SGK3

SGK3
Identifiers
Aliases	SGK3 , CISK, SGK2, SGKL, serum/glucocorticoid regulated kinase family member 3
External IDs	OMIM: 607591 MGI: 2182368 HomoloGene: 56582 GeneCards: SGK3
Gene location (Human)
Chr.	Chromosome 8 (human)
End	66,862,022 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	9,900,845 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• transferase activity ; • protein kinase activity ; • nucleotide binding ; • sodium channel regulator activity ; • calcium channel regulator activity ; • kinase activity ; • potassium channel regulator activity ; • GO:0001948 protein binding ; • phosphatidylinositol binding ; • chloride channel regulator activity ; • ATP binding ; • protein serine/threonine kinase activity ;
Cellular component	• recycling endosome ; • cytosol ; • endosome ; • early endosome ; • cytoplasmic vesicle ;
Biological process	• regulation of apoptotic process ; • GO:0007243 intracellular signal transduction ; • regulation of cell migration ; • positive regulation of transporter activity ; • phosphorylation ; • protein phosphorylation ; • ion transmembrane transport ; • regulation of cell proliferation ; • peptidyl-serine phosphorylation ; • regulation of sequence-specific DNA binding transcription factor activity ; • regulation of cell growth ; • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ;
	Sources:Amigo / QuickGO
Orthologs
	23678
	170755
	ENSG00000104205
	ENSMUSG00000025915
	Q96BR1
	Q9ERE3
	NM_170709 ; NM_001033578 ; NM_013257
	NM_001037759 ; NM_133220 ; NM_177547
	NP_001191102 ; NP_001028750 ; NP_037389 ; NP_733827
	NP_001032848 ; NP_573483 ; NP_808215
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 06, 2020

Serine/threonine-protein kinase Sgk3 is an enzyme that in humans is encoded by the SGK3 gene.^[5]^[6]^[7]

Function

This gene is a member of the serine/threonine protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[7]

In melanocytic cells SGK3 gene expression may be regulated by MITF.^[8]

Interactions

SGK3 has been shown to interact with GSK3B.^[9]

Related Research Articles

Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. First discovered in 1980 as a regulatory kinase for its namesake, glycogen synthase (GS), GSK-3 has since been identified as a protein kinase for over 100 different proteins in a variety of different pathways. In mammals, including humans, GSK-3 exists in two isoforms encoded by two paralogous genes GSK-3α (GSK3A) and GSK-3β (GSK3B). GSK-3 has been the subject of much research since it has been implicated in a number of diseases, including type 2 diabetes, Alzheimer's disease, inflammation, cancer, and bipolar disorder.

RAC-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 domains. It is commonly referred to as PKB, or by both names as "Akt/PKB".

Protein kinase C delta type is an enzyme that in humans is encoded by the PRKCD gene.

Glycogen synthase kinase 3 beta, also known as GSK3B, is an enzyme that in humans is encoded by the GSK3B gene. In mice, the enzyme is encoded by the GSK-3β gene. Abnormal regulation and expression of GSK3β is associated with an increased susceptibility towards bipolar disorder.

Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMKIIα), a.k.a.Ca²⁺/calmodulin-dependent protein kinase II alpha, is one subunit of CamKII, a protein kinase (i.e., an enzyme which phosphorylates proteins) that in humans is encoded by the CAMK2A gene.

RAC-beta serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT2 gene.

Serine/threonine-protein kinases SGK represent a kinase subfamily with orthologs found across animal clades and in yeast. In most vertebrates, including humans, there are three isoforms encoded by the genes SGK1, SGK2, and SGK3. The name Serum/glucocorticoid-regulated kinase refers to the first cloning of a SGK family member from a cDNA library screen for genes upregulated by the glucocorticoid dexamethasone in a rat mammary epithelial tumor cell line. The first human family member was cloned in a screen of hepatocellular genes regulated in response to cellular hydration or swelling.

Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the MAPK7 gene.

Neural precursor cell expressed developmentally downregulated gene 4-like (NEDD4L) or NEDD4-2 is an enzyme of the NEDD4 family. In human the protein is encoded by the NEDD4L gene. In mouse the protein is commonly known as NEDD4-2 and the gene Nedd4-2.

Sodium-hydrogen exchange regulatory cofactor NHE-RF2 (NHERF-2) also known as tyrosine kinase activator protein 1 (TKA-1) or SRY-interacting protein 1 (SIP-1) is a protein that in humans is encoded by the SLC9A3R2 gene.

RAC-gamma serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT3 gene.

5'-AMP-activated protein kinase subunit gamma-2 is an enzyme that in humans is encoded by the PRKAG2 gene.

Serine/threonine-protein kinase D3 (PKD3) or PKC-nu is an enzyme that in humans is encoded by the PRKD3 gene.

Serine/threonine-protein kinase Nek6 is an enzyme that in humans is encoded by the NEK6 gene.

Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene.

Calcium/calmodulin-dependent protein kinase kinase 2 is an enzyme that in humans is encoded by the CAMKK2 gene.

Serine/threonine-protein kinase Sgk2 is an enzyme that in humans is encoded by the SGK2 gene.

Mitogen-activated protein kinase 10 also known as c-Jun N-terminal kinase 3 (JNK3) is an enzyme that in humans is encoded by the MAPK10 gene.

