GNAI3

GNAI3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IHB, 2ODE, 2V4Z, 4G5O, 4G5R, 4G5S
Identifiers
Aliases	GNAI3 , 87U6, ARCND1, G protein subunit alpha i3, HG1A
External IDs	OMIM: 139370 MGI: 95773 HomoloGene: 55975 GeneCards: GNAI3
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.3 Start 109,548,615 bp [1] End 109,600,195 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 F2.3|3 46.83 cM Start 108,014,596 bp [2] End 108,053,462 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parietal pleura visceral pleura hair follicle tibia cavity of mouth cervix epithelium palpebral conjunctiva vulva secondary oocyte amniotic fluid Top expressed in abdominal wall medial ganglionic eminence dermis primitive streak vas deferens seminal vesicula epidermis calvaria maxillary prominence skin of abdomen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity metal ion binding protein domain specific binding nucleotide binding GTPase activating protein binding guanyl nucleotide binding GDP binding G protein-coupled receptor binding G-protein beta/gamma-subunit complex binding G protein-coupled serotonin receptor binding protein binding GTPase activity GTP binding Cellular component extracellular exosome lysosomal membrane cytoplasm microtubule organizing center Golgi apparatus heterotrimeric G-protein complex membrane centrosome midbody membrane raft zymogen granule cytoskeleton plasma membrane nucleus nucleolus Golgi membrane endoplasmic reticulum membrane Biological process cell cycle signal transduction negative regulation of adenylate cyclase activity GTP metabolic process cell division vesicle fusion dopamine receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway protein folding adenylate cyclase-modulating G protein-coupled receptor signaling pathway transport positive regulation of macroautophagy G protein-coupled receptor signaling pathway brain development positive regulation of superoxide anion generation positive regulation of NAD(P)H oxidase activity positive regulation of vascular associated smooth muscle cell proliferation negative regulation of apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2773 14679 Ensembl ENSG00000065135 ENSMUSG00000000001 UniProt P08754 Q9DC51 RefSeq (mRNA) NM_006496 NM_010306 RefSeq (protein) NP_006487 NP_034436 Location (UCSC) Chr 1: 109.55 – 109.6 Mb Chr 3: 108.01 – 108.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Guanine nucleotide-binding protein G(k) subunit alpha is a protein that in humans is encoded by the GNAI3 gene. ^{[5] [6]}

Interactions

GNAI3 has been shown to interact with:

• RGS10 ^[7]
• RGS12, ^[8]
• RGS14, ^[8]
• RGS16, ^{[9] [10]}
• RGS18, ^{[11] [12]}
• RGS19, ^{[13] [14] [15]}
• RGS5, ^{[9] [16]}
• RIC8A, ^[17] and
• S1PR1. ^[18]

See also

• Gi alpha subunit

References

1. GRCh38: Ensembl release 89: ENSG00000065135 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000001 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Didsbury JR, Snyderman R (Jul 1987). "Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families". FEBS Letters. 219 (1): 259–63. doi:10.1016/0014-5793(87)81228-0. PMID   3109953. S2CID   85219415.
6. "Entrez Gene: GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3".
7. Hunt TW, Fields TA, Casey PJ, Peralta EG (Sep 1996). "RGS10 is a selective activator of G alpha i GTPase activity". Nature. 383 (6596): 175–7. Bibcode:1996Natur.383..175H. doi:10.1038/383175a0. PMID   8774883. S2CID   4318445.
8. Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP (Aug 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". The Journal of Biological Chemistry. 276 (31): 29275–81. doi: 10.1074/jbc.M103208200 . PMID   11387333.
9. Chen C, Zheng B, Han J, Lin SC (Mar 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". The Journal of Biological Chemistry. 272 (13): 8679–85. doi: 10.1074/jbc.272.13.8679 . PMID   9079700.
10. Beadling C, Druey KM, Richter G, Kehrl JH, Smith KA (Mar 1999). "Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes". Journal of Immunology. 162 (5): 2677–82. doi:10.4049/jimmunol.162.5.2677. PMID   10072511.
11. Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie TM, Gutierrez-Ramos C, Hodge MR (Oct 2001). "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". The Biochemical Journal. 359 (Pt 1): 109–18. doi:10.1042/bj3590109. PMC   1222126 . PMID   11563974.
12. Gagnon AW, Murray DL, Leadley RJ (Jul 2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cellular Signalling. 14 (7): 595–606. doi:10.1016/s0898-6568(02)00012-8. PMID   11955952.
13. De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proceedings of the National Academy of Sciences of the United States of America. 93 (26): 15203–8. Bibcode:1996PNAS...9315203D. doi: 10.1073/pnas.93.26.15203 . PMC   26381 . PMID   8986788.
14. Woulfe DS, Stadel JM (Jun 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". The Journal of Biological Chemistry. 274 (25): 17718–24. doi: 10.1074/jbc.274.25.17718 . PMID   10364213.
15. De Vries L, Mousli M, Wurmser A, Farquhar MG (Dec 1995). "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain". Proceedings of the National Academy of Sciences of the United States of America. 92 (25): 11916–20. Bibcode:1995PNAS...9211916D. doi: 10.1073/pnas.92.25.11916 . PMC   40514 . PMID   8524874.
16. Zhou J, Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S (Feb 2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sciences. 68 (13): 1457–69. doi:10.1016/s0024-3205(01)00939-0. PMID   11253162.
17. Tall GG, Krumins AM, Gilman AG (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". The Journal of Biological Chemistry. 278 (10): 8356–62. doi: 10.1074/jbc.M211862200 . PMID   12509430.
18. Lee MJ, Evans M, Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". The Journal of Biological Chemistry. 271 (19): 11272–9. doi: 10.1074/jbc.271.19.11272 . PMID   8626678.

