SLC23A2

SLC23A2
Identifiers
Aliases	SLC23A2 , NBTL1, SLC23A1, SVCT2, YSPL2, hSVCT2, solute carrier family 23 member 2
External IDs	OMIM: 603791; MGI: 1859682; HomoloGene: 68440; GeneCards: SLC23A2; OMA:SLC23A2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p13 Start 4,852,356 bp [1] End 5,010,293 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 F2 Start 131,894,416 bp [2] End 131,987,028 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal cortex lateral nuclear group of thalamus Brodmann area 10 Epithelium of choroid plexus paraflocculus of cerebellum cerebellar vermis pars compacta right lobe of liver subthalamic nucleus Top expressed in choroid plexus of fourth ventricle secondary oocyte gastrula zygote primary visual cortex perirhinal cortex CA3 field entorhinal cortex Epithelium of choroid plexus superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleobase transmembrane transporter activity transporter activity L-ascorbate:sodium symporter activity symporter activity L-ascorbic acid transmembrane transporter activity transmembrane transporter activity Cellular component cytoplasm membrane basal plasma membrane basolateral plasma membrane apical plasma membrane plasma membrane integral component of plasma membrane integral component of membrane contractile fiber Biological process sodium ion transport ion transport response to oxidative stress L-ascorbic acid transmembrane transport nucleobase transport transmembrane transport nucleobase-containing compound metabolic process L-ascorbic acid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9962 54338 Ensembl ENSG00000089057 ENSMUSG00000027340 UniProt Q9UGH3 Q9EPR4 RefSeq (mRNA) NM_005116 NM_203327 NM_018824 NM_001355430 NM_001355431 RefSeq (protein) NP_005107 NP_976072 NP_061294 NP_001342359 NP_001342360 Location (UCSC) Chr 20: 4.85 – 5.01 Mb Chr 2: 131.89 – 131.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 23 member 2 is a protein that in humans is encoded by the SLC23A2 gene. ^{[5] [6] [7]}

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. ^[7]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000089057 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027340 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Faaland CA, Race JE, Ricken G, Warner FJ, Williams WJ, Holtzman EJ (Dec 1998). "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters". Biochim Biophys Acta. 1442 (2–3): 353–60. doi:10.1016/S0167-4781(98)00151-1. PMID   9804989.
6. Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA (Jun 1999). "A family of mammalian Na+-dependent L-ascorbic acid transporters". Nature. 399 (6731): 70–5. Bibcode:1999Natur.399...70T. doi:10.1038/19986. PMID   10331392. S2CID   4425479.
7. "Entrez Gene: SLC23A2 solute carrier family 23 (nucleobase transporters), member 2".

Further reading

• Liang WJ, Johnson D, Jarvis SM (2001). "Vitamin C transport systems of mammalian cells". Mol. Membr. Biol. 18 (1): 87–95. doi: 10.1080/09687680110033774 . PMID   11396616. S2CID   22478598.
• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi: 10.1093/dnares/3.5.321 . PMID   9039502.
• Hogue DL, Ling V (1999). "A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals". Genomics. 59 (1): 18–23. doi:10.1006/geno.1999.5847. PMID   10395795.
• Rajan DP, Huang W, Dutta B, et al. (1999). "Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function". Biochem. Biophys. Res. Commun. 262 (3): 762–8. doi:10.1006/bbrc.1999.1272. PMID   10471399.
• Daruwala R, Song J, Koh WS, et al. (1999). "Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2". FEBS Lett. 460 (3): 480–4. doi: 10.1016/S0014-5793(99)01393-9 . PMID   10556521. S2CID   37936975.
• Breton S, Wiederhold T, Marshansky V, et al. (2000). "The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells". J. Biol. Chem. 275 (24): 18219–24. doi: 10.1074/jbc.M909857199 . PMID   10748165.
• Holliday LS, Lu M, Lee BS, et al. (2000). "The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site". J. Biol. Chem. 275 (41): 32331–7. doi: 10.1074/jbc.M004795200 . PMID   10915794.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Hediger MA (2002). "New view at C.". Nat. Med. 8 (5): 445–6. doi:10.1038/nm0502-445. PMID   11984580. S2CID   787845.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Fischer H, Schwarzer C, Illek B (2004). "Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3691–6. Bibcode:2004PNAS..101.3691F. doi: 10.1073/pnas.0308393100 . PMC   373524 . PMID   14993613.
• Lutsenko EA, Carcamo JM, Golde DW (2004). "A human sodium-dependent vitamin C transporter 2 isoform acts as a dominant-negative inhibitor of ascorbic acid transport". Mol. Cell. Biol. 24 (8): 3150–6. doi:10.1128/MCB.24.8.3150-3156.2004. PMC   381605 . PMID   15060139.
• Seno T, Inoue N, Matsui K, et al. (2004). "Functional expression of sodium-dependent vitamin C transporter 2 in human endothelial cells". J. Vasc. Res. 41 (4): 345–51. doi:10.1159/000080525. PMID   15340249. S2CID   20754421.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• McNulty AL, Vail TP, Kraus VB (2005). "Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2". Biochim. Biophys. Acta. 1712 (2): 212–21. doi:10.1016/j.bbamem.2005.04.009. PMID   15921655.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.