PSKH1

PSKH1
Identifiers
Aliases	PSKH1 , protein serine kinase H1
External IDs	OMIM: 177015 MGI: 3528383 HomoloGene: 48461 GeneCards: PSKH1
Gene location (Human)
Chr.	Chromosome 16 (human)
End	67,929,676 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	106,658,410 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; body of stomach; ; body of pancreas; ; right coronary artery; ; popliteal artery; ; right adrenal gland; ; left coronary artery; ; left uterine tube; ; thoracic aorta; ; ascending aorta;
	Top expressed in
	hand; ; internal carotid artery; ; external carotid artery; ; secondary oocyte; ; foot; ; maxillary prominence; ; molar; ; proximal tubule; ; lip; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; protein kinase activity ; kinase activity ; protein binding ; ATP binding ; protein serine/threonine kinase activity ;
Cellular component	cytoplasm ; Golgi apparatus ; nuclear speck ; endoplasmic reticulum membrane ; membrane ; plasma membrane ; microtubule organizing center ; endoplasmic reticulum ; cytoskeleton ; nucleus ; intracellular anatomical structure ; nucleoplasm ; cellular component ;
Biological process	phosphorylation ; protein phosphorylation ; heart development ; determination of left/right symmetry ; peptidyl-serine phosphorylation ; peptidyl-threonine phosphorylation ; intracellular signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	5681
	244631
	ENSG00000159792
	ENSMUSG00000048310
	P11801
	Q91YA2
	NM_006742
	NM_173432
	NP_006733
	NP_775608
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated February 01, 2024

Serine/threonine-protein kinase H1 is an enzyme that in humans is encoded by the PSKH1 gene.^[5]^[6]

Interactions

PSKH1 has been shown to interact with CDC6.^[7]

Related Research Articles

Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved. In fact, yeast cells can proliferate normally when their CDK gene has been replaced with the homologous human gene. CDKs are relatively small proteins, with molecular weights ranging from 34 to 40 kDa, and contain little more than the kinase domain. By definition, a CDK binds a regulatory protein called a cyclin. Without cyclin, CDK has little kinase activity; only the cyclin-CDK complex is an active kinase but its activity can be typically further modulated by phosphorylation and other binding proteins, like p27. CDKs phosphorylate their substrates on serines and threonines, so they are serine-threonine kinases. The consensus sequence for the phosphorylation site in the amino acid sequence of a CDK substrate is [S/T*]PX[K/R], where S/T* is the phosphorylated serine or threonine, P is proline, X is any amino acid, K is lysine, and R is arginine.

Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the CDK2 gene. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, also known as Cdk1 in humans. It is a catalytic subunit of the cyclin-dependent kinase complex, whose activity is restricted to the G1-S phase of the cell cycle, where cells make proteins necessary for mitosis and replicate their DNA. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin E or A. Cyclin E binds G1 phase Cdk2, which is required for the transition from G1 to S phase while binding with Cyclin A is required to progress through the S phase. Its activity is also regulated by phosphorylation. Multiple alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. The role of this protein in G1-S transition has been recently questioned as cells lacking Cdk2 are reported to have no problem during this transition.

Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. It has been highly studied in the budding yeast S. cerevisiae, and the fission yeast S. pombe, where it is encoded by genes cdc28 and cdc2, respectively. With its cyclin partners, Cdk1 forms complexes that phosphorylate a variety of target substrates ; phosphorylation of these proteins leads to cell cycle progression.

Cyclin-dependent kinase 7, or cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene.

M-phase inducer phosphatase 1 also known as dual specificity phosphatase Cdc25A is a protein that in humans is encoded by the cell division cycle 25 homolog A (CDC25A) gene.

G1/S-specific cyclin-D2 is a protein that in humans is encoded by the CCND2 gene.

Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.

Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.

Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene.

Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene.

Transcription factor E2F2 is a protein that in humans is encoded by the E2F2 gene.

Cyclin-A2 is a protein that in humans is encoded by the CCNA2 gene. It is one of the two types of cyclin A: cyclin A1 is expressed during meiosis and embryogenesis while cyclin A2 is expressed in the mitotic division of somatic cells.

Cyclin-H is a protein that in humans is encoded by the CCNH gene.

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene. This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes.

Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the CDC7 gene. The Cdc7 kinase is involved in regulation of the cell cycle at the point of chromosomal DNA replication. The gene CDC7 appears to be conserved throughout eukaryotic evolution; this means that most eukaryotic cells have the Cdc7 kinase protein.

Cyclin-dependent kinase inhibitor 3 is an enzyme that in humans is encoded by the CDKN3 gene.

MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene.

Protein NPAT also known as nuclear protein of the ATM locus is a protein that in humans is encoded by the NPAT gene.

Serine/threonine-protein kinase, Intestinal cell kinase or ICK is an enzyme that in humans is encoded by the ICK gene.

Origin recognition complex subunit 1 is a protein that in humans is encoded by the ORC1 gene. It is closely related to CDC6, and both are the same protein in archaea.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000159792 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048310 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Larsen F, Solheim J, Kristensen T, Kolstø AB, Prydz H (February 1994). "A tight cluster of five unrelated human genes on chromosome 16q22.1". Hum Mol Genet. 2 (10): 1589–95. doi:10.1093/hmg/2.10.1589. PMID 8268911.
↑ "Entrez Gene: PSKH1 protein serine kinase H1".
↑ Petersen BO, Lukas J, Sørensen CS, Bartek J, Helin K (January 1999). "Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization". EMBO J. 18 (2): 396–410. doi:10.1093/emboj/18.2.396. PMC 1171134 . PMID 9889196.

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

PSKH1

Contents

Interactions

Related Research Articles

References

Further reading