Rnd1

RND1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CLS, 2REX, 3Q3J
Identifiers
Aliases	RND1 , ARHS, RHO6, RHOS, Rnd1, Rho family GTPase 1
External IDs	OMIM: 609038; MGI: 2444878; HomoloGene: 8706; GeneCards: RND1; OMA:RND1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.12 Start 48,857,145 bp [1] End 48,865,870 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 F1 Start 98,561,302 bp [2] End 98,575,342 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava right lobe of liver frontal pole prefrontal cortex right frontal lobe middle temporal gyrus dorsolateral prefrontal cortex primary visual cortex Brodmann area 9 cingulate gyrus Top expressed in lumbar subsegment of spinal cord granulocyte primary visual cortex morula ventricular zone cerebellar cortex superior frontal gyrus endothelial cell of lymphatic vessel neural layer of retina dorsomedial hypothalamic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding signaling receptor binding protein binding GTPase activity protein kinase binding Cellular component cytoplasm adherens junction cytosol cytoskeleton membrane plasma membrane actin cytoskeleton intracellular membrane-bounded organelle intracellular anatomical structure cell cortex cell division site Biological process neuron remodeling small GTPase mediated signal transduction negative regulation of cell adhesion actin filament organization Rho protein signal transduction regulation of cell shape regulation of cell migration establishment or maintenance of actin cytoskeleton polarity regulation of actin cytoskeleton organization actin filament bundle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27289 223881 Ensembl ENSG00000172602 ENSMUSG00000054855 UniProt Q92730 Q8BLR7 RefSeq (mRNA) NM_014470 NM_172612 RefSeq (protein) NP_055285 NP_766200 Location (UCSC) Chr 12: 48.86 – 48.87 Mb Chr 15: 98.56 – 98.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rnd1 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases. ^[5] It is encoded by the gene RND1. ^[6]

It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM] ^[6]

Interactions

Rnd1 has been shown to interact with GRB7, ^[7] PLXNB1, ^[8] PDE6D, ^{[9] [10]} ARHGAP5 ^[11] and UBXD5. ^[12]

References

1. GRCh38: Ensembl release 89: ENSG00000172602 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054855 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ridley AJ (Oct 2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends in Cell Biology. 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. PMID   16949823.
6. "Entrez Gene: RND1 Rho family GTPase 1".
7. Vayssière B, Zalcman G, Mahé Y, Mirey G, Ligensa T, Weidner KM, Chardin P, Camonis J (Feb 2000). "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family". FEBS Letters. 467 (1): 91–6. doi: 10.1016/S0014-5793(99)01530-6 . PMID   10664463. S2CID   4901644.
8. Oinuma I, Katoh H, Harada A, Negishi M (Jul 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". The Journal of Biological Chemistry. 278 (28): 25671–7. doi: 10.1074/jbc.M303047200 . PMID   12730235.
9. Nancy V, Callebaut I, El Marjou A, de Gunzburg J (Apr 2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". The Journal of Biological Chemistry. 277 (17): 15076–84. doi: 10.1074/jbc.M109983200 . PMID   11786539.
10. Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (May 2002). "The complex of Arl2-GTP and PDE delta: from structure to function". The EMBO Journal. 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMC   125981 . PMID   11980706.
11. Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH (Jul 2003). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Current Biology. 13 (13): 1106–15. Bibcode:2003CBio...13.1106W. doi:10.1016/S0960-9822(03)00418-4. PMC   6918695 . PMID   12842009.
12. Katoh H, Harada A, Mori K, Negishi M (May 2002). "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers". Molecular and Cellular Biology. 22 (9): 2952–64. doi:10.1128/MCB.22.9.2952-2964.2002. PMC   133765 . PMID   11940653.

Further reading

• Nobes CD, Lauritzen I, Mattei MG, Paris S, Hall A, Chardin P (Apr 1998). "A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion". The Journal of Cell Biology. 141 (1): 187–97. doi:10.1083/jcb.141.1.187. PMC   2132722 . PMID   9531558.
• Vayssière B, Zalcman G, Mahé Y, Mirey G, Ligensa T, Weidner KM, Chardin P, Camonis J (Feb 2000). "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family". FEBS Letters. 467 (1): 91–6. doi: 10.1016/S0014-5793(99)01530-6 . PMID   10664463. S2CID   4901644.
• Aoki J, Katoh H, Mori K, Negishi M (Nov 2000). "Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells". Biochemical and Biophysical Research Communications. 278 (3): 604–8. doi:10.1006/bbrc.2000.3842. PMID   11095956.
• Rohm B, Rahim B, Kleiber B, Hovatta I, Püschel AW (Dec 2000). "The semaphorin 3A receptor may directly regulate the activity of small GTPases". FEBS Letters. 486 (1): 68–72. doi: 10.1016/S0014-5793(00)02240-7 . PMID   11108845. S2CID   7914214.
• Nancy V, Callebaut I, El Marjou A, de Gunzburg J (Apr 2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". The Journal of Biological Chemistry. 277 (17): 15076–84. doi: 10.1074/jbc.M109983200 . PMID   11786539.
• Katoh H, Harada A, Mori K, Negishi M (May 2002). "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers". Molecular and Cellular Biology. 22 (9): 2952–64. doi:10.1128/MCB.22.9.2952-2964.2002. PMC   133765 . PMID   11940653.
• Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (May 2002). "The complex of Arl2-GTP and PDE delta: from structure to function". The EMBO Journal. 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMC   125981 . PMID   11980706.
• Oinuma I, Katoh H, Harada A, Negishi M (Jul 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". The Journal of Biological Chemistry. 278 (28): 25671–7. doi: 10.1074/jbc.M303047200 . PMID   12730235.
• Oinuma I, Ishikawa Y, Katoh H, Negishi M (Aug 2004). "The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras". Science. 305 (5685): 862–5. Bibcode:2004Sci...305..862O. doi:10.1126/science.1097545. PMID   15297673. S2CID   39544623.
• Harada A, Katoh H, Negishi M (May 2005). "Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells". The Journal of Biological Chemistry. 280 (18): 18418–24. doi: 10.1074/jbc.M411356200 . PMID   15738000.
• Kim YS, Hori M, Yasuda K, Ozaki H (Dec 2005). "Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria". Comparative Biochemistry and Physiology A. 142 (4): 410–5. doi:10.1016/j.cbpa.2005.08.028. PMID   16311049.