2-methylisoborneol synthase

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2-methylisoborneol synthase
Identifiers
EC no. 4.2.3.118
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PRIAM profile
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NCBI proteins

2-methylisoborneol synthase (EC 4.2.3.118, sco7700, 2-MIB cyclase, MIB synthase, MIBS) is an enzyme with systematic name (E)-2-methylgeranyl-diphosphate diphosphate-lyase (cyclizing, 2-methylisoborneol-forming). [1] [2] [3] This enzyme catalyses the following chemical reaction

(E)-2-methylgeranyl diphosphate + H2O 2-methylisoborneol + diphosphate

The product, 2-methylisoborneol, is a characteristic odiferous compound with a musty smell produced by soil microorganisms.

References

  1. Wang CM, Cane DE (July 2008). "Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor". Journal of the American Chemical Society. 130 (28): 8908–9. Bibcode:2008JAChS.130.8908W. doi:10.1021/ja803639g. PMC   3023297 . PMID   18563898.
  2. Komatsu M, Tsuda M, Omura S, Oikawa H, Ikeda H (May 2008). "Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol". Proceedings of the National Academy of Sciences of the United States of America. 105 (21): 7422–7. Bibcode:2008PNAS..105.7422K. doi: 10.1073/pnas.0802312105 . PMC   2387273 . PMID   18492804.
  3. Giglio S, Chou WK, Ikeda H, Cane DE, Monis PT (February 2011). "Biosynthesis of 2-methylisoborneol in cyanobacteria". Environmental Science & Technology. 45 (3): 992–8. Bibcode:2011EnST...45..992G. doi:10.1021/es102992p. PMC   3699865 . PMID   21174459.