List of EC numbers (EC 4)

Last updated

This list contains a list of EC numbers for the fourth group, EC 4, lyases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.

The Enzyme Commission number is a numerical classification scheme for enzymes, based on the chemical reactions they catalyze. As a system of enzyme nomenclature, every EC number is associated with a recommended name for the respective enzyme.

The International Union of Biochemistry and Molecular Biology (IUBMB) is an international non-governmental organisation concerned with biochemistry and molecular biology. Formed in 1955 as the International Union of Biochemistry, the union has presently 77 member countries.

Contents

EC 4.1: Carbon-Carbon Lyases

EC 4.1.1: Carboxy-Lyases

Pyruvate decarboxylase

Pyruvate decarboxylase is a homotetrameric enzyme that catalyses the decarboxylation of pyruvic acid to acetaldehyde and carbon dioxide in the cytoplasm of prokaryotes, and in the cytoplasm and mitochondria of eukaryotes. It is also called 2-oxo-acid carboxylase, alpha-ketoacid carboxylase, and pyruvic decarboxylase. In anaerobic conditions, this enzyme is part of the fermentation process that occurs in yeast, especially of the genus Saccharomyces, to produce ethanol by fermentation. It is also present in some species of fish where it permits the fish to perform ethanol fermentation when oxygen is scarce. Pyruvate decarboxylase starts this process by converting pyruvate into acetaldehyde and carbon dioxide. Pyruvate decarboxylase depends on cofactors thiamine pyrophosphate (TPP) and magnesium. This enzyme should not be mistaken for the unrelated enzyme pyruvate dehydrogenase, an oxidoreductase, that catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA.

Oxalate decarboxylase class of enzymes

In enzymology, an oxalate decarboxylase (EC 4.1.1.2) is an enzyme that catalyzes the chemical reaction

Oxaloacetate decarboxylase is a carboxy-lyase involved in the conversion of oxaloacetate into pyruvate.

EC 4.1.2: Aldehyde-Lyases

In enzymology, a ketotetrose-phosphate aldolase is an enzyme that catalyzes the chemical reaction

In enzymology, a deoxyribose-phosphate aldolase is an enzyme that catalyzes the chemical reaction

In enzymology, a threonine aldolase is an enzyme that catalyzes the chemical reaction

EC 4.1.3: Oxo-Acid-Lyases

Isocitrate lyase class of enzymes

Isocitrate lyase, or ICL, is an enzyme in the glyoxylate cycle that catalyzes the cleavage of isocitrate to succinate and glyoxylate. Together with malate synthase, it bypasses the two decarboxylation steps of the tricarboxylic acid cycle and is used by bacteria, fungi, and plants.

N-acetylneuraminate lyase

In enzymology, a N-acetylneuraminate lyase is an enzyme that catalyzes the chemical reaction

Citrate (pro-3S)-lyase class of enzymes

In enzymology, a citrate (pro-3S)-lyase is an enzyme that catalyzes the chemical reaction

EC 4.1.99: Other Carbon-Carbon Lyases

Tryptophanase class of enzymes

In enzymology, a tryptophanase (EC 4.1.99.1) is an enzyme that catalyzes the chemical reaction

In enzymology, a tyrosine phenol-lyase (EC 4.1.99.2) is an enzyme that catalyzes the chemical reaction

In enzymology, an octadecanal decarbonylase is an enzyme that catalyzes the chemical reaction

EC 4.2: Carbon-Oxygen Lyases

EC 4.2.1: Hydro-lyases

In enzymology, an arabinonate dehydratase (EC 4.2.1.5) is an enzyme that catalyzes the chemical reaction

In enzymology, a galactonate dehydratase (EC 4.2.1.6) is an enzyme that catalyzes the chemical reaction

In enzymology, an altronate dehydratase (EC 4.2.1.7) is an enzyme that catalyzes the chemical reaction

EC 4.2.2: Acting on Polysaccharides

EC 4.2.3: Acting on phosphates

EC 4.2.99: Other Carbon-Oxygen Lyases

EC 4.3: Carbon-Nitrogen Lyases

EC 4.3.1: Ammonia-Lyases

EC 4.3.2: Amidine-Lyases

EC 4.3.3: Amine-Lyases

EC 4.3.99: Other Carbon-Nitrogen Lyases

EC 4.4: Carbon-Sulfur Lyases

EC 4.5: Carbon-Halide Lyases

EC 4.6: Phosphorus-Oxygen Lyases

EC 4.99: Other Lyases

Related Research Articles

In biochemistry, a lyase is an enzyme that catalyzes the breaking of various chemical bonds by means other than hydrolysis and oxidation, often forming a new double bond or a new ring structure. The reverse reaction is also possible. For example, an enzyme that catalyzed this reaction would be a lyase:

The crotonase family comprises mechanistically diverse proteins that share a conserved trimeric quaternary structure, the core of which consists of 4 turns of a (beta/beta/alpha)n superhelix.

In enzymology, an erythro-3-hydroxyaspartate ammonia-lyase (EC 4.3.1.20) is an enzyme that catalyzes the chemical reaction

In enzymology, a glucosaminate ammonia-lyase (EC 4.3.1.9) is an enzyme that catalyzes the chemical reaction

In enzymology, a 2-dehydro-3-deoxy-6-phosphogalactonate aldolase is an enzyme that catalyzes the chemical reaction

In enzymology, a 3-dehydro-L-gulonate-6-phosphate decarboxylase (EC 4.1.1.85) is an enzyme that catalyzes the chemical reaction

In enzymology, a 5-dehydro-2-deoxyphosphogluconate aldolase is an enzyme that catalyzes the chemical reaction

In enzymology, a dehydro-L-gulonate decarboxylase (EC 4.1.1.34) is an enzyme that catalyzes the chemical reaction

In enzymology, a 5alpha-hydroxysteroid dehydratase (EC 4.2.1.62) is an enzyme that catalyzes the chemical reaction

In enzymology, an ATP-dependent NAD(P)H-hydrate dehydratase is an enzyme that catalyzes the chemical reaction

In enzymology, a 3-deoxy-8-phosphooctulonate synthase (EC 2.5.1.55) is an enzyme that catalyzes the chemical reaction

DAHP synthase class of enzymes

3-Deoxy-D-arabinoheptulosonate 7-phosphate (DAHP) synthase is the first enzyme in a series of metabolic reactions known as the shikimate pathway, which is responsible for the biosynthesis of the amino acids phenylalanine, tyrosine, and tryptophan. Since it is the first enzyme in the shikimate pathway, it controls the amount of carbon entering the pathway. Enzyme inhibition is the primary method of regulating the amount of carbon entering the pathway. Forms of this enzyme differ between organisms, but can be considered DAHP synthase based upon the reaction that is catalyzed by this enzyme.

ADP-dependent NAD(P)H-hydrate dehydratase is an enzyme with systematic name (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase . This enzyme catalyses the following chemical reaction

Threo-3-hydroxy-D-aspartate ammonia-lyase (EC 4.3.1.27, D-threo-3-hydroxyaspartate dehydratase) is an enzyme with systematic name threo-3-hydroxy-D-aspartate ammonia-lyase (oxaloacetate-forming). This enzyme catalyses the following chemical reaction

Dihydrodipicolinate synthase class of enzymes

4-Hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7, dihydrodipicolinate synthase, dihydropicolinate synthetase, dihydrodipicolinic acid synthase, L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing), dapA (gene)) is an enzyme with the systematic name L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing; (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate-forming). This enzyme catalyses the following chemical reaction

References

  1. "Enzyme: 4.1.2.8". Kyoto Encyclopedia of Genes and Genomes. Retrieved 2017-04-07.
  2. European Bioinformatics Institute. "EC 4.1.2.8". Integrated relational Enzyme database. Retrieved 2017-04-07.