Chloride potassium symporter 4

SLC12A4
Identifiers
Aliases	SLC12A4 , KCC1, Chloride potassium symporter 4, CTC-479C5.17, hKCC1, solute carrier family 12 member 4
External IDs	OMIM: 604119; MGI: 1309465; HomoloGene: 21056; GeneCards: SLC12A4; OMA:SLC12A4 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q22.1 Start 67,943,474 bp [1] End 67,969,601 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 D3|8 53.06 cM Start 106,670,222 bp [2] End 106,692,729 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart ascending aorta stromal cell of endometrium body of uterus Descending thoracic aorta right coronary artery left lobe of thyroid gland left coronary artery tibial nerve tibial arteries Top expressed in choroid plexus of fourth ventricle molar Epithelium of choroid plexus lip ankle stroma of bone marrow body of femur yolk sac sciatic nerve calvaria More reference expression data BioGPS n/a
Gene ontology Molecular function cation:chloride symporter activity symporter activity transporter activity protein kinase binding potassium:chloride symporter activity Cellular component lysosomal membrane plasma membrane membrane integral component of membrane integral component of plasma membrane Biological process ion transport chemical synaptic transmission cell volume homeostasis potassium ion transport potassium ion transmembrane transport transmembrane transport chloride transmembrane transport chloride transport transport chloride ion homeostasis potassium ion homeostasis potassium ion import across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6560 20498 Ensembl ENSG00000124067 ENSMUSG00000017765 UniProt Q9UP95 Q9JIS8 RefSeq (mRNA) NM_005072 NM_001145961 NM_001145962 NM_001145963 NM_001145964 NM_001253804 NM_009195 RefSeq (protein) NP_001139433 NP_001139434 NP_001139435 NP_001139436 NP_005063 NP_001240733 NP_033221 Location (UCSC) Chr 16: 67.94 – 67.97 Mb Chr 8: 106.67 – 106.69 Mb PubMed search [3] [4]
Wikidata
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Potassium-chloride transporter, member 4 is a chloride potassium symporter protein. It is encoded by the gene SLC12A4. ^[5]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000124067 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000017765 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SLC12A4 solute carrier family 12 (potassium/chloride transporters), member 4".

Further reading

• Larsen F, Solheim J, Kristensen T, et al. (1994). "A tight cluster of five unrelated human genes on chromosome 16q22.1". Hum. Mol. Genet. 2 (10): 1589–95. doi:10.1093/hmg/2.10.1589. PMID   8268911.
• Gillen CM, Brill S, Payne JA, Forbush B (1996). "Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family". J. Biol. Chem. 271 (27): 16237–44. doi: 10.1074/jbc.271.27.16237 . PMID   8663127.
• Pellegrino CM, Rybicki AC, Musto S, et al. (1998). "Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells". Blood Cells Mol. Dis. 24 (1): 31–40. doi:10.1006/bcmd.1998.0168. PMID   9516379.
• Su W, Shmukler BE, Chernova MN, et al. (1999). "Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation". Am. J. Physiol. 277 (5 Pt 1): C899–912. doi:10.1152/ajpcell.1999.277.5.C899. PMID   10564083.
• Casula S, Shmukler BE, Wilhelm S, et al. (2001). "A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity". J. Biol. Chem. 276 (45): 41870–8. doi: 10.1074/jbc.M107155200 . PMID   11551954.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bräuer M, Frei E, Claes L, et al. (2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl⁻ channels in human osteoblasts". Am. J. Physiol., Cell Physiol. 285 (1): C22–30. doi:10.1152/ajpcell.00289.2002. PMID   12637262.
• Shen MR, Chou CY, Hsu KF, et al. (2003). "KCl cotransport is an important modulator of human cervical cancer growth and invasion". J. Biol. Chem. 278 (41): 39941–50. doi: 10.1074/jbc.M308232200 . PMID   12902337.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Zhou GP, Wong C, Su R, et al. (2004). "Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element". Blood. 103 (11): 4302–9. doi: 10.1182/blood-2003-01-0107 . PMID   14976052.
• Khan AI, Drew C, Ball SE, et al. (2005). "Oxygen dependence of K⁺–Cl⁻ cotransport in human red cell ghosts and sickle cells". Bioelectrochemistry. 62 (2): 141–6. doi:10.1016/j.bioelechem.2003.07.005. PMID   15039017.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Shen MR, Lin AC, Hsu YM, et al. (2004). "Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells". J. Biol. Chem. 279 (38): 40017–25. doi: 10.1074/jbc.M406706200 . PMID   15262997.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.