoe LD, Leibach FH, Prasad PD, Ganapathy V (Jun 2000). "Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter". Am J Physiol Cell Physiol. 278 (5): C1019–30. doi:10.1152/ajpcell.2000.278.5.C1019. PMID   10794676. S2CID   39532742.
6. Huang W, Wang H, Kekuda R, Fei YJ, Friedrich A, Wang J, Conway SJ, Cameron RS, Leibach FH, Ganapathy V (Nov 2000). "Transport of N-acetylaspartate by the Na(+)-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain". J Pharmacol Exp Ther. 295 (1): 392–403. PMID   10992006.
7. "Entrez Gene: SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3".

Further reading

• Markovich D, Murer H (2004). "The SLC13 gene family of sodium sulphate/carboxylate cotransporters". Pflügers Arch. 447 (5): 594–602. doi:10.1007/s00424-003-1128-6. PMID   12915942. S2CID   7609066.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Burckhardt BC, Lorenz J, Kobbe C, Burckhardt G (2005). "Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions". Am. J. Physiol. Renal Physiol. 288 (4): F792–9. doi:10.1152/ajprenal.00360.2004. PMID   15561973.
• Bai X, Chen X, Feng Z, et al. (2006). "Identification of basolateral membrane targeting signal of human sodium-dependent dicarboxylate transporter 3". J. Cell. Physiol. 206 (3): 821–30. doi: 10.1002/jcp.20553 . PMID   16331647. S2CID   37471691.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.