KIAA0999

SIK3
Identifiers
Aliases	SIK3 , QSK, SIK-3, L19, KIAA0999, SIK family kinase 3, SEMDK
External IDs	OMIM: 614776; MGI: 2446296; HomoloGene: 57023; GeneCards: SIK3; OMA:SIK3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q23.3 Start 116,843,402 bp [1] End 117,098,437 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 A5.2 Start 45,924,118 bp [2] End 46,135,492 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus corpus callosum lateral nuclear group of thalamus pars reticulata sperm pars compacta inferior ganglion of vagus nerve ventral tegmental area middle frontal gyrus subthalamic nucleus Top expressed in substantia nigra lumbar subsegment of spinal cord medial geniculate nucleus medial dorsal nucleus lateral geniculate nucleus median eminence arcuate nucleus ciliary body nucleus accumbens inferior colliculi More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding magnesium ion binding metal ion binding kinase activity tau-protein kinase activity Cellular component cytoplasm nucleoplasm Biological process protein phosphorylation phosphorylation microtubule cytoskeleton organization intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23387 70661 Ensembl ENSG00000160584 ENSMUSG00000034135 UniProt Q9Y2K2 Q6P4S6 RefSeq (mRNA) NM_001281748 NM_001281749 NM_025164 NM_001366686 NM_001366687 NM_027498 RefSeq (protein) NP_001268677 NP_001268678 NP_079440 NP_001353615 NP_001353616 NP_081774 Location (UCSC) Chr 11: 116.84 – 117.1 Mb Chr 9: 45.92 – 46.14 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

KIAA0999 protein is a protein that in humans is encoded by the SIK3 gene. ^{[5] [6] [7]} It is part of the salt-inducible kinase family.

References

1. GRCh38: Ensembl release 89: ENSG00000160584 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034135 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (February 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (1): 63–70. doi: 10.1093/dnares/6.1.63 . PMID   10231032.
6. Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
7. "Entrez Gene: KIAA0999 KIAA0999 protein".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX   10.1.1.500.923 . doi:10.1093/dnares/9.3.99. PMID   12168954.
• Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR (February 2004). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". The EMBO Journal. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC   381014 . PMID   14976552.
• Petroziello J, Yamane A, Westendorf L, Thompson M, McDonagh C, Cerveny C, Law CL, Wahl A, Carter P (October 2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene. 23 (46): 7734–45. doi: 10.1038/sj.onc.1207921 . PMID   15334068.
• Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, Prescott AR, Alessi DR (December 2005). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK". Journal of Cell Science. 118 (Pt 23): 5661–73. doi: 10.1242/jcs.02670 . PMID   16306228.