SLC2A12

SLC2A12
Identifiers
Aliases	SLC2A12 , GLUT12, GLUT8, solute carrier family 2 member 12
External IDs	OMIM: 610372 MGI: 3052471 HomoloGene: 59263 GeneCards: SLC2A12
Gene location (Human)
Chr.	Chromosome 6 (human)
End	134,052,624 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	22,580,184 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; retinal pigment epithelium; ; duodenum; ; prostate; ; bronchial epithelial cell; ; body of stomach; ; biceps brachii; ; cardia; ; cavity of mouth; ; seminal vesicula;
	Top expressed in
	secondary oocyte; ; retinal pigment epithelium; ; stellate ganglion; ; Greater petrosal nerve; ; uterus; ; otolith organ; ; utricle; ; sternocleidomastoid muscle; ; cervix; ; submandibular gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	glucose transmembrane transporter activity ; carbohydrate:proton symporter activity ; transmembrane transporter activity ; transporter activity ; D-glucose transmembrane transporter activity ;
Cellular component	cytoplasm ; perinuclear region of cytoplasm ; integral component of membrane ; plasma membrane ; membrane ; endomembrane system ; integral component of plasma membrane ;
Biological process	carbohydrate transport ; glucose import ; transmembrane transport ; hexose transmembrane transport ; proton transmembrane transport ; glucose transmembrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	154091
	353169
	ENSG00000146411
	ENSMUSG00000037490
	Q8TD20
	Q8BFW9
	NM_145176
	NM_178934
	NP_660159
	NP_849265
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 13, 2023

Solute carrier family 2, facilitated glucose transporter member 12 is a protein that in humans is encoded by the SLC2A12 gene.^[5]^[6]^[7]

Related Research Articles

Glucose transporter 3, also known as solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) is a protein that in humans is encoded by the SLC2A3 gene. GLUT3 facilitates the transport of glucose across the plasma membranes of mammalian cells. GLUT3 is most known for its specific expression in neurons and has originally been designated as the neuronal GLUT. GLUT3 has been studied in other cell types with specific glucose requirements, including sperm, preimplantation embryos, circulating white blood cells and carcinoma cell lines.

Thiamine transporter 2 (ThTr-2), also known as solute carrier family 19 member 3, is a protein that in humans is encoded by the SLC19A3 gene. SLC19A3 is a thiamine transporter.

GLUT5 is a fructose transporter expressed on the apical border of enterocytes in the small intestine. GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose's high concentration in the intestinal lumen. GLUT5 is also expressed in skeletal muscle, testis, kidney, fat tissue (adipocytes), and brain.

Sodium-coupled neutral amino acid transporter 2 is a protein that in humans is encoded by the SLC38A2 gene.

Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene. It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.

Solute carrier family 2, facilitated glucose transporter member 10 is a protein that in humans is encoded by the SLC2A10 gene.

Multidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47 member 1, is a protein that in humans is encoded by the SLC47A1 gene. SLC47A1 belongs to the MATE family of transporters that are found in bacteria, archaea and eukaryotes.

Urea transporter 2 is a protein that in humans is encoded by the SLC14A2 gene.

Solute carrier family 2, facilitated glucose transporter member 6 is a protein that in humans is encoded by the SLC2A6 gene.

Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (SLC6A14) is a protein that in humans is encoded by the SLC6A14 gene.

Solute carrier organic anion transporter family member 2B1 also known as organic anion-transporting polypeptide 2B1 (OATP2B1) is a protein that in humans is encoded by the gene SLCO2B1.

Sodium-coupled monocarboxylate transporter 1 is a protein that in humans is encoded by the SLC5A8 gene.

Solute carrier family 2, facilitated glucose transporter member 9 is a protein that in humans is encoded by the SLC2A9 gene.

Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter (NaDC3) is a protein that in humans is encoded by the SLC13A3 gene.

Solute carrier family 22 member 9 is a protein that in humans is encoded by the SLC22A9 gene.

Solute carrier family 2, facilitated glucose transporter member 7 also known as glucose transporter 7 (GLUT7) is a protein that in humans is encoded by the SLC2A7 gene.

Asc-type amino acid transporter 1 (Asc-1) is a protein that in humans is encoded by the SLC7A10 gene.

Solute carrier family 22 member 25 (SLC22A25), also known as organic anion transporter UST6, is a protein that in humans is encoded by the SLC22A25 gene.

Monocarboxylate transporter 10, also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 (TAT1) and solute carrier family 16 member 10 (SLC16A10), is a protein that in humans is encoded by the SLC16A10 gene. SLC16A10 is a member of the solute carrier family.

Solute carrier family 2, member 14 is a protein that in humans is encoded by the SLC2A14 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000146411 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037490 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Joost HG, Thorens B (Jan 2002). "The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review)". Mol Membr Biol. 18 (4): 247–56. doi: 10.1080/09687680110090456 . PMID 11780753. S2CID 22667943.
↑ Rogers S, Macheda ML, Docherty SE, Carty MD, Henderson MA, Soeller WC, Gibbs EM, James DE, Best JD (Feb 2002). "Identification of a novel glucose transporter-like protein-GLUT-12". Am J Physiol Endocrinol Metab. 282 (3): E733–8. doi:10.1152/ajpendo.2002.282.3.E733. PMID 11832379. S2CID 22919544.
↑ "Entrez Gene: SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12".

Baumann MU, Deborde S, Illsley NP (2003). "Placental glucose transfer and fetal growth". Endocrine. 19 (1): 13–22. doi:10.1385/ENDO:19:1:13. PMID 12583599. S2CID 26301249.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Wood IS, Hunter L, Trayhurn P (2003). "Expression of Class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues". Biochem. Biophys. Res. Commun. 308 (1): 43–9. doi:10.1016/S0006-291X(03)01322-6. PMID 12890477.
Rogers S, Chandler JD, Clarke AL, et al. (2003). "Glucose transporter GLUT12-functional characterization in Xenopus laevis oocytes". Biochem. Biophys. Res. Commun. 308 (3): 422–6. doi:10.1016/S0006-291X(03)01417-7. PMID 12914765.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Linden KC, DeHaan CL, Zhang Y, et al. (2006). "Renal expression and localization of the facilitative glucose transporters GLUT1 and GLUT12 in animal models of hypertension and diabetic nephropathy". Am. J. Physiol. Renal Physiol. 290 (1): F205–13. doi:10.1152/ajprenal.00237.2004. PMID 16091581.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Stuart CA, Yin D, Howell ME, et al. (2006). "Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle". Am. J. Physiol. Endocrinol. Metab. 291 (5): E1067–73. doi:10.1152/ajpendo.00250.2006. PMID 16803853. S2CID 41473791.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000146411 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037490 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11780753-5] Joost HG, Thorens B (Jan 2002). "The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review)". Mol Membr Biol. 18 (4): 247–56. doi: 10.1080/09687680110090456 . PMID 11780753. S2CID 22667943.

[pmid11832379-6] Rogers S, Macheda ML, Docherty SE, Carty MD, Henderson MA, Soeller WC, Gibbs EM, James DE, Best JD (Feb 2002). "Identification of a novel glucose transporter-like protein-GLUT-12". Am J Physiol Endocrinol Metab. 282 (3): E733–8. doi:10.1152/ajpendo.2002.282.3.E733. PMID 11832379. S2CID 22919544.

[entrez-7] "Entrez Gene: SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12".

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SLC2A12

Contents

See also

Related Research Articles

References

Further reading