SLC2A12

SLC2A12
Identifiers
Aliases	SLC2A12 , GLUT12, GLUT8, solute carrier family 2 member 12
External IDs	OMIM: 610372; MGI: 3052471; HomoloGene: 59263; GeneCards: SLC2A12; OMA:SLC2A12 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q23.2 Start 133,987,581 bp [1] End 134,052,624 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 A3 Start 22,520,910 bp [2] End 22,580,184 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa retinal pigment epithelium myocardium of left ventricle buccal mucosa cell duodenum tail of epididymis prostate bronchial epithelial cell epithelium of nasopharynx body of stomach Top expressed in Epithelium of choroid plexus gastrula otic vesicle lobe of prostate secondary oocyte retinal pigment epithelium lumbar subsegment of spinal cord zygote stellate ganglion greater petrosal nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glucose transmembrane transporter activity carbohydrate:proton symporter activity transmembrane transporter activity transporter activity D-glucose transmembrane transporter activity Cellular component cytoplasm perinuclear region of cytoplasm integral component of membrane plasma membrane membrane endomembrane system integral component of plasma membrane Biological process carbohydrate transport glucose import transmembrane transport hexose transmembrane transport proton transmembrane transport glucose transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 154091 353169 Ensembl ENSG00000146411 ENSMUSG00000037490 UniProt Q8TD20 Q8BFW9 RefSeq (mRNA) NM_145176 NM_178934 RefSeq (protein) NP_660159 NP_849265 Location (UCSC) Chr 6: 133.99 – 134.05 Mb Chr 10: 22.52 – 22.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 2, facilitated glucose transporter member 12 is a protein that in humans is encoded by the SLC2A12 gene. ^{[5] [6] [7]}

See also

• Glucose transporter
• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000146411 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037490 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Joost HG, Thorens B (Jan 2002). "The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review)". Mol Membr Biol. 18 (4): 247–56. doi: 10.1080/09687680110090456 . PMID   11780753. S2CID   22667943.
6. Rogers S, Macheda ML, Docherty SE, Carty MD, Henderson MA, Soeller WC, Gibbs EM, James DE, Best JD (Feb 2002). "Identification of a novel glucose transporter-like protein-GLUT-12". Am J Physiol Endocrinol Metab. 282 (3): E733–8. doi:10.1152/ajpendo.2002.282.3.E733. PMID   11832379. S2CID   22919544.
7. "Entrez Gene: SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12".

Further reading

• Baumann MU, Deborde S, Illsley NP (2003). "Placental glucose transfer and fetal growth". Endocrine. 19 (1): 13–22. doi:10.1385/ENDO:19:1:13. PMID   12583599. S2CID   26301249.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wood IS, Hunter L, Trayhurn P (2003). "Expression of Class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues". Biochem. Biophys. Res. Commun. 308 (1): 43–9. doi:10.1016/S0006-291X(03)01322-6. PMID   12890477.
• Rogers S, Chandler JD, Clarke AL, et al. (2003). "Glucose transporter GLUT12-functional characterization in Xenopus laevis oocytes". Biochem. Biophys. Res. Commun. 308 (3): 422–6. doi:10.1016/S0006-291X(03)01417-7. PMID   12914765.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Linden KC, DeHaan CL, Zhang Y, et al. (2006). "Renal expression and localization of the facilitative glucose transporters GLUT1 and GLUT12 in animal models of hypertension and diabetic nephropathy". Am. J. Physiol. Renal Physiol. 290 (1): F205–13. doi:10.1152/ajprenal.00237.2004. PMID   16091581.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Stuart CA, Yin D, Howell ME, et al. (2006). "Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle". Am. J. Physiol. Endocrinol. Metab. 291 (5): E1067–73. doi:10.1152/ajpendo.00250.2006. PMID   16803853. S2CID   41473791.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.