ZAK

Last updated

MAP3K20
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MAP3K20 , AZK, MLK7, MLT, MLTK, MRK, mlklak, pk, ZAK, SFMMP, sterile alpha motif and leucine zipper containing kinase AZK, mitogen-activated protein kinase kinase kinase 20, MLTKalpha, MLTKbeta, CNM6
External IDs OMIM: 609479; MGI: 2443258; HomoloGene: 32331; GeneCards: MAP3K20; OMA:MAP3K20 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016653
NM_133646

NM_001164791
NM_023057
NM_178084

RefSeq (protein)

NP_057737
NP_598407

NP_001158263
NP_075544
NP_835185

Location (UCSC) Chr 2: 173.08 – 173.27 Mb Chr 2: 72.12 – 72.27 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sterile alpha motif and leucine zipper containing kinase AZK, also known as ZAK, is a human gene. [5]

Contents

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [5] [6]

Interactions

ZAK has been shown to interact with ZNF33A. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000091436 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004085 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: ZAK sterile alpha motif and leucine zipper containing kinase AZK".
  6. Liu TC, Huang CJ, Chu YC, Wei CC, Chou CC, Chou MY, et al. (11 August 2000). "Cloning and Expression of ZAK, a Mixed Lineage Kinase-like Protein Containing a Leucine-Zipper and a Sterile-Alpha Motif". Biochemical and Biophysical Research Communications. 274 (3): 811–816. Bibcode:2000BBRC..274..811L. doi:10.1006/bbrc.2000.3236. PMID   10924358.
  7. Yang JJ (Jan 2003). "A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle". Biochemical and Biophysical Research Communications. 301 (1): 71–77. Bibcode:2003BBRC..301...71Y. doi:10.1016/S0006-291X(02)02980-7. ISSN   0006-291X. PMID   12535642.

Further reading