DCLK1

DCLK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MFW, 1MG4, 1UF0
Identifiers
Aliases	DCLK1 , CL1, CLICK1, DCAMKL1, DCDC3A, DCLK, doublecortin like kinase 1
External IDs	OMIM: 604742; MGI: 1330861; HomoloGene: 130530; GeneCards: DCLK1; OMA:DCLK1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q13.3 Start 35,768,652 bp [1] End 36,131,382 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 C Start 55,149,785 bp [2] End 55,446,489 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell frontal pole Brodmann area 10 Brodmann area 23 pars reticulata pars compacta occipital lobe middle temporal gyrus superior vestibular nucleus primary visual cortex Top expressed in stria vascularis Rostral migratory stream piriform cortex vestibular sensory epithelium habenula visual cortex superior frontal gyrus primary visual cortex primary motor cortex prefrontal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding kinase activity ATP binding protein serine/threonine kinase activity Cellular component integral component of plasma membrane intracellular anatomical structure postsynaptic density Biological process cell differentiation axonogenesis dendrite morphogenesis phosphorylation response to virus neuron migration nervous system development multicellular organism development endosomal transport protein phosphorylation central nervous system development brain development axon extension forebrain development central nervous system projection neuron axonogenesis negative regulation of protein localization to nucleus peptidyl-serine phosphorylation peptidyl-threonine phosphorylation intracellular signal transduction neuron projection morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9201 13175 Ensembl ENSG00000133083 ENSMUSG00000027797 UniProt O15075 Q9JLM8 RefSeq (mRNA) NM_001195415 NM_001195416 NM_001195430 NM_004734 NM_001330071 NM_001330072 NM_001111051 NM_001111052 NM_001111053 NM_001195538 NM_001195539 NM_001195540 NM_019978 NM_001357466 NM_001357468 NM_001357469 NM_001357475 NM_001357476 RefSeq (protein) NP_001182344 NP_001182345 NP_001182359 NP_001317000 NP_001317001 NP_004725 NP_001104521 NP_001104522 NP_001104523 NP_001182467 NP_001182468 NP_001182469 NP_064362 NP_001344395 NP_001344397 NP_001344398 NP_001344404 NP_001344405 Location (UCSC) Chr 13: 35.77 – 36.13 Mb Chr 3: 55.15 – 55.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Doublecortin-like kinase protein 1 (DCLK1) ^{[5] [6] [7] [8]} is an enzyme that in humans is encoded by the DCLK1 gene. ^{[5] [6] [8]} Its C-terminal domain in rats is expressed independently from an alternative transcript, cpg16, and can function alone as a serine/threonine protein kinase that is cyclic AMP dependent. ^{[9] [10]}

DCLK1 expression is a marker for tuft cells, a type of chemosensory cell of the intestinal epithelium. ^{[7] [11]}

References

1. GRCh38: Ensembl release 89: ENSG00000133083 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027797 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Omori Y, Suzuki M, Ozaki K, Harada Y, Nakamura Y, Takahashi E, Fujiwara T (Oct 1998). "Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin". J Hum Genet. 43 (3): 169–77. doi: 10.1007/s100380050063 . PMID   9747029.
6. Sossey-Alaoui K, Srivastava AK (May 1999). "DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX)". Genomics. 56 (1): 121–6. doi:10.1006/geno.1998.5718. PMID   10036192.
7. Ding L, Weygant N, Ding C, Lai Y, Li H (2023). "DCLK1 and tuft cells: Immune-related functions and implications for cancer immunotherapy". Critical Reviews in Oncology and Hematology. 191 104118. doi:10.1016/j.critrevonc.2023.104118. PMID   37660932.
8. "Entrez Gene: DCAMKL1 doublecortin and CaM kinase-like 1". Gene. National Library of Medicine. 7 April 2024. Retrieved 30 May 2024.
9. Silverman MA, Benard O, Jaaro H, Rattner A, Citri Y, Seger R (1999). "CPG16, a novel protein serine/threonine kinase downstream of cAMP-dependent protein kinase". Journal of Biological Chemistry. 274 (5): 2631–2636. doi: 10.1074/jbc.274.5.2631 . PMID   9915791.
10. Lin PT, Gleeson JG, Corbo JC, et al. (2001). "DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization". J. Neurosci. 20 (24): 9152–61. doi: 10.1523/JNEUROSCI.20-24-09152.2000 . PMC   6773030 . PMID   11124993.
11. Gerbe F, Legraverend C, Jay P (2012). "The intestinal epithelium tuft cells: specification and function". Cellular and Molecular Life Sciences. 69 (17): 2907–2917. doi: 10.1007/s00018-012-0984-7 . PMC   3417095 . PMID   22527717.

Further reading

• Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi: 10.1093/dnares/4.2.141 . PMID   9205841.
• Matsumoto N, Pilz DT, Ledbetter DH (1999). "Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS)". Genomics. 56 (2): 179–83. doi:10.1006/geno.1998.5673. PMID   10051403.
• Burgess HA, Reiner O (2002). "Alternative splice variants of doublecortin-like kinase are differentially expressed and have different kinase activities". J. Biol. Chem. 277 (20): 17696–705. doi: 10.1074/jbc.M111981200 . PMID   11884394.
• Kim MH, Derewenda U, Devedjiev Y, et al. (2003). "Purification and crystallization of the N-terminal domain from the human doublecortin-like kinase". Acta Crystallogr. D. 59 (Pt 3): 502–5. Bibcode:2003AcCrD..59..502K. doi:10.1107/S0907444903000027. PMID   12595708.
• Kim MH, Cierpicki T, Derewenda U, et al. (2003). "The DCX-domain tandems of doublecortin and doublecortin-like kinase". Nat. Struct. Biol. 10 (5): 324–33. doi:10.1038/nsb918. PMID   12692530. S2CID   10173864.
• Seet LF, Liu N, Hanson BJ, Hong W (2004). "Endofin recruits TOM1 to endosomes". J. Biol. Chem. 279 (6): 4670–9. doi: 10.1074/jbc.M311228200 . PMID   14613930.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID   15345747.

External links

• Overview of all the structural information available in the PDB for UniProt : O15075 (Serine/threonine-protein kinase DCLK1) at the PDBe-KB .