PRKY

PRKY
Identifiers
Aliases	PRKY , PRKXP3, PRKYP, protein kinase, Y-linked, pseudogene, protein kinase Y-linked (pseudogene)
External IDs	OMIM: 400008; GeneCards: PRKY; OMA:PRKY - orthologs
Gene location (Human) Chr. Y chromosome (human) [1] Band Yp11.2 Start 7,273,972 bp [1] End 7,381,548 bp [1]
Orthologs Species Human Mouse Entrez 5616 n/a Ensembl ENSG00000099725 n/a UniProt n a n/a RefSeq (mRNA) NM_002760 n/a RefSeq (protein) n/a n/a Location (UCSC) Chr Y: 7.27 – 7.38 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Serine/threonine-protein kinase PRKY is an enzyme that in humans is encoded by the PRKY gene. ^{[3] [4]}

This gene encodes a member of the cAMP-dependent serine/threonine protein kinase family. This gene is located on chromosome Y, near the boundary of the pseudoautosomal region. Abnormal recombination between this gene and a related gene on chromosome X is a frequent cause of XX males and XY females. ^[4]

References

1. GRCh38: Ensembl release 89: ENSG00000099725 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Klink A, Schiebel K, Winkelmann M, Rao E, Horsthemke B, Ludecke HJ, Claussen U, Scherer G, Rappold G (Sep 1995). "The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability". Hum Mol Genet. 4 (5): 869–78. doi:10.1093/hmg/4.5.869. PMID   7633447.
4. "Entrez Gene: PRKY protein kinase, Y-linked".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. Bibcode:2003Natur.423..825S. doi: 10.1038/nature01722 . PMID   12815422.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Jobling MA, Williams GA, Schiebel GA, et al. (1999). "A selective difference between human Y-chromosomal DNA haplotypes". Curr. Biol. 8 (25): 1391–4. doi: 10.1016/S0960-9822(98)00020-7 . PMID   9889101.
• Schiebel K, Winkelmann M, Mertz A, et al. (1998). "Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females". Hum. Mol. Genet. 6 (11): 1985–9. doi: 10.1093/hmg/6.11.1985 . PMID   9302280.
• Schiebel K, Mertz A, Winkelmann M, et al. (1997). "FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12→q13". Cytogenet. Cell Genet. 76 (1–2): 49–52. doi:10.1159/000134514. PMID   9154127.
• Gläser B, Hierl T, Taylor K, et al. (1997). "High-resolution fluorescence in situ hybridization of human Y-linked genes on released chromatin". Chromosome Res. 5 (1): 23–30. doi:10.1023/A:1018437301461. PMID   9088640. S2CID   31543330.