Further reading

• Downes GB, Gautam N (Dec 1999). "The G protein subunit gene families". Genomics. 62 (3): 544–52. doi:10.1006/geno.1999.5992. PMID   10644457.
• Sidhu A, Niznik HB (Nov 2000). "Coupling of dopamine receptor subtypes to multiple and diverse G proteins". International Journal of Developmental Neuroscience. 18 (7): 669–77. doi:10.1016/S0736-5748(00)00033-2. PMID   10978845. S2CID   21002590.
• Jiang M, Pandey S, Tran VT, Fong HK (May 1991). "Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells". Proceedings of the National Academy of Sciences of the United States of America. 88 (9): 3907–11. Bibcode:1991PNAS...88.3907J. doi: 10.1073/pnas.88.9.3907 . PMC   51562 . PMID   1902575.
• Carty DJ, Padrell E, Codina J, Birnbaumer L, Hildebrandt JD, Iyengar R (Apr 1990). "Distinct guanine nucleotide binding and release properties of the three Gi proteins". The Journal of Biological Chemistry. 265 (11): 6268–73. doi: 10.1016/S0021-9258(19)39320-2 . PMID   2108158.
• Suki WN, Abramowitz J, Mattera R, Codina J, Birnbaumer L (Aug 1987). "The human genome encodes at least three non-allellic G proteins with alpha i-type subunits". FEBS Letters. 220 (1): 187–92. doi: 10.1016/0014-5793(87)80900-6 . PMID   2440724. S2CID   83824512.
• Codina J, Olate J, Abramowitz J, Mattera R, Cook RG, Birnbaumer L (May 1988). "Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channels". The Journal of Biological Chemistry. 263 (14): 6746–50. doi: 10.1016/S0021-9258(18)68706-X . PMID   2452165.
• Itoh H, Toyama R, Kozasa T, Tsukamoto T, Matsuoka M, Kaziro Y (May 1988). "Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs". The Journal of Biological Chemistry. 263 (14): 6656–64. doi: 10.1016/S0021-9258(18)68692-2 . PMID   2834384.
• Beals CR, Wilson CB, Perlmutter RM (Nov 1987). "A small multigene family encodes Gi signal-transduction proteins". Proceedings of the National Academy of Sciences of the United States of America. 84 (22): 7886–90. Bibcode:1987PNAS...84.7886B. doi: 10.1073/pnas.84.22.7886 . PMC   299440 . PMID   3120178.
• Kim SY, Ang SL, Bloch DB, Bloch KD, Kawahara Y, Tolman C, Lee R, Seidman JG, Neer EJ (Jun 1988). "Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines". Proceedings of the National Academy of Sciences of the United States of America. 85 (12): 4153–7. Bibcode:1988PNAS...85.4153K. doi: 10.1073/pnas.85.12.4153 . PMC   280384 . PMID   3132707.
• Migeon JC, Thomas SL, Nathanson NM (Jul 1995). "Differential coupling of m2 and m4 muscarinic receptors to inhibition of adenylyl cyclase by Gi alpha and G(o)alpha subunits". The Journal of Biological Chemistry. 270 (27): 16070–4. doi: 10.1074/jbc.270.27.16070 . PMID   7608168.
• Raymond JR, Olsen CL, Gettys TW (Oct 1993). "Cell-specific physical and functional coupling of human 5-HT1A receptors to inhibitory G protein alpha-subunits and lack of coupling to Gs alpha". Biochemistry. 32 (41): 11064–73. doi:10.1021/bi00092a016. PMID   8218170.
• Wu D, LaRosa GJ, Simon MI (Jul 1993). "G protein-coupled signal transduction pathways for interleukin-8". Science. 261 (5117): 101–3. Bibcode:1993Sci...261..101W. doi:10.1126/science.8316840. PMID   8316840.
• Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A (Jun 1993). "Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy". Endocrinology. 132 (6): 2484–90. doi:10.1210/endo.132.6.8504751. PMID   8504751.
• De Vries L, Mousli M, Wurmser A, Farquhar MG (Dec 1995). "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain". Proceedings of the National Academy of Sciences of the United States of America. 92 (25): 11916–20. Bibcode:1995PNAS...9211916D. doi: 10.1073/pnas.92.25.11916 . PMC   40514 . PMID   8524874.
• Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE, Schultz G (Jan 1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families". Proceedings of the National Academy of Sciences of the United States of America. 93 (1): 116–20. Bibcode:1996PNAS...93..116L. doi: 10.1073/pnas.93.1.116 . PMC   40189 . PMID   8552586.
• Lee MJ, Evans M, Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". The Journal of Biological Chemistry. 271 (19): 11272–9. doi: 10.1074/jbc.271.19.11272 . PMID   8626678.
• Solomon KR, Rudd CE, Finberg RW (Jun 1996). "The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes". Proceedings of the National Academy of Sciences of the United States of America. 93 (12): 6053–8. Bibcode:1996PNAS...93.6053S. doi: 10.1073/pnas.93.12.6053 . PMC   39187 . PMID   8650218.
• Zhang J, Pratt RE (Jun 1996). "The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetus". The Journal of Biological Chemistry. 271 (25): 15026–33. doi: 10.1074/jbc.271.25.15026 . PMID   8663053.
• Hunt TW, Fields TA, Casey PJ, Peralta EG (Sep 1996). "RGS10 is a selective activator of G alpha i GTPase activity". Nature. 383 (6596): 175–7. Bibcode:1996Natur.383..175H. doi:10.1038/383175a0. PMID   8774883. S2CID   4318445.