Guanine nucleotide-binding protein subunit alpha-13 is a protein that in humans is encoded by the GNA13 gene. [5] [6]
Guanine nucleotide-binding protein subunit alpha-13 is a protein that in humans is encoded by the GNA13 gene. [5] [6]
The GNA13 gene encodes the G13 G protein alpha subunit. Together with GNA12, these two proteins comprise one of the four classes of heterotrimeric G protein alpha subunits. [7] Heterotrimeric G proteins function in transducing hormone and neurotransmitter signals detected by cell surface G protein-coupled receptors to intracellular signaling pathways to modulate cell functions. G protein alpha subunits bind to guanine nucleotides and function in a regulatory cycle, and are active when bound to GTP but inactive and associated with the G beta-gamma complex when bound to GDP. [8] [9]
Active GTP-bound G12 alpha subunit interacts with and activates ARHGEF1, [10] [11] [12] ARHGEF11, [13] [14] and ARHGEF12. [15] [16] These ARHGEF proteins function as guanine nucleotide exchange factors for the Rho small GTPases to regulate the actin cytoskeleton. [17]
GNA13 has been shown to interact with AKAP3, [18] RIC8A, [19] [20] and Radixin. [21]
Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma. [22] [23]
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
