LATS2

LATS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZRI
Identifiers
Aliases	LATS2 , KPM, large tumor suppressor kinase 2
External IDs	OMIM: 604861 MGI: 1354386 HomoloGene: 56678 GeneCards: LATS2
Gene location (Human)
Chr.	Chromosome 13 (human)
End	21,061,586 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	57,995,845 bp
RNA expression pattern
	Top expressed in
	pancreatic epithelial cell; ; visceral pleura; ; parietal pleura; ; tibialis anterior muscle; ; tibia; ; germinal epithelium; ; lower lobe of lung; ; amniotic fluid; ; saphenous vein; ; pericardium;
	Top expressed in
	ascending aorta; ; aortic valve; ; external carotid artery; ; sciatic nerve; ; internal carotid artery; ; spermatid; ; left lung lobe; ; plantaris muscle; ; carotid body; ; substantia nigra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; protein kinase activity ; metal ion binding ; kinase activity ; protein binding ; ATP binding ; protein serine/threonine kinase activity ;
Cellular component	spindle pole ; microtubule organizing center ; cytoskeleton ; nucleus ; cytoplasm ; cytosol ;
Biological process	intracellular signal transduction ; phosphorylation ; negative regulation of cyclin-dependent protein serine/threonine kinase activity ; cell division ; protein phosphorylation ; peptidyl-serine phosphorylation ; hormone-mediated signaling pathway ; positive regulation of apoptotic process ; cell cycle ; G1/S transition of mitotic cell cycle ; hippo signaling ; regulation of organ growth ; negative regulation of canonical Wnt signaling pathway ; inner cell mass cell fate commitment ; inner cell mass cellular morphogenesis ; keratinocyte differentiation ;
	Sources:Amigo / QuickGO
Orthologs
	26524
	50523
	ENSG00000150457
	ENSMUSG00000021959
	Q9NRM7
	Q7TSJ6
	NM_014572
	NM_015771 ; NM_153382
	NP_055387
	NP_056586 ; NP_700431
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 06, 2022

Large tumor suppressor kinase 2 (LATS2) is an enzyme that in humans is encoded by the LATS2 gene.^[5]^[6]

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family and participates in the Hippo signaling pathway where it inactivates the effector proteins, YAP and WWTR1 (TAZ). The protein localizes to centrosomes during interphase and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a corepressor of androgen-responsive gene expression.^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000150457 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021959 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H (Apr 2000). "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts". Genomics. 63 (2): 263–70. doi:10.1006/geno.1999.6065. PMID 10673337.
1 2 "Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)".

Hori T, Takaori-Kondo A, Kamikubo Y, Uchiyama T (2000). "Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor". Oncogene. 19 (27): 3101–9. doi: 10.1038/sj.onc.1203659 . PMID 10871863.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Li Y, Pei J, Xia H, et al. (2003). "Lats2, a putative tumor suppressor, inhibits G1/S transition". Oncogene. 22 (28): 4398–405. doi: 10.1038/sj.onc.1206603 . PMID 12853976.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Powzaniuk M, McElwee-Witmer S, Vogel RL, et al. (2005). "The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor". Mol. Endocrinol. 18 (8): 2011–23. doi: 10.1210/me.2004-0065 . PMID 15131260.
Toji S, Yabuta N, Hosomi T, et al. (2005). "The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase". Genes Cells. 9 (5): 383–97. doi: 10.1111/j.1356-9597.2004.00732.x . PMID 15147269.
Ke H, Pei J, Ni Z, et al. (2004). "Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L)". Exp. Cell Res. 298 (2): 329–38. doi:10.1016/j.yexcr.2004.04.031. PMID 15265683.
Chan EH, Nousiainen M, Chalamalasetty RB, et al. (2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1". Oncogene. 24 (12): 2076–86. doi:10.1038/sj.onc.1208445. PMID 15688006. S2CID 27285160.
Takahashi Y, Miyoshi Y, Takahata C, et al. (2005). "Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers". Clin. Cancer Res. 11 (4): 1380–5. doi: 10.1158/1078-0432.CCR-04-1773 . PMID 15746036.
Abe Y, Ohsugi M, Haraguchi K, et al. (2006). "LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis". FEBS Lett. 580 (3): 782–8. doi: 10.1016/j.febslet.2005.12.096 . PMID 16413547.
Voorhoeve PM, le Sage C, Schrier M, et al. (2006). "A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors". Cell. 124 (6): 1169–81. doi: 10.1016/j.cell.2006.02.037 . PMID 16564011.
Aylon Y, Michael D, Shmueli A, et al. (2007). "A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization". Genes Dev. 20 (19): 2687–700. doi:10.1101/gad.1447006. PMC 1578695 . PMID 17015431.
Jiang Z, Li X, Hu J, et al. (2007). "Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma". Neurosci. Res. 56 (4): 450–8. doi:10.1016/j.neures.2006.09.006. PMID 17049657. S2CID 22763208.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000150457 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021959 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10673337-5] Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H (Apr 2000). "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts". Genomics. 63 (2): 263–70. doi:10.1006/geno.1999.6065. PMID 10673337.

[entrez-6] 1 2 "Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)".

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

LATS2

Related Research Articles

References

Further reading