PASK

For the airport in Alaska with ICAO code PASK, see Selawik Airport.

PASK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LL8, 3DLS
Identifiers
Aliases	PASK , PASKIN, STK37, PAS domain containing serine/threonine kinase
External IDs	OMIM: 607505 MGI: 2155936 HomoloGene: 9038 GeneCards: PASK
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q37.3 Start 241,106,099 bp [1] End 241,150,264 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 D Start 93,236,492 bp [2] End 93,271,204 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube oocyte secondary oocyte lymph node appendix caudate nucleus putamen nucleus accumbens left lobe of thyroid gland blood Top expressed in spermatocyte spermatid otic placode saccule seminiferous tubule primitive streak morula somite maxillary prominence Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase activity transferase activity nucleotide binding protein kinase activity protein binding ATP binding phosphatidylinositol binding lipid binding protein serine/threonine kinase activity Cellular component nucleus cytosol cytoplasm Biological process regulation of respiratory gaseous exchange protein autophosphorylation negative regulation of glycogen biosynthetic process positive regulation of translation regulation of glucagon secretion phosphorylation protein phosphorylation energy homeostasis intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23178 269224 Ensembl ENSG00000115687 ENSMUSG00000026274 UniProt Q96RG2 Q8CEE6 RefSeq (mRNA) NM_001252119 NM_001252120 NM_001252122 NM_001252124 NM_015148 NM_080850 RefSeq (protein) NP_001239048 NP_001239049 NP_001239051 NP_001239053 NP_055963 NP_543126 Location (UCSC) Chr 2: 241.11 – 241.15 Mb Chr 1: 93.24 – 93.27 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

PAS domain-containing serine/threonine-protein kinase is an enzyme that in humans is encoded by the PASK gene. ^{[5] [6] [7] [8]}

PAS domains regulate the function of many intracellular signaling pathways in response to both extrinsic and intrinsic stimuli. PASK is an evolutionarily conserved protein present in yeast, flies, and mammals.[supplied by OMIM] ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000115687 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026274 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hofer T, Spielmann P, Stengel P, Stier B, Katschinski DM, Desbaillets I, Gassmann M, Wenger RH (Nov 2001). "Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors" (PDF). Biochem Biophys Res Commun. 288 (4): 757–64. doi:10.1006/bbrc.2001.5840. PMID   11688972.
6. Rutter J, Michnoff CH, Harper SM, Gardner KH, McKnight SL (Aug 2001). "PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase". Proc Natl Acad Sci U S A. 98 (16): 8991–6. Bibcode:2001PNAS...98.8991R. doi: 10.1073/pnas.161284798 . PMC   55361 . PMID   11459942.
7. da Silva Xavier G, Rutter J, Rutter GA (Jun 2004). "Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose". Proc Natl Acad Sci U S A. 101 (22): 8319–24. Bibcode:2004PNAS..101.8319D. doi: 10.1073/pnas.0307737101 . PMC   420392 . PMID   15148392.
8. "Entrez Gene: PASK PAS domain containing serine/threonine kinase".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi: 10.1093/dnares/2.4.167 . PMID   8590280.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Ceulemans H, Van Eynde A, Pérez-Callejón E, et al. (1999). "Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1". Eur. J. Biochem. 262 (1): 36–42. doi: 10.1046/j.1432-1327.1999.00344.x . PMID   10231361.
• Amezcua CA, Harper SM, Rutter J, Gardner KH (2003). "Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation". Structure. 10 (10): 1349–61. doi: 10.1016/S0969-2126(02)00857-2 . PMID   12377121.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Eckhardt K, Troger J, Reissmann J, et al. (2007). "Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1". Cell. Physiol. Biochem. 20 (1–4): 227–40. doi: 10.1159/000104169 . PMID   17595531.
• Kikani CK, Antonysamy SA, Bonanno JB, et al. (2010). "Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation". J. Biol. Chem. 285 (52): 41034–43. doi: 10.1074/jbc.M110.157594 . PMC   3003402 . PMID   20943661.