SLC25A39

SLC25A39
Identifiers
Aliases	SLC25A39 , CGI69, CGI-69, solute carrier family 25 member 39
External IDs	OMIM: 610820; MGI: 1196386; HomoloGene: 69200; GeneCards: SLC25A39; OMA:SLC25A39 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.31 Start 44,319,625 bp [1] End 44,324,870 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 D|11 66.29 cM Start 102,293,811 bp [2] End 102,298,772 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood mucosa of transverse colon right lobe of thyroid gland anterior pituitary right testis right adrenal gland left lobe of thyroid gland right adrenal cortex body of pancreas left adrenal cortex Top expressed in right kidney yolk sac embryo spermatocyte spermatid lip embryo ventricular zone dentate gyrus of hippocampal formation granule cell muscle of thigh More reference expression data BioGPS n/a
Gene ontology Molecular function transmembrane transporter activity Cellular component membrane mitochondrion mitochondrial inner membrane integral component of membrane Biological process heme biosynthetic process mitochondrial transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51629 68066 Ensembl ENSG00000013306 ENSMUSG00000018677 UniProt Q9BZJ4 Q9D8K8 RefSeq (mRNA) NM_001143780 NM_016016 NM_001321240 NM_001321241 NM_001366726 NM_026542 RefSeq (protein) NP_001137252 NP_001308169 NP_001308170 NP_057100 NP_001353655 NP_080818 Location (UCSC) Chr 17: 44.32 – 44.32 Mb Chr 11: 102.29 – 102.3 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 25 member 39 is a protein that in humans is encoded by the SLC25A39 gene. ^{[5] [6]} The protein has been shown to be necessary for the import of the major antioxidant glutathione into the mitochondria. ^{[7] [8]}

See also

• SLC25A39+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

References

1. GRCh38: Ensembl release 89: ENSG00000013306 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018677 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Haitina T, Lindblom J, Renstrom T, Fredriksson R (Nov 2006). "Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system". Genomics. 88 (6): 779–90. doi: 10.1016/j.ygeno.2006.06.016 . PMID   16949250.
6. "Entrez Gene: SLC25A39 solute carrier family 25, member 39".
7. Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh H, Heissel S, Unlu G, Gamazon ER, Kharas MG, Hite R, Birsoy K (Nov 2021). "SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells". Nature. 599 (7883): 136–140. Bibcode:2021Natur.599..136W. doi:10.1038/s41586-021-04025-w. PMC   10981497 . PMID   34707288. S2CID   240072540.
8. "Scientists discover how mitochondria import antioxidants" . Retrieved January 22, 2022.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Yu XX, Lewin DA, Zhong A, et al. (2001). "Overexpression of the human 2-oxoglutarate carrier lowers mitochondrial membrane potential in HEK-293 cells: contrast with the unique cold-induced mitochondrial carrier CGI-69". Biochem. J. 353 (Pt 2): 369–75. doi:10.1042/0264-6021:3530369. PMC   1221580 . PMID   11139402.
• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC   310876 . PMID   10810093.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.