TRIO (gene)

Last updated

TRIO
Protein TRIO PDB 1nty.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TRIO , ARHGEF23, tgat, trio Rho guanine nucleotide exchange factor, MEBAS, MRD44, MRD63, TRIO gene
External IDs OMIM: 601893; MGI: 1927230; HomoloGene: 20847; GeneCards: TRIO; OMA:TRIO - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007118

NM_001081302

RefSeq (protein)

NP_009049

NP_001074771

Location (UCSC) Chr 5: 14.14 – 14.53 Mb Chr 15: 27.73 – 28.03 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Triple functional domain protein is a protein that in humans is encoded by the TRIO gene. [5] [6]

Contents

Interactions

TRIO (gene) has been shown to interact with Filamin [7] and RHOA. [8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000038382 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022263 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Debant A, Serra-Pagès C, Seipel K, O'Brien S, Tang M, Park SH, Streuli M (May 1996). "The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains". Proceedings of the National Academy of Sciences of the United States of America. 93 (11): 5466–71. Bibcode:1996PNAS...93.5466D. doi: 10.1073/pnas.93.11.5466 . PMC   39269 . PMID   8643598.
  6. "Entrez Gene: TRIO triple functional domain (PTPRF interacting)".
  7. Bellanger JM, Astier C, Sardet C, Ohta Y, Stossel TP, Debant A (Dec 2000). "The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin". Nature Cell Biology. 2 (12): 888–92. doi:10.1038/35046533. PMID   11146652. S2CID   10182923.
  8. Medley QG, Serra-Pagès C, Iannotti E, Seipel K, Tang M, O'Brien SP, Streuli M (Nov 2000). "The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain". The Journal of Biological Chemistry. 275 (46): 36116–23. doi: 10.1074/jbc.M003775200 . PMID   10948190.

Further reading