Dihydroneopterin aldolase

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dihydroneopterin aldolase
5f3m.jpg
oktamer
Identifiers
EC no. 4.1.2.25
CAS no. 37290-59-8
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BRENDA BRENDA entry
ExPASy NiceZyme view
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MetaCyc metabolic pathway
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Gene Ontology AmiGO / QuickGO
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NCBI proteins
Dihydroneopterin aldolase
PDB 1sql EBI.jpg
crystal structure of 7,8-dihydroneopterin aldolase in complex with guanine
Identifiers
SymbolFolB
Pfam PF02152
Pfam clan CL0334
InterPro IPR006157
SCOP2 1b9l / SCOPe / SUPFAM
Available protein structures:
Pfam   structures / ECOD  
PDB RCSB PDB; PDBe; PDBj
PDBsum structure summary

The enzyme dihydroneopterin aldolase (EC 4.1.2.25) catalyzes the chemical reaction

Contents

2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8- dihydropteridine 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropt eridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming). Other names in common use include 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-, and dihydropteridine glycolaldehyde-lyase. This enzyme participates in folate biosynthesis.

Structural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1NBU, 1RRI, 1RRW, 1RRY, 1RS2, 1RS4, 1RSD, 1RSI, 1U68, 1Z9W, 2CG8, 2NM2, and 2NM3.

Related Research Articles

<span class="mw-page-title-main">Dihydropteroate synthase</span> Class of enzymes

Dihydropteroate synthase is an enzyme classified under EC 2.5.1.15. It produces dihydropteroate in bacteria, but it is not expressed in most eukaryotes including humans. This makes it a useful target for sulfonamide antibiotics, which compete with the PABA precursor.

The enzyme erythro-3-hydroxyaspartate ammonia-lyase (EC 4.3.1.20) catalyzes the chemical reaction

The enzyme 2-dehydro-3-deoxy-D-pentonate aldolase catalyzes the chemical reaction

The enzyme 2-dehydro-3-deoxy-L-pentonate aldolase catalyzes the chemical reaction

The enzyme 3-deoxy-D-manno-octulosonate aldolase catalyzes the chemical reaction

The enzyme L-erythro-3-hydroxyaspartate aldolase catalyzes the chemical reaction

The enzyme 4-hydroxy-2-oxoglutarate aldolase catalyzes the chemical reaction

<span class="mw-page-title-main">4-hydroxy-2-oxovalerate aldolase</span> InterPro Family

The enzyme 4-hydroxy-2-oxovalerate aldolase catalyzes the chemical reaction

The enzyme 4-hydroxy-4-methyl-2-oxoglutarate aldolase catalyzes the chemical reaction

The enzyme benzoin aldolase catalyzes the chemical reaction

The enzyme propioin synthase catalyzes the chemical reaction

<span class="mw-page-title-main">6-Pyruvoyltetrahydropterin synthase</span> Class of enzymes

The enzyme 6-pyruvoyltetrahydropterin synthase catalyzes the following chemical reaction:

<span class="mw-page-title-main">Imidazoleglycerol-phosphate dehydratase</span>

The enzyme imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) catalyzes the chemical reaction

<span class="mw-page-title-main">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</span> Enzyme

In enzymology, a 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase is an enzyme that catalyzes the chemical reaction

7,8-Dihydroneopterin triphosphate (DHNTP) is an intermediate in tetrahydrobiopterin biosynthesis. It is transformed by 6-pyruvoyltetrahydropterin synthase into 6-pyruvoyl-tetrahydropterin. It is also used in the Queuosine/Archeosine Pathway.

<span class="mw-page-title-main">DAHP synthase</span> Class of enzymes

3-Deoxