ATP8B3

ATP8B3
Identifiers
Aliases	ATP8B3 , ATPIK, ATPase phospholipid transporting 8B3
External IDs	OMIM: 605866; MGI: 1914581; HomoloGene: 19034; GeneCards: ATP8B3; OMA:ATP8B3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,812,276 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	80,374,958 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; buccal mucosa cell; ; stromal cell of endometrium; ; right adrenal gland; ; right adrenal cortex; ; granulocyte; ; testicle; ; left adrenal gland; ; left adrenal cortex;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; olfactory epithelium; ; embryo; ; facial motor nucleus; ; epiblast; ; islet of Langerhans; ; tail of embryo; ; anterior horn of spinal cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding ; metal ion binding ; ATPase-coupled intramembrane lipid transporter activity ; hydrolase activity ; ATP binding ; magnesium ion binding ;
Cellular component	integral component of membrane ; Golgi apparatus ; endoplasmic reticulum membrane ; membrane ; plasma membrane ; acrosomal membrane ; endoplasmic reticulum ; cytoplasmic vesicle ; acrosomal vesicle ;
Biological process	lipid transport ; Golgi organization ; phospholipid transport ; phospholipid translocation ; binding of sperm to zona pellucida ;
	Sources:Amigo / QuickGO
Orthologs
	148229
	67331
	ENSG00000130270
	ENSMUSG00000003341
	O60423
	Q6UQ17
	NM_001178002 ; NM_138813
	NM_026094
	NP_001171473 ; NP_620168
	NP_080370
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 08, 2025

The human gene ATP8B3 encodes the protein ATPase, aminophospholipid transporter, class I, type 8B, member 3.^[5]

Transcript

Alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[5]

Protein

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene encodes the member 3 of the phospholipid-transporting ATPase 8B.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000130270 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003341 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: ATPase, aminophospholipid transporter, class I, type 8B, member 3" . Retrieved 2011-10-22.

External links

Human ATP8B3 genome location and ATP8B3 gene details page in the UCSC Genome Browser .

Halleck MS, Lawler JF JR, Blackshaw S, Gao L, Nagarajan P, Hacker C, Pyle S, Newman JT, Nakanishi Y, Ando H, Weinstock D, Williamson P, Schlegel RA (November 1999). "Differential expression of putative transbilayer amphipath transporters". Physiological Genomics. 1 (3): 139–50. doi:10.1152/physiolgenomics.1999.1.3.139. PMID 11015572. S2CID 762447.
Harris MJ, Arias IM (July 2003). "FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1633 (2): 127–31. doi:10.1016/S1388-1981(03)00107-0. PMID 12880872.
Fries AS, Svendsen O (January 1978). "Studies on Tyzzer's disease in rats". Laboratory Animals. 12 (1): 1–4. doi:10.1258/002367778780953297. PMID 146761. S2CID 8184958.
Scott LJ, Muglia P, Kong XQ, Guan W, Flickinger M, Upmanyu R, Tozzi F, Li JZ, Burmeister M, Absher D, Thompson RC, Francks C, Meng F, Antoniades A, Southwick AM, Schatzberg AF, Bunney WE, Barchas JD, Jones EG, Day R, Matthews K, McGuffin P, Strauss JS, Kennedy JL, Middleton L, Roses AD, Watson SJ, Vincent JB, Myers RM, Farmer AE, Akil H, Burns DK, Boehnke M (May 2009). "Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry" (PDF). Proceedings of the National Academy of Sciences of the United States of America. 106 (18): 7501–6. Bibcode:2009PNAS..106.7501S. doi: 10.1073/pnas.0813386106 . PMC 2678639 . PMID 19416921.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000130270 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003341 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: ATPase, aminophospholipid transporter, class I, type 8B, member 3" . Retrieved 2011-10-22.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

ATP8B3

Contents

Transcript

Protein

References

External links

Further reading