SLC25A39

SLC25A39
Identifiers
Aliases	SLC25A39 , CGI69, CGI-69, solute carrier family 25 member 39
External IDs	OMIM: 610820 MGI: 1196386 HomoloGene: 69200 GeneCards: SLC25A39
Gene location (Human)
Chr.	Chromosome 17 (human)
End	44,324,870 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	102,298,772 bp
RNA expression pattern
	Top expressed in
	blood; ; right lobe of thyroid gland; ; anterior pituitary; ; Right adrenal gland; ; left lobe of thyroid gland; ; body of pancreas; ; right lobe of liver; ; body of stomach; ; bone marrow; ; skin of abdomen;
	Top expressed in
	yolk sac; ; spermatocyte; ; spermatid; ; lip; ; superior frontal gyrus; ; proximal tubule; ; neural tube; ; morula; ; mirror; ; duodenum;
	More reference expression data
	n/a
Gene ontology
Molecular function	transmembrane transporter activity ;
Cellular component	membrane ; mitochondrion ; mitochondrial inner membrane ; integral component of membrane ;
Biological process	heme biosynthetic process ; mitochondrial transport ; transmembrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	51629
	68066
	ENSG00000013306
	ENSMUSG00000018677
	Q9BZJ4
	Q9D8K8
	NM_001143780 ; NM_016016 ; NM_001321240 ; NM_001321241 ; NM_001366726 Contents See also ; References ; Further reading ;
	NM_026542
	NP_001137252 ; NP_001308169 ; NP_001308170 ; NP_057100 ; NP_001353655
	NP_080818
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Solute carrier family 25 member 39 is a protein that in humans is encoded by the SLC25A39 gene.^[5]^[6] The protein has been shown to be necessary for the import of the major antioxidant glutathione into the mitochondria. ^[7]^[8]

Related Research Articles

Zinc transporter 8 (ZNT8) is a protein that in humans is encoded by the SLC30A8 gene. ZNT8 is a zinc transporter related to insulin secretion in humans. Certain alleles of the SLC30A8 gene may increase the risk for developing type 2 diabetes, but a loss-of-function mutation appears to greatly reduce the risk of diabetes.

Proton-coupled amino acid transporter 1 is a protein that in humans is encoded by the SLC36A1 gene.

Sodium-coupled neutral amino acid transporter 3 is a protein that in humans is encoded by the SLC38A3 gene.

Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene. It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.

Choline transporter-like protein 4 is a protein that in humans is encoded by the SLC44A4 gene.

Mitochondrial 2-oxoglutarate/malate carrier protein is a protein that in humans is encoded by the SLC25A11 gene. Inactivating mutations in this gene predispose to metastasic paraganglioma.

Brain mitochondrial carrier protein 1 is a protein that in humans is encoded by the SLC25A14 gene.

Mitochondrial uncoupling protein 4 is a protein that in humans is encoded by the SLC25A27 gene.

28S ribosomal protein L42, mitochondrial is a protein that in humans is encoded by the MRPL42 gene.

39S ribosomal protein L15, mitochondrial is a protein that in humans is encoded by the MRPL15 gene.

Mitochondrial thiamine pyrophosphate carrier is a protein that in humans is encoded by the SLC25A19 gene.

Zinc transporter 7 is a protein that in humans is encoded by the SLC30A7 gene.

39S ribosomal protein L18, mitochondrial is a protein that in humans is encoded by the MRPL18 gene.

Zinc transporter ZIP2 is a protein that in humans is encoded by the SLC39A2 gene.

Mitochondrial import receptor subunit TOM40B is a protein that in humans is encoded by the TOMM40L gene.

P3 protein is a protein that in humans is encoded by the SLC10A3 gene.

ADP/ATP translocase 4 (ANT4) is an enzyme that in humans is encoded by the SLC25A31 gene on chromosome 4. This enzyme inhibits apoptosis by catalyzing ADP/ATP exchange across the mitochondrial membranes and regulating membrane potential. In particular, ANT4 is essential to spermatogenesis, as it imports ATP into sperm mitochondria to support their development and survival. Outside this role, the SLC25AC31 gene has not been implicated in any human disease.

Sodium/bile acid cotransporter 7 is a protein which in humans is encoded by the SLC10A7 gene.

Long-chain fatty acid transport protein 3 is a protein that in humans is encoded by the SLC27A3 gene.

Solute carrier family 6, member 18 also known as SLC6A18 is a protein which in humans is encoded by the SLC6A18 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000013306 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018677 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Haitina T, Lindblom J, Renstrom T, Fredriksson R (Nov 2006). "Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system". Genomics. 88 (6): 779–90. doi: 10.1016/j.ygeno.2006.06.016 . PMID 16949250.
↑ "Entrez Gene: SLC25A39 solute carrier family 25, member 39".
↑ Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh H, Heissel S, Unlu G, Gamazon ER, Kharas MG, Hite R, Birsoy K (Nov 2021). "SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells". Nature. 599 (7883): 136–140. Bibcode:2021Natur.599..136W. doi:10.1038/s41586-021-04025-w. PMID 34707288. S2CID 240072540.
↑ "Scientists discover how mitochondria import antioxidants" . Retrieved January 22, 2022.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Yu XX, Lewin DA, Zhong A, et al. (2001). "Overexpression of the human 2-oxoglutarate carrier lowers mitochondrial membrane potential in HEK-293 cells: contrast with the unique cold-induced mitochondrial carrier CGI-69". Biochem. J. 353 (Pt 2): 369–75. doi:10.1042/0264-6021:3530369. PMC 1221580 . PMID 11139402.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876 . PMID 10810093.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000013306 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018677 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16949250-5] Haitina T, Lindblom J, Renstrom T, Fredriksson R (Nov 2006). "Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system". Genomics. 88 (6): 779–90. doi: 10.1016/j.ygeno.2006.06.016 . PMID 16949250.

[entrez-6] "Entrez Gene: SLC25A39 solute carrier family 25, member 39".

[7] Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh H, Heissel S, Unlu G, Gamazon ER, Kharas MG, Hite R, Birsoy K (Nov 2021). "SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells". Nature. 599 (7883): 136–140. Bibcode:2021Natur.599..136W. doi:10.1038/s41586-021-04025-w. PMID 34707288. S2CID 240072540.

[8] "Scientists discover how mitochondria import antioxidants" . Retrieved January 22, 2022.

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SLC25A39

Contents

See also

Related Research Articles

References

Further reading