In the field of biochemistry, PDPK1 refers to the protein 3-phosphoinositide-dependent protein kinase-1, an enzyme which is encoded by the PDPK1 gene in humans. It is implicated in the development and progression of melanomas.

Serine/threonine-protein kinase Sgk1 also known as serum and glucocorticoid-regulated kinase 1 is an enzyme that in humans is encoded by the SGK1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000104205 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025915 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dai F, Yu L, He H, Zhao Y, Yang J, Zhang X, Zhao S (February 2000). "Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1". Genomics. 62 (1): 95–7. doi:10.1006/geno.1999.5969. PMID 10585774.
↑ Kobayashi T, Deak M, Morrice N, Cohen P (January 2000). "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase". Biochem J. 344 Pt 1 (Pt 1): 189–97. doi:10.1042/0264-6021:3440189. PMC 1220630 . PMID 10548550.
1 2 "Entrez Gene: SGK3 serum/glucocorticoid regulated kinase family, member 3".
↑ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
↑ Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S (May 2002). "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction". Biochem. Biophys. Res. Commun. 293 (4): 1191–6. doi:10.1016/S0006-291X(02)00349-2. PMID 12054501.

Lang F, Cohen P (2002). "Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms". Sci. STKE. 2001 (108): RE17. doi:10.1126/stke.2001.108.re17. PMID 11707620. S2CID 25927734.
Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8): 2527–40. doi:10.1021/cr000110o. PMID 11749387.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Fang X, Yu SX, Lu Y, Bast RC, Woodgett JR, Mills GB (2000). "Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A". Proc. Natl. Acad. Sci. U.S.A. 97 (22): 11960–5. doi:10.1073/pnas.220413597. PMC 17277 . PMID 11035810.
Xu J, Liu D, Gill G, Songyang Z (2001). "Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides". J. Cell Biol. 154 (4): 699–705. doi:10.1083/jcb.200105089. PMC 2196448 . PMID 11514587.
Yun CC, Chen Y, Lang F (2002). "Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2". J. Biol. Chem. 277 (10): 7676–83. doi: 10.1074/jbc.M107768200 . PMID 11751930.
Fang X, Yu S, Tanyi JL, Lu Y, Woodgett JR, Mills GB (2002). "Convergence of Multiple Signaling Cascades at Glycogen Synthase Kinase 3: Edg Receptor-Mediated Phosphorylation and Inactivation by Lysophosphatidic Acid through a Protein Kinase C-Dependent Intracellular Pathway". Mol. Cell. Biol. 22 (7): 2099–110. doi:10.1128/MCB.22.7.2099-2110.2002. PMC 133668 . PMID 11884598.
Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S (2002). "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction". Biochem. Biophys. Res. Commun. 293 (4): 1191–6. doi:10.1016/S0006-291X(02)00349-2. PMID 12054501.
Brickley DR, Mikosz CA, Hagan CR, Conzen SD (2003). "Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1)". J. Biol. Chem. 277 (45): 43064–70. doi: 10.1074/jbc.M207604200 . PMID 12218062.
Gamper N, Fillon S, Feng Y, Friedrich B, Lang PA, Henke G, Huber SM, Kobayashi T, Cohen P, Lang F (2003). "K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK". Pflügers Arch. 445 (1): 60–6. doi:10.1007/s00424-002-0873-2. PMID 12397388. S2CID 21073737.
Henke G, Setiawan I, Böhmer C, Lang F (2003). "Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms". Kidney Blood Press. Res. 25 (6): 370–4. doi:10.1159/000068699. PMID 12590200. S2CID 30241243.
Friedrich B, Feng Y, Cohen P, Risler T, Vandewalle A, Bröer S, Wang J, Pearce D, Lang F (2003). "The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC". Pflügers Arch. 445 (6): 693–6. doi:10.1007/s00424-002-0993-8. PMID 12632189. S2CID 32511608.
Embark HM, Böhmer C, Vallon V, Luft F, Lang F (2003). "Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms". Pflügers Arch. 445 (5): 601–6. doi:10.1007/s00424-002-0982-y. PMID 12634932. S2CID 22981271.
Nilsen T, Slagsvold T, Skjerpen CS, Brech A, Stenmark H, Olsnes S (2004). "Peroxisomal targeting as a tool for assaying protein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner". J. Biol. Chem. 279 (6): 4794–801. doi: 10.1074/jbc.M309653200 . PMID 14604990.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000104205 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025915 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10585774-5] Dai F, Yu L, He H, Zhao Y, Yang J, Zhang X, Zhao S (February 2000). "Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1". Genomics. 62 (1): 95–7. doi:10.1006/geno.1999.5969. PMID 10585774.

[pmid10548550-6] Kobayashi T, Deak M, Morrice N, Cohen P (January 2000). "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase". Biochem J. 344 Pt 1 (Pt 1): 189–97. doi:10.1042/0264-6021:3440189. PMC 1220630 . PMID 10548550.

[entrez-7] 1 2 "Entrez Gene: SGK3 serum/glucocorticoid regulated kinase family, member 3".

[pmid19067971-8] Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

[pmid12054501-9] Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S (May 2002). "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction". Biochem. Biophys. Res. Commun. 293 (4): 1191–6. doi:10.1016/S0006-291X(02)00349-2. PMID 12054501.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

SGK3

Contents

Function

Interactions

Related Research Articles

References

Further reading