MAPK4

MAPK4
Identifiers
Aliases	MAPK4 , ERK-4, ERK4, PRKM4, p63-MAPK, p63MAPK, mitogen-activated protein kinase 4
External IDs	OMIM: 176949; MGI: 2444559; HomoloGene: 2058; GeneCards: MAPK4; OMA:MAPK4 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18q21.1-q21.2 Start 50,560,087 bp [1] End 50,731,826 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 E2 Start 73,928,486 bp [2] End 74,065,359 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in caudate nucleus nucleus accumbens right frontal lobe anterior cingulate cortex putamen right adrenal cortex right hemisphere of cerebellum left adrenal cortex amygdala prefrontal cortex Top expressed in olfactory tubercle habenula visual cortex Epithelium of choroid plexus superior frontal gyrus primary visual cortex primary motor cortex prefrontal cortex globus pallidus cingulate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein serine/threonine kinase activity ATP binding kinase activity protein heterodimerization activity nucleotide binding protein kinase binding protein homodimerization activity protein kinase activity transferase activity protein binding MAP kinase activity Cellular component cytosol nucleoplasm nucleus cytoplasm Biological process protein phosphorylation cell cycle phosphorylation MAPK cascade regulation of gene expression cellular response to organic substance intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5596 225724 Ensembl ENSG00000141639 ENSG00000282110 ENSMUSG00000024558 UniProt P31152 Q6P5G0 RefSeq (mRNA) NM_001292039 NM_001292040 NM_002747 NM_172632 NM_001360936 RefSeq (protein) NP_001278968 NP_001278969 NP_002738 NP_766220 NP_001347865 Location (UCSC) Chr 18: 50.56 – 50.73 Mb Chr 18: 73.93 – 74.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mitogen-activated protein kinase 4 is an enzyme that in humans is encoded by the MAPK4 gene. ^{[5] [6]}

Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets. ^[6]

The Arabidopsis MAPK4 is important in signalling ^[7]

Mechanistically, MAPK4 directly bound and activated AKT by phosphorylation of the activation loop at threonine 308. It also activated mTORC2 to phosphorylate AKT at serine 473 for full activation. MAPK4 overexpression induced oncogenic outcomes, including transforming prostate epithelial cells into anchorage-independent growth, and MAPK4 knockdown inhibited cancer cell proliferation, anchorage-independent growth, and xenograft growth. ^[8]

References

1. ENSG00000282110 GRCh38: Ensembl release 89: ENSG00000141639, ENSG00000282110 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024558 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Li L, Wysk M, Gonzalez FA, Davis RJ (February 1994). "Genomic loci of human mitogen-activated protein kinases". Oncogene. 9 (2): 647–9. PMID   8290275.
6. "Entrez Gene: MAPK4 mitogen-activated protein kinase 4".
7. Petersen M, Brodersen P, Naested H, Andreasson E, Lindhart U, Johansen B, et al. (December 2000). "Arabidopsis map kinase 4 negatively regulates systemic acquired resistance". Cell. 103 (7): 1111–20. doi: 10.1016/S0092-8674(00)00213-0 . PMID   11163186. S2CID   1864451.
8. Wang W, Shen T, Dong B, Creighton CJ, Meng Y, Zhou W, et al. (March 2019). "MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling". The Journal of Clinical Investigation. 129 (3): 1015–1029. doi:10.1172/JCI97712. PMC   6391107 . PMID   30688659.

Further reading

• Seger R, Krebs EG (June 1995). "The MAPK signaling cascade". FASEB Journal. 9 (9): 726–35. doi: 10.1096/fasebj.9.9.7601337 . PMID   7601337. S2CID   23298305.
• Davis RJ (December 1995). "Transcriptional regulation by MAP kinases". Molecular Reproduction and Development. 42 (4): 459–67. doi:10.1002/mrd.1080420414. PMID   8607977. S2CID   12842112.
• Robinson MJ, Cobb MH (April 1997). "Mitogen-activated protein kinase pathways". Current Opinion in Cell Biology. 9 (2): 180–6. doi:10.1016/S0955-0674(97)80061-0. PMID   9069255.
• Gonzalez FA, Raden DL, Rigby MR, Davis RJ (June 1992). "Heterogeneous expression of four MAP kinase isoforms in human tissues". FEBS Letters. 304 (2–3): 170–8. Bibcode:1992FEBSL.304..170G. doi:10.1016/0014-5793(92)80612-K. PMID   1319925. S2CID   42548392.
• Zhu AX, Zhao Y, Moller DE, Flier JS (December 1994). "Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3". Molecular and Cellular Biology. 14 (12): 8202–11. doi:10.1128/mcb.14.12.8202. PMC   359359 . PMID   7969157.
• Kinet S, Bernard F, Mongellaz C, Perreau M, Goldman FD, Taylor N (October 2002). "gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes". Blood. 100 (7): 2546–53. doi: 10.1182/blood-2002-03-0819 . PMID   12239168.
• Sun M, Wei Y, Yao L, Xie J, Chen X, Wang H, et al. (February 2006). "Identification of extracellular signal-regulated kinase 3 as a new interaction partner of cyclin D3". Biochemical and Biophysical Research Communications. 340 (1): 209–14. Bibcode:2006BBRC..340..209S. doi:10.1016/j.bbrc.2005.12.003. PMID   16360641.
• Kant S, Schumacher S, Singh MK, Kispert A, Kotlyarov A, Gaestel M (November 2006). "Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5". The Journal of Biological Chemistry. 281 (46): 35511–9. doi: 10.1074/jbc.M606693200 . PMID   16973613.

External links

• MAP Kinase Resource Archived 2021-04-15 at the Wayback Machine