ATP1B3

Last updated
ATP1B3
Identifiers
Aliases ATP1B3 , ATPB-3, CD298, ATPase Na+/K+ transporting subunit beta 3
External IDs OMIM: 601867 MGI: 107788 HomoloGene: 37510 GeneCards: ATP1B3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001679

NM_007502
NM_001357212
NM_001357213

RefSeq (protein)

NP_001670

NP_031528
NP_001344141
NP_001344142

Location (UCSC) Chr 3: 141.88 – 141.93 Mb Chr 9: 96.33 – 96.36 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sodium/potassium-transporting ATPase subunit beta-3 is an enzyme that in humans is encoded by the ATP1B3 gene. [5] [6] [7] ATP1B3 has also been designated as CD298 (cluster of differentiation 298).

Contents

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [7]

Related Research Articles

ATPase, Na<sup>+</sup>/K<sup>+</sup> transporting, alpha 1

Sodium/potassium-transporting ATPase subunit alpha-1 is an enzyme that in humans is encoded by the ATP1A1 gene.

ATP1A2

ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide, also known as ATP1A2, is a protein which in humans is encoded by the ATP1A2 gene.

ATP6V1E1

V-type proton ATPase subunit E 1 is an enzyme that in humans is encoded by the ATP6V1E1 gene.

ATP1B1

Sodium/potassium-transporting ATPase subunit beta-1 is an enzyme that in humans is encoded by the ATP1B1 gene.

ATP1A3

Sodium/potassium-transporting ATPase subunit alpha-3 is an enzyme that in humans is encoded by the ATP1A3 gene.

ATP6V1B2

V-type proton ATPase subunit B, brain isoform is an enzyme that in humans is encoded by the ATP6V1B2 gene.

ATPase, H+ transporting, lysosomal V0 subunit a1

V-type proton ATPase 116 kDa subunit a isoform 1 is an enzyme that in humans is encoded by the ATP6V0A1 gene.

ATP1A4

Sodium/potassium-transporting ATPase subunit alpha-4 is an enzyme that in humans is encoded by the ATP1A4 gene.

ATP6V1A

V-type proton ATPase catalytic subunit A is an enzyme that in humans is encoded by the ATP6V1A gene.

ATP6V0D1

V-type proton ATPase subunit d 1 is an enzyme that in humans is encoded by the ATP6V0D1 gene.

ATP6V1D

V-type proton ATPase subunit D is an enzyme that in humans is encoded by the ATP6V1D gene.

ATP6V1F

V-type proton ATPase subunit F is an enzyme that in humans is encoded by the ATP6V1F gene.

ATP12A

ATPase, H+/K+ transporting, nongastric, alpha polypeptide is a protein that in humans is encoded by the ATP12A gene.

ATP6V0B Protein-coding gene in Homo sapiens

V-type proton ATPase 21 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0B gene.

ATP5L

ATP synthase subunit g, mitochondrial is an enzyme that in humans is encoded by the ATP5MG gene.

ATP5C1

The human ATP5F1C gene encodes the gamma subunit of an enzyme called mitochondrial ATP synthase.

ATP5F1

ATP synthase subunit b, mitochondrial is an enzyme that in humans is encoded by the ATP5PB gene.

ATP6V0A2

V-type proton ATPase 116 kDa subunit a isoform 2 also known as V-ATPase 116 kDa isoform a2 is an enzyme that in humans is encoded by the ATP6V0A2 gene.

ATP5G2

The ATP5MC2 gene is one of three human paralogs that encode membrane subunit c of the mitochondrial ATP synthase.

ATP5H

The human gene ATP5PD encodes subunit d of the peripheral stalk part of the enzyme mitochondrial ATP synthase.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000069849 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032412 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Malik N, Canfield VA, Beckers MC, Gros P, Levenson R (Nov 1996). "Identification of the mammalian Na,K-ATPase 3 subunit". J Biol Chem. 271 (37): 22754–8. doi: 10.1074/jbc.271.37.22754 . PMID   8798450.
  6. Malik N, Canfield V, Sanchez-Watts G, Watts AG, Scherer S, Beatty BG, Gros P, Levenson R (Mar 1998). "Structural organization and chromosomal localization of the human Na,K-ATPase beta 3 subunit gene and pseudogene". Mamm Genome. 9 (2): 136–43. doi:10.1007/s003359900704. PMID   9457675. S2CID   31228553.
  7. 1 2 "Entrez Gene: ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.