MAP3K13

MAP3K13
Identifiers
Aliases	MAP3K13 , LZK, MEKK13, MLK, mitogen-activated protein kinase kinase kinase 13
External IDs	OMIM: 604915 MGI: 2444243 HomoloGene: 37958 GeneCards: MAP3K13
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q27.2 Start 185,282,941 bp [1] End 185,489,094 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 B1 Start 21,613,096 bp [2] End 21,752,189 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis caput epididymis sperm lower lobe of lung lactiferous duct pons inferior ganglion of vagus nerve pylorus renal medulla retinal pigment epithelium Top expressed in ureter ganglionic eminence jejunum cerebellum cerebellar cortex colon duodenum superior frontal gyrus renal cortex liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein homodimerization activity identical protein binding kinase activity MAP kinase kinase kinase activity protein serine/threonine kinase activity protein kinase activity ATP binding protein kinase binding metal ion binding nucleotide binding transferase activity JUN kinase kinase kinase activity IkappaB kinase complex binding enzyme binding Cellular component membrane cytoplasm IkappaB kinase complex Biological process phosphorylation JNK cascade protein phosphorylation protein autophosphorylation positive regulation of NF-kappaB transcription factor activity MAPK cascade positive regulation of neuron maturation peptidyl-serine phosphorylation positive regulation of axon extension positive regulation of neuron projection arborization positive regulation of branching morphogenesis of a nerve Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9175 71751 Ensembl ENSG00000073803 ENSMUSG00000033618 UniProt O43283 Q1HKZ5 RefSeq (mRNA) NM_001242314 NM_001242317 NM_004721 NM_172821 RefSeq (protein) NP_001229243 NP_001229246 NP_004712 NP_766409 Location (UCSC) Chr 3: 185.28 – 185.49 Mb Chr 16: 21.61 – 21.75 Mb PubMed search [3] [4]
Wikidata
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Mitogen-activated protein kinase kinase kinase 13 is an enzyme that in humans is encoded by the MAP3K13 gene. ^{[5] [6]}

Function

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. ^[6]

Interactions

MAP3K13 has been shown to interact with PRDX3. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000073803 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033618 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sakuma H, Ikeda A, Oka S, Kozutsumi Y, Zanetta JP, Kawasaki T (Dec 1997). "Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain". J Biol Chem. 272 (45): 28622–9. doi: 10.1074/jbc.272.45.28622 . PMID   9353328.
6. "Entrez Gene: MAP3K13 mitogen-activated protein kinase kinase kinase 13".
7. Masaki M, Ikeda A, Shiraki E, Oka S, Kawasaki T (Jan 2003). "Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically". Eur. J. Biochem. 270 (1): 76–83. doi: 10.1046/j.1432-1033.2003.03363.x . PMID   12492477.

Further reading

• Masaki M, Ikeda A, Shiraki E, Oka S, Kawasaki T (2003). "Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically". Eur. J. Biochem. 270 (1): 76–83. doi: 10.1046/j.1432-1033.2003.03363.x . PMID   12492477.
• Ikeda A, Sakuma H, Masaki M, Kozutsumi Y, Oka S, Inazawa J, Kawasaki T (2002). "Genomic organization and fine-mapping of the human leucine zipper-bearing kinase (LZK) gene". J. Biochem. Mol. Biol. Biophys. 6 (2): 113–7. doi:10.1080/10258140290027243. PMID   12186766.
• Ikeda A, Hasegawa K, Masaki M, Moriguchi T, Nishida E, Kozutsumi Y, Oka S, Kawasaki T (2002). "Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway". J. Biochem. 130 (6): 773–81. doi:10.1093/oxfordjournals.jbchem.a003048. PMID   11726277.
• Ikeda A, Masaki M, Kozutsumi Y, Oka S, Kawasaki T (2001). "Identification and characterization of functional domains in a mixed lineage kinase LZK". FEBS Lett. 488 (3): 190–5. doi: 10.1016/S0014-5793(00)02432-7 . PMID   11163770. S2CID   44379847.
• Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID   8274451.