SLC5A4

SLC5A4
Identifiers
Aliases	SLC5A4 , DJ90G24.4, SAAT1, SGLT3, solute carrier family 5 member 4
External IDs	MGI: 1927848; HomoloGene: 8591; GeneCards: SLC5A4; OMA:SLC5A4 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q12.3 Start 32,218,464 bp [1] End 32,255,347 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 C1 Start 75,983,285 bp [2] End 76,025,099 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum testicle islet of Langerhans smooth muscle tissue upper lobe of left lung body of uterus sural nerve right lung left lobe of thyroid gland right lobe of thyroid gland Top expressed in morula jejunum intestinal villus duodenum lumbar subsegment of spinal cord proximal tubule cumulus cell ileum right kidney ovary More reference expression data BioGPS n/a
Gene ontology Molecular function glucose:sodium symporter activity transmembrane transporter activity Cellular component integral component of membrane membrane integral component of plasma membrane plasma membrane Biological process ion transport transmembrane transport sodium ion transport glucose transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6527 64452 Ensembl ENSG00000100191 ENSMUSG00000020229 UniProt Q9NY91 Q9ET37 RefSeq (mRNA) NM_014227 NM_133184 RefSeq (protein) NP_055042 NP_573447 Location (UCSC) Chr 22: 32.22 – 32.26 Mb Chr 10: 75.98 – 76.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The low affinity sodium-glucose cotransporter also known as the sodium/glucose cotransporter 3 (SGLT3) or solute carrier family 5 member 4 (SLC5A4) is a protein that in humans is encoded by the SLC5A4 gene. ^{[5] [6] [7]} It functions as a sugar sensor.

References

1. GRCh38: Ensembl release 89: ENSG00000100191 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020229 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: solute carrier family 5 (low affinity glucose cotransporter)".
6. Veyhl M, Wagner K, Volk C, Gorboulev V, Baumgarten K, Weber WM, Schaper M, Bertram B, Wiessler M, Koepsell H (March 1998). "Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1". Proceedings of the National Academy of Sciences of the United States of America. 95 (6): 2914–9. Bibcode:1998PNAS...95.2914V. doi: 10.1073/pnas.95.6.2914 . PMC   19669 . PMID   9501190.
7. Jung H (October 2002). "The sodium/substrate symporter family: structural and functional features". FEBS Letters. 529 (1): 73–7. doi: 10.1016/S0014-5793(02)03184-8 . PMID   12354616.

Further reading

• Munafò MR, Clark TG, Roberts KH, Johnstone EC (2006). "Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression". Neuropsychobiology. 53 (1): 1–8. doi:10.1159/000089915. PMID   16319503. S2CID   12803994.
• Blaya C, Salum GA, Lima MS, Leistner-Segal S, Manfro GG (2007). "Lack of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Panic Disorder: a systematic review and meta-analysis". Behavioral and Brain Functions. 3: 41. doi: 10.1186/1744-9081-3-41 . PMC   1994953 . PMID   17705872.
• Diez-Sampedro A, Hirayama BA, Osswald C, Gorboulev V, Baumgarten K, Volk C, Wright EM, Koepsell H (September 2003). "A glucose sensor hiding in a family of transporters". Proceedings of the National Academy of Sciences of the United States of America. 100 (20): 11753–8. Bibcode:2003PNAS..10011753D. doi: 10.1073/pnas.1733027100 . PMC   208830 . PMID   13130073.
• Fairchild TJ (January 2008). "Protection of muscle membrane excitability during cycling in humans: a role for SGLT3?". Journal of Applied Physiology. 104 (1): 315, author reply 316. doi:10.1152/japplphysiol.00793.2007. PMID   18198291. S2CID   29443314.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Voss AA, Díez-Sampedro A, Hirayama BA, Loo DD, Wright EM (February 2007). "Imino sugars are potent agonists of the human glucose sensor SGLT3". Molecular Pharmacology. 71 (2): 628–34. doi:10.1124/mol.106.030288. PMID   17110502. S2CID   13642065.