IRAK3

Last updated
IRAK3
Identifiers
Aliases IRAK3 , ASRT5, IRAKM, interleukin 1 receptor associated kinase 3
External IDs OMIM: 604459; MGI: 1921164; HomoloGene: 36215; GeneCards: IRAK3; OMA:IRAK3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007199
NM_001142523

NM_028679
NM_001359184

RefSeq (protein)

NP_001135995
NP_009130

NP_082955
NP_001346113

Location (UCSC) Chr 12: 66.19 – 66.25 Mb Chr 10: 119.98 – 120.04 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin-1 receptor-associated kinase 3 is an enzyme that in humans is encoded by the IRAK3 gene. [5] [6] Using in vivo liposome-mediated delivery of CRISPR/Cas9 plasmid expressing IRAK3 gRNA, IRAK3 was shown to be responsible for endotoxin-induced expression of A20 and VE-cadherin in endothelial cells. Thus, IRAK3 is crucial for maintenance and repair of endothelial barrier after endotoxin-induced lung injury. [7]

Contents

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000090376 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020227 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (July 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry. 274 (27): 19403–10. doi: 10.1074/jbc.274.27.19403 . PMID   10383454.
  6. "Entrez Gene: IRAK3 interleukin-1 receptor-associated kinase 3".
  7. Soni D, Wang DM, Regmi SC, Mittal M, Vogel SM, Schlüter D, Tiruppathi C (May 2018). "Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury". Cell Death Discovery. 4 (60) 60. doi:10.1038/s41420-018-0056-3. PMC   5955943 . PMID   29796309.

Further reading