ATP1B3

ATP1B3
Identifiers
Aliases	ATP1B3 , ATPB-3, CD298, ATPase Na+/K+ transporting subunit beta 3
External IDs	OMIM: 601867 MGI: 107788 HomoloGene: 37510 GeneCards: ATP1B3
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q23 Start 141,876,124 bp [1] End 141,926,549 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9 E3.3|9 50.31 cM Start 96,332,655 bp [2] End 96,364,442 bp [2]
Gene ontology Molecular function • ATPase binding • P-type sodium:potassium-exchanging transporter activity • ATPase activator activity Cellular component • cytoplasm • integral component of membrane • membrane • melanosome • cell membrane • sodium:potassium-exchanging ATPase complex • caveola • extracellular exosome Biological process • regulation of cardiac conduction • positive regulation of ATPase activity • positive regulation of sodium ion export across plasma membrane • sodium ion transport • cellular sodium ion homeostasis • sodium ion export across plasma membrane • metal ion transport • positive regulation of potassium ion import across plasma membrane • protein stabilization • ion transport • cellular potassium ion homeostasis • potassium ion transport • membrane repolarization • ion transmembrane transport • protein localization to plasma membrane • leukocyte migration • positive regulation of potassium ion transmembrane transporter activity • establishment or maintenance of transmembrane electrochemical gradient • transport • potassium ion import across plasma membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	483	11933
Ensembl	ENSG00000069849	ENSMUSG00000032412
UniProt	P54709	P97370
RefSeq (mRNA)	NM_001679	NM_007502 NM_001357212 NM_001357213
RefSeq (protein)	NP_001670	NP_031528 NP_001344141 NP_001344142
Location (UCSC)	Chr 3: 141.88 – 141.93 Mb	Chr 9: 96.33 – 96.36 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Sodium/potassium-transporting ATPase subunit beta-3 is an enzyme that in humans is encoded by the ATP1B3 gene. ^{[5] [6] [7]} ATP1B3 has also been designated as CD298 (cluster of differentiation 298).

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000069849 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032412 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Malik N, Canfield VA, Beckers MC, Gros P, Levenson R (Nov 1996). "Identification of the mammalian Na,K-ATPase 3 subunit". J Biol Chem. 271 (37): 22754–8. doi: 10.1074/jbc.271.37.22754 . PMID   8798450.
6. Malik N, Canfield V, Sanchez-Watts G, Watts AG, Scherer S, Beatty BG, Gros P, Levenson R (Mar 1998). "Structural organization and chromosomal localization of the human Na,K-ATPase beta 3 subunit gene and pseudogene". Mamm Genome. 9 (2): 136–43. doi:10.1007/s003359900704. PMID   9457675. S2CID   31228553.
7. "Entrez Gene: ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide".

Further reading

• Lingrel JB, Orlowski J, Shull MM, Price EM (1990). "Molecular genetics of Na,K-ATPase". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 38: 37–89. doi:10.1016/S0079-6603(08)60708-4. ISBN   978-0-12-540038-1. PMID   2158121.
• Jørgensen PL (1982). "Mechanism of the Na+, K+ pump. Protein structure and conformations of the pure (Na+ +K+)-ATPase". Biochim. Biophys. Acta. 694 (1): 27–68. doi:10.1016/0304-4157(82)90013-2. PMID   6289898.
• Chiampanichayakul S, Szekeres A, Khunkaewla P, et al. (2003). "Engagement of Na,K-ATPase beta3 subunit by a specific mAb suppresses T and B lymphocyte activation". Int. Immunol. 14 (12): 1407–14. doi: 10.1093/intimm/dxf112 . PMID   12456588.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID   12754519. S2CID   581283.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID   17081065.
• Chiampanichayakul S, Khunkaewla P, Pata S, Kasinrerk W (2007). "Na, K ATPase beta3 subunit (CD298): association with alpha subunit and expression on peripheral blood cells". Tissue Antigens. 68 (6): 509–17. doi:10.1111/j.1399-0039.2006.00726.x. PMID   17176442.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Aughey RJ, Murphy KT, Clark SA, et al. (2007). "Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes". J. Appl. Physiol. 103 (1): 39–47. doi:10.1152/japplphysiol.00236.2006. PMID   17446412.

External links

• ATP1B3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human ATP1B3 genome location and ATP1B3 gene details page in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.