3-Isopropylmalate dehydratase

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3-isopropylmalate dehydratase
Identifiers
EC no. 4.2.1.33
CAS no. 37290-72-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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PMC articles
PubMed articles
NCBI proteins

3-Isopropylmalate dehydratase (EC 4.2.1.33) is an aconitase homologue, [1] [2] [3] which catalyses the isomerisation of 2-isopropylmalate to 3-isopropylmalate, via dehydration, in the biosynthesis of leucine.

References

  1. Gross SR, Burns RO, Umbarger HE (1963). "The biosynthesis of leucine. II. The enzymic isomerization of beta-carboxy-beta-hydroxyisocaproate and alpha-hydroxy-beta-carboxyisocaproate". Biochemistry. 2 (5): 1046–52. doi:10.1021/bi00905a023. PMID   14087357.
  2. Calvo JM, Stevens CM, Kalyanpur MG, Umbarger HE (December 1964). "The absolute configuration of alpha-hydroxy-beta-carboxyisocaproic acid (3-isopropylmalic acid), an intermediate in leucine biosynthesis". Biochemistry. 3 (12): 2024–7. doi:10.1021/bi00900a043. PMID   14269331.
  3. Cole FE, Kalyanpur MG, Stevens CM (August 1973). "Absolute configuration of alpha isopropylmalate and the mechanism of its conversion to beta isopropylmalate in the biosynthesis of leucine". Biochemistry. 12 (17): 3346–50. doi:10.1021/bi00741a031. PMID   4270046.