SLC41A3

SLC41A3
Identifiers
Aliases	SLC41A3 , SLC41A1-L2, solute carrier family 41 member 3
External IDs	OMIM: 610803 MGI: 1918949 HomoloGene: 23052 GeneCards: SLC41A3
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q21.2-q21.3 Start 126,006,357 bp [1] End 126,101,561 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 D1 Start 90,581,707 bp [2] End 90,623,394 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex ascending aorta middle temporal gyrus Left adrenal gland amygdala right coronary artery anterior pituitary Brodmann area 9 popliteal artery gastrocnemius muscle Top expressed in interventricular septum right ventricle triceps brachii muscle sternocleidomastoid muscle digastric muscle extraocular muscle temporal muscle quadriceps femoris muscle vastus lateralis muscle tibialis anterior muscle More reference expression data BioGPS n/a
Gene ontology Molecular function cation transmembrane transporter activity protein binding Cellular component integral component of membrane membrane plasma membrane Biological process cation transport cation transmembrane transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54946 71699 Ensembl ENSG00000114544 ENSMUSG00000030089 UniProt Q96GZ6 Q921R8 RefSeq (mRNA) NM_001008485 NM_001008486 NM_001008487 NM_001164475 NM_017836 NM_001037493 NM_027868 RefSeq (protein) NP_001008485 NP_001008486 NP_001008487 NP_001157947 NP_060306 NP_001008486.1 NP_001032570 NP_082144 Location (UCSC) Chr 3: 126.01 – 126.1 Mb Chr 6: 90.58 – 90.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 41, member 3 is a protein that in humans is encoded by the SLC41A3 gene. ^[5]

Model organisms

Slc41a3 knockout mouse phenotype

Characteristic	Phenotype
Homozygote viability	Normal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Abnormal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Plasma immunoglobulins	Normal
Haematology	Normal
Micronucleus test	Normal
Heart weight	Normal
Tail epidermis wholemount	Normal
Skin Histopathology	Normal
Brain histopathology	Normal
Eye Histopathology	Normal
Salmonella infection	Normal [6]
Citrobacter infection	Normal [7]
All tests and analysis from [8] [9]

Model organisms have been used in the study of SLC41A3 function. A conditional knockout mouse line, called Slc41a3^{tm1a(KOMP)Wtsi [10] [11]} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. ^{[12] [13] [14]}

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. ^{[8] [15]} Twenty six tests were carried out on mutant mice and one significant abnormality was observed: homozygous mutants displayed abnormal locomotor coordination. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000114544 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030089 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Solute carrier family 41, member 3" . Retrieved 2011-09-28.
6. "Salmonella infection data for Slc41a3". Wellcome Trust Sanger Institute.
7. "Citrobacter infection data for Slc41a3". Wellcome Trust Sanger Institute.
8. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID   85911512.
9. Mouse Resources Portal, Wellcome Trust Sanger Institute.
10. "International Knockout Mouse Consortium".
11. "Mouse Genome Informatics".
12. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (June 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC   3572410 . PMID   21677750.
13. Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi: 10.1038/474262a . PMID   21677718.
14. Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi: 10.1016/j.cell.2006.12.018 . PMID   17218247. S2CID   18872015.
15. van der Weyden L, White JK, Adams DJ, Logan DW (June 2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC   3218837 . PMID   21722353.

Further reading

• Wabakken T, Rian E, Kveine M, Aasheim HC (July 2003). "The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters". Biochemical and Biophysical Research Communications. 306 (3): 718–24. doi:10.1016/S0006-291X(03)01030-1. PMID   12810078.