GNG5

GNG5
Identifiers
Aliases	GNG5 , G protein subunit gamma 5
External IDs	OMIM: 600874; MGI: 3783217; HomoloGene: 3861; GeneCards: GNG5; OMA:GNG5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p22.3 Start 84,498,323 bp [1] End 84,506,581 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon left ventricle right auricle of heart apex of heart muscle of thigh right lung ventricular zone upper lobe of left lung olfactory zone of nasal mucosa granulocyte n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding protein binding GTPase activity signal transducer activity G-protein beta-subunit binding Cellular component extracellular exosome mitochondrion membrane heterotrimeric G-protein complex plasma membrane G-protein beta/gamma-subunit complex Biological process positive regulation of neural precursor cell proliferation positive regulation of secondary heart field cardioblast proliferation cellular response to glucagon stimulus signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2787 100043507 Ensembl ENSG00000174021 n/a UniProt P63218 Q80SZ7 RefSeq (mRNA) NM_005274 n/a RefSeq (protein) NP_005265 NP_034448 Location (UCSC) Chr 1: 84.5 – 84.51 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 is a protein that in humans is encoded by the GNG5 gene. ^{[4] [5]}

References

1. GRCh38: Ensembl release 89: ENSG00000174021 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Ahmad W, Li S, Chen H, Tuck-Muller CM, Pittler SJ, Aronson NN Jr (Aug 1995). "Lysosomal chitobiase (CTB) and the G-protein gamma 5 subunit (GNG5) genes co-localize to human chromosome 1p22". Cytogenet Cell Genet. 71 (1): 44–6. doi:10.1159/000134059. PMID   7606925.
5. "Entrez Gene: GNG5 guanine nucleotide binding protein (G protein), gamma 5".

Further reading

• Fisher KJ, Aronson NN (1992). "Characterization of the cDNA and genomic sequence of a G protein gamma subunit (gamma 5)". Mol. Cell. Biol. 12 (4): 1585–91. doi:10.1128/mcb.12.4.1585. PMC   369601 . PMID   1549114.
• Yan K, Kalyanaraman V, Gautam N (1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi: 10.1074/jbc.271.12.7141 . PMID   8636150.
• Mao M, Fu G, Wu JS, et al. (1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi: 10.1073/pnas.95.14.8175 . PMC   20949 . PMID   9653160.
• Liu B, Aronson NN (1998). "Structure of human G protein G gamma 5 gene GNG5". Biochem. Biophys. Res. Commun. 251 (1): 88–94. doi:10.1006/bbrc.1998.9439. PMID   9790912.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Cuello F, Schulze RA, Heemeyer F, et al. (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi: 10.1074/jbc.M210304200 . PMID   12486123.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.