SLC27A5

Last updated
SLC27A5
Identifiers
Aliases SLC27A5 , ACSB, ACSVL6, BACS, BAL, FACVL3, FATP-5, FATP5, VLACSR, VLCS-H2, VLCSH2, solute carrier family 27 member 5
External IDs OMIM: 603314 MGI: 1347100 HomoloGene: 7596 GeneCards: SLC27A5
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012254
NM_001321196

NM_009512

RefSeq (protein)

NP_001308125
NP_036386

NP_033538

Location (UCSC) Chr 19: 58.48 – 58.51 Mb Chr 7: 12.72 – 12.73 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Bile acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A5 gene. [5] [6] [7]

Contents

The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [7]

See also

Related Research Articles

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<span class="mw-page-title-main">Long-chain-fatty-acid—CoA ligase</span> Class of enzymes

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<span class="mw-page-title-main">ACSL6</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">ACSL5</span> Protein-coding gene in the species Homo sapiens

Long-chain-fatty-acid—CoA ligase 5 is an enzyme that in humans is encoded by the ACSL5 gene.

<span class="mw-page-title-main">ACSL3</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">ACOT2</span> Protein-coding gene in the species Homo sapiens

Acyl-CoA thioesterase 2, also known as ACOT2, is an enzyme which in humans is encoded by the ACOT2 gene.

<span class="mw-page-title-main">Very long-chain acyl-CoA synthetase</span> Protein-coding gene in the species Homo sapiens

Very long-chain acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A2 gene.

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Long-chain fatty acid transport protein 4 is a protein that in humans is encoded by the SLC27A4 gene. This membrane protein is also called FATP4 or ACSVL5. The purified protein shows enzyme activity, esterifying long and very long chain fatty acids with Coenzyme A. It is debated whether it is also a fatty acid transporter at the plasma membrane.

<span class="mw-page-title-main">ACSBG1</span> Protein-coding gene in the species Homo sapiens

Acyl-CoA Synthetase, Bubblegum Family, member 1 (ACSBG1) is an enzyme that in humans is encoded by the ACSBG1 gene.

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<span class="mw-page-title-main">ACOT11</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">SLC27A6</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Acyl-CoA thioesterase 9</span> Protein-coding gene in humans

Acyl-CoA thioesterase 9 is a protein that is encoded by the human ACOT9 gene. It is a member of the acyl-CoA thioesterase superfamily, which is a group of enzymes that hydrolyze Coenzyme A esters. There is no known function, however it has been shown to act as a long-chain thioesterase at low concentrations, and a short-chain thioesterase at high concentrations.

<span class="mw-page-title-main">ACOT13</span> Protein-coding gene in the species Homo sapiens

Acyl-CoA thioesterase 13 is a protein that in humans is encoded by the ACOT13 gene. This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation.

<span class="mw-page-title-main">ACOT1</span> Protein-coding gene in the species Homo sapiens

Acyl-CoA thioesterase 1 is a protein that in humans is encoded by the ACOT1 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000083807 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030382 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Steinberg SJ, Wang SJ, McGuinness MC, Watkins PA (Oct 1999). "Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein". Mol Genet Metab. 68 (1): 32–42. doi: 10.1006/mgme.1999.2883 . PMID   10479480.
  6. Steinberg SJ, Mihalik SJ, Kim DG, Cuebas DA, Watkins PA (Jun 2000). "The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase". J Biol Chem. 275 (21): 15605–8. doi: 10.1074/jbc.C000015200 . PMID   10749848.
  7. 1 2 "Entrez Gene: SLC27A5 solute carrier family 27 (fatty acid transporter), member 5".

Further reading