SLC25A39

Last updated
SLC25A39
Identifiers
Aliases SLC25A39 , CGI69, CGI-69, solute carrier family 25 member 39
External IDs OMIM: 610820 MGI: 1196386 HomoloGene: 69200 GeneCards: SLC25A39
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001143780
NM_016016
NM_001321240
NM_001321241
NM_001366726

Contents

NM_026542

RefSeq (protein)

NP_001137252
NP_001308169
NP_001308170
NP_057100
NP_001353655

NP_080818

Location (UCSC) Chr 17: 44.32 – 44.32 Mb Chr 11: 102.29 – 102.3 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 25 member 39 is a protein that in humans is encoded by the SLC25A39 gene. [5] [6] The protein has been shown to be necessary for the import of the major antioxidant glutathione into the mitochondria. [7] [8]

See also

Related Research Articles

<span class="mw-page-title-main">Zinc transporter 8</span> Protein-coding gene in the species Homo sapiens

Zinc transporter 8 (ZNT8) is a protein that in humans is encoded by the SLC30A8 gene. ZNT8 is a zinc transporter related to insulin secretion in humans. Certain alleles of the SLC30A8 gene may increase the risk for developing type 2 diabetes, but a loss-of-function mutation appears to greatly reduce the risk of diabetes.

<span class="mw-page-title-main">Proton-coupled amino acid transporter 1</span> Protein-coding gene in the species Homo sapiens

Proton-coupled amino acid transporter 1 is a protein that in humans is encoded by the SLC36A1 gene.

<span class="mw-page-title-main">Sodium-coupled neutral amino acid transporter 3</span> Protein-coding gene in the species Homo sapiens

Sodium-coupled neutral amino acid transporter 3 is a protein that in humans is encoded by the SLC38A3 gene.

<span class="mw-page-title-main">SLC26A6</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene. It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.

<span class="mw-page-title-main">Choline transporter-like protein 4</span> Protein-coding gene in the species Homo sapiens

Choline transporter-like protein 4 is a protein that in humans is encoded by the SLC44A4 gene.

<span class="mw-page-title-main">Mitochondrial 2-oxoglutarate/malate carrier protein</span> Mammalian protein found in Homo sapiens

Mitochondrial 2-oxoglutarate/malate carrier protein is a protein that in humans is encoded by the SLC25A11 gene. Inactivating mutations in this gene predispose to metastasic paraganglioma.

<span class="mw-page-title-main">Brain mitochondrial carrier protein 1</span> Protein-coding gene in the species Homo sapiens

Brain mitochondrial carrier protein 1 is a protein that in humans is encoded by the SLC25A14 gene.

<span class="mw-page-title-main">Mitochondrial uncoupling protein 4</span> Protein-coding gene in the species Homo sapiens

Mitochondrial uncoupling protein 4 is a protein that in humans is encoded by the SLC25A27 gene.

<span class="mw-page-title-main">Mitochondrial ribosomal protein L42</span> Protein-coding gene in the species Homo sapiens

28S ribosomal protein L42, mitochondrial is a protein that in humans is encoded by the MRPL42 gene.

<span class="mw-page-title-main">Mitochondrial ribosomal protein L15</span> Protein-coding gene in the species Homo sapiens

39S ribosomal protein L15, mitochondrial is a protein that in humans is encoded by the MRPL15 gene.

<span class="mw-page-title-main">Mitochondrial thiamine pyrophosphate carrier</span> Protein-coding gene in the species Homo sapiens

Mitochondrial thiamine pyrophosphate carrier is a protein that in humans is encoded by the SLC25A19 gene.

<span class="mw-page-title-main">Zinc transporter 7</span> Protein-coding gene in the species Homo sapiens

Zinc transporter 7 is a protein that in humans is encoded by the SLC30A7 gene.

<span class="mw-page-title-main">Mitochondrial ribosomal protein L18</span> Protein-coding gene in the species Homo sapiens

39S ribosomal protein L18, mitochondrial is a protein that in humans is encoded by the MRPL18 gene.

<span class="mw-page-title-main">Zinc transporter ZIP2</span> Protein-coding gene in the species Homo sapiens

Zinc transporter ZIP2 is a protein that in humans is encoded by the SLC39A2 gene.

<span class="mw-page-title-main">TOMM40L</span> Protein-coding gene in the species Homo sapiens

Mitochondrial import receptor subunit TOM40B is a protein that in humans is encoded by the TOMM40L gene.

<span class="mw-page-title-main">P3 protein</span> Protein-coding gene in the species Homo sapiens

P3 protein is a protein that in humans is encoded by the SLC10A3 gene.

<span class="mw-page-title-main">ADP/ATP translocase 4</span> Protein-coding gene in the species Homo sapiens

ADP/ATP translocase 4 (ANT4) is an enzyme that in humans is encoded by the SLC25A31 gene on chromosome 4. This enzyme inhibits apoptosis by catalyzing ADP/ATP exchange across the mitochondrial membranes and regulating membrane potential. In particular, ANT4 is essential to spermatogenesis, as it imports ATP into sperm mitochondria to support their development and survival. Outside this role, the SLC25AC31 gene has not been implicated in any human disease.

<span class="mw-page-title-main">Sodium/bile acid cotransporter 7</span> Protein-coding gene in the species Homo sapiens

Sodium/bile acid cotransporter 7 is a protein which in humans is encoded by the SLC10A7 gene.

<span class="mw-page-title-main">SLC27A3</span> Protein-coding gene in the species Homo sapiens

Long-chain fatty acid transport protein 3 is a protein that in humans is encoded by the SLC27A3 gene.

<span class="mw-page-title-main">SLC6A18</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 6, member 18 also known as SLC6A18 is a protein which in humans is encoded by the SLC6A18 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000013306 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018677 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Haitina T, Lindblom J, Renstrom T, Fredriksson R (Nov 2006). "Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system". Genomics. 88 (6): 779–90. doi: 10.1016/j.ygeno.2006.06.016 . PMID   16949250.
  6. "Entrez Gene: SLC25A39 solute carrier family 25, member 39".
  7. Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh H, Heissel S, Unlu G, Gamazon ER, Kharas MG, Hite R, Birsoy K (Nov 2021). "SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells". Nature. 599 (7883): 136–140. Bibcode:2021Natur.599..136W. doi:10.1038/s41586-021-04025-w. PMID   34707288. S2CID   240072540.
  8. "Scientists discover how mitochondria import antioxidants" . Retrieved January 22, 2022.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.