SGK2

SGK2
Identifiers
Aliases	SGK2 , H-dJ138B7.2, serine/threonine kinase 2, serum/glucocorticoid regulated kinase 2
External IDs	OMIM: 607589; MGI: 1351318; HomoloGene: 8446; GeneCards: SGK2; OMA:SGK2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.12 Start 43,558,968 bp [1] End 43,588,237 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H2 Start 162,829,250 bp [2] End 162,856,047 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right lobe of liver rectum human kidney C1 segment renal medulla duodenum body of pancreas kidney tubule mucosa of ileum Top expressed in right kidney human kidney left lobe of liver proximal tubule pyloric antrum mucous cell of stomach epithelium of stomach large intestine ileum intestinal villus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATP binding calcium channel regulator activity sodium channel regulator activity protein kinase activity potassium channel regulator activity kinase activity chloride channel regulator activity nucleotide binding transferase activity protein serine/threonine kinase activity Cellular component nucleus intracellular anatomical structure cytosol cytoplasm nucleoplasm cellular component Biological process response to oxidative stress positive regulation of transporter activity regulation of cell population proliferation ion transmembrane transport protein phosphorylation intracellular signal transduction peptidyl-serine phosphorylation regulation of apoptotic process phosphorylation regulation of cell growth Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10110 27219 Ensembl ENSG00000101049 ENSMUSG00000017868 UniProt Q9HBY8 Q5H8Y5 Q9QZS5 RefSeq (mRNA) NM_170693 NM_001199264 NM_016276 NM_001291152 NM_001291154 NM_013731 RefSeq (protein) NP_001186193 NP_057360 NP_733794 NP_001278081 NP_001278083 NP_038759 Location (UCSC) Chr 20: 43.56 – 43.59 Mb Chr 2: 162.83 – 162.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase Sgk2 is an enzyme that in humans is encoded by the SGK2 gene. ^{[5] [6]}

This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase (PI3K), which is also true for SGK. Two alternate transcripts encoding two different isoforms have been described. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000101049 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000017868 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kobayashi T, Deak M, Morrice N, Cohen P (Jan 2000). "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase". Biochem J. 344 (1): 189–97. doi:10.1042/0264-6021:3440189. PMC   1220630 . PMID   10548550.
6. "Entrez Gene: SGK2 serum/glucocorticoid regulated kinase 2".

Further reading

• Lang F, Cohen P (2002). "Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms". Sci. STKE. 2001 (108): RE17. doi:10.1126/stke.2001.108.re17. PMID   11707620. S2CID   25927734.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Gamper N, Fillon S, Feng Y, et al. (2003). "K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK". Pflügers Arch. 445 (1): 60–6. doi:10.1007/s00424-002-0873-2. PMID   12397388. S2CID   21073737.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Friedrich B, Feng Y, Cohen P, et al. (2003). "The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC". Pflügers Arch. 445 (6): 693–6. doi:10.1007/s00424-002-0993-8. PMID   12632189. S2CID   32511608.
• Embark HM, Böhmer C, Vallon V, et al. (2003). "Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms". Pflügers Arch. 445 (5): 601–6. doi:10.1007/s00424-002-0982-y. PMID   12634932. S2CID   22981271.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Baltaev R, Strutz-Seebohm N, Korniychuk G, et al. (2005). "Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes". Pflügers Arch. 450 (1): 26–33. doi:10.1007/s00424-004-1369-z. PMID   15578212. S2CID   190895.
• Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID   15790807. S2CID   13047538.

External links

• SGK2 human gene location in the UCSC Genome Browser .
• SGK2 human gene details in the UCSC Genome Browser .