PRKAB2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | PRKAB2 , protein kinase AMP-activated non-catalytic subunit beta 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 602741; MGI: 1336185; HomoloGene: 38046; GeneCards: PRKAB2; OMA:PRKAB2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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5'-AMP-activated protein kinase subunit beta-2 is an enzyme that in humans is encoded by the PRKAB2 gene. [5] [6]
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. [6]
PRKAB2 has been shown to interact with PRKAG2 [7] and PRKAG1. [7]
Research on the genes CHD1L and PRKAB2 within lymphoblast cells [8] lead to the conclusion that anomalies appear with the 1q21.1 deletion syndrome: