PSKH1

PSKH1
Identifiers
Aliases	PSKH1 , protein serine kinase H1
External IDs	OMIM: 177015; MGI: 3528383; HomoloGene: 48461; GeneCards: PSKH1; OMA:PSKH1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q22.1 Start 67,893,254 bp [1] End 67,929,676 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 D3 Start 106,627,073 bp [2] End 106,658,410 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium mucosa of transverse colon apex of heart body of stomach body of pancreas right coronary artery popliteal artery tibial arteries left ovary left adrenal cortex Top expressed in hand genital tubercle zygote internal carotid artery tail of embryo external carotid artery secondary oocyte foot maxillary prominence mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein binding ATP binding protein serine/threonine kinase activity Cellular component cytoplasm Golgi apparatus nuclear speck endoplasmic reticulum membrane membrane plasma membrane microtubule organizing center endoplasmic reticulum cytoskeleton nucleus intracellular anatomical structure nucleoplasm cellular component Biological process phosphorylation protein phosphorylation heart development determination of left/right symmetry peptidyl-serine phosphorylation peptidyl-threonine phosphorylation intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5681 244631 Ensembl ENSG00000159792 ENSMUSG00000048310 UniProt P11801 Q91YA2 RefSeq (mRNA) NM_006742 NM_173432 RefSeq (protein) NP_006733 NP_775608 Location (UCSC) Chr 16: 67.89 – 67.93 Mb Chr 8: 106.63 – 106.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein Serine/threonine-protein kinase H1 is a Ser/Thr protein kinase that is encoded by the PSKH1 gene in humans and is associated with organelle membranes. PSKH1 resides within, and transits between, organelles in the human secretory pathway notably the Endoplasmic Reticulum. ^{[5] [6]}

Interactions

PSKH1 is a regulated protein kinase with a defined substrate specificity, which has been shown to interact with (and be regulated by) proteins of the Cab45, reticulocalbin, Erc55, and calumenin family of calcium-binding proteins and calmodulin. It is also activated by UNC119B, an acyl chain binding protein. ^[7] . PSKH1 is closely related to the catalytically-inactive pseudokinase PSKH2, which is also membrane-localised within the secretory pathway. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000159792 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048310 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Larsen F, Solheim J, Kristensen T, Kolstø AB, Prydz H (February 1994). "A tight cluster of five unrelated human genes on chromosome 16q22.1". Hum Mol Genet. 2 (10): 1589–95. doi:10.1093/hmg/2.10.1589. PMID   8268911.
6. "Entrez Gene: PSKH1 protein serine kinase H1".
7. Horne CR, Young SY, Mather LJ, Dagley LF, Johnson JL, Yaron-Barir TM, Huntsman EM, Daly LA, Byrne DP, Cadell AL, Ng BH, Yousef J, Multari DH, Shen L, McAloon LM, Manning G, Febbraio MA, Means AR, Cantley LC, Tanzer MC, Croucher DR, Eyers CE, Eyers PA, Scott JW, and Murphy JM (February 2025). "PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins". PNAS. 122 (8). doi:10.1073/pnas.2420961122. PMC   11873932 . PMID   39964718.
8. Byrne DP, Shrestha S, Daly LA, Marensi V, Ramakrishnan K, Eyers CE, Kannan N, and Eyers PA (January 2023). "Evolutionary and cellular analysis of the 'dark' pseudokinase PSKH2". Biochemical Journal. 480 (2): 141–160. doi:10.1042/BCJ20220474. PMC   11873932 . PMID   39964718.

Further reading

• Hanks SK (1987). "Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family". Proc. Natl. Acad. Sci. U.S.A. 84 (2): 388–92. Bibcode:1987PNAS...84..388H. doi: 10.1073/pnas.84.2.388 . PMC   304212 . PMID   2948189.
• Petersen BO, Lukas J, Sørensen CS, Bartek J, Helin K (1999). "Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization". EMBO J. 18 (2): 396–410. doi:10.1093/emboj/18.2.396. PMC   1171134 . PMID   9889196.
• Amarzguioui M, Brede G, Babaie E, Grotli M, Sproat B, Prydz H (2000). "Secondary structure prediction and in vitro accessibility of mRNA as tools in the selection of target sites for ribozymes". Nucleic Acids Res. 28 (21): 4113–24. doi:10.1093/nar/28.21.4113. PMC   113158 . PMID   11058107.
• Brede G, Solheim J, Tröen G, Prydz H (2001). "Characterization of PSKH1, a novel human protein serine kinase with centrosomal, golgi, and nuclear localization". Genomics. 70 (1): 82–92. doi:10.1006/geno.2000.6365. PMID   11087665.
• Brede G, Solheim J, Prydz H (2002). "PSKH1, a novel splice factor compartment-associated serine kinase". Nucleic Acids Res. 30 (23): 5301–9. doi:10.1093/nar/gkf648. PMC   137962 . PMID   12466556.
• Brede G, Solheim J, Stang E, Prydz H (2004). "Mutants of the protein serine kinase PSKH1 disassemble the Golgi apparatus". Exp. Cell Res. 291 (2): 299–312. doi:10.1016/j.yexcr.2003.07.009. PMID   14644153.