STK10

STK10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2J7T, 4AOT, 4BC6, 4EQU, 4USD, 4USE, 5AJQ
Identifiers
Aliases	STK10 , LOK, PRO2729, serine/threonine kinase 10
External IDs	OMIM: 603919; MGI: 1099439; HomoloGene: 38122; GeneCards: STK10; OMA:STK10 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q35.1 Start 172,042,079 bp [1] End 172,188,224 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 18.97 cM|11 A4 Start 32,483,305 bp [2] End 32,574,587 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte sural nerve blood monocyte spleen cerebellar hemisphere right hemisphere of cerebellum bone marrow cells upper lobe of left lung lymph node Top expressed in granulocyte mesenteric lymph nodes blood spleen sciatic nerve seminiferous tubule decidua bone marrow intestinal villus external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein homodimerization activity kinase activity protein binding identical protein binding ATP binding protein serine/threonine kinase activity Cellular component cytoplasm membrane extracellular exosome plasma membrane specific granule membrane Biological process lymphocyte aggregation phosphorylation regulation of lymphocyte migration protein autophosphorylation cell cycle protein phosphorylation neutrophil degranulation regulation of mitotic cell cycle signal transduction stress-activated protein kinase signaling cascade activation of protein kinase activity regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6793 20868 Ensembl ENSG00000072786 ENSMUSG00000020272 UniProt O94804 O55098 RefSeq (mRNA) NM_005990 NM_009288 NM_001359177 NM_001359178 RefSeq (protein) NP_005981 NP_033314 NP_001346106 NP_001346107 Location (UCSC) Chr 5: 172.04 – 172.19 Mb Chr 11: 32.48 – 32.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10 gene. ^{[5] [6]}

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000072786 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020272 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kuramochi S, Matsuda Y, Okamoto M, Kitamura F, Yonekawa H, Karasuyama H (Jun 1999). "Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues". Immunogenetics. 49 (5): 369–75. doi:10.1007/s002510050509. PMID   10199912. S2CID   877572.
6. "Entrez Gene: STK10 serine/threonine kinase 10".

Further reading

• Kuramochi S, Moriguchi T, Kuida K, et al. (1997). "LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes". J. Biol. Chem. 272 (36): 22679–84. doi: 10.1074/jbc.272.36.22679 . PMID   9278426.
• Tao L, Wadsworth S, Mercer J, et al. (2002). "Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells". Biochem. J. 363 (Pt 1): 175–82. doi:10.1042/0264-6021:3630175. PMC   1222464 . PMID   11903060.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Walter SA, Cutler RE, Martinez R, et al. (2003). "Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue". J. Biol. Chem. 278 (20): 18221–8. doi: 10.1074/jbc.M212556200 . PMID   12639966.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Bignell G, Smith R, Hunter C, et al. (2006). "Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults". Genes Chromosomes Cancer. 45 (1): 42–6. doi:10.1002/gcc.20265. PMC   7212027 . PMID   16175573.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi: 10.1074/mcp.T600062-MCP200 . hdl: 10033/19756 . PMID   17192257.