TPK1

Last updated
TPK1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TPK1 , HPP20, THMD5, thiamin pyrophosphokinase 1
External IDs OMIM: 606370 MGI: 1352500 HomoloGene: 6960 GeneCards: TPK1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013861
NM_001311111

RefSeq (protein)

NP_001298040
NP_038889

Location (UCSC) Chr 7: 144.45 – 144.84 Mb Chr 6: 43.32 – 43.64 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Thiamin pyrophosphokinase 1 is an enzyme that in humans is encoded by the TPK1 gene. [5] [6]

This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [6]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000196511 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029735 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nosaka K, Onozuka M, Kakazu N, Hibi S, Nishimura H, Nishino H, Abe T (May 2001). "Isolation and characterization of a human thiamine pyrophosphokinase cDNA". Biochim Biophys Acta. 1517 (2): 293–7. doi:10.1016/s0167-4781(00)00247-5. PMID   11342111.
  6. 1 2 "Entrez Gene: TPK1 thiamin pyrophosphokinase 1".

Further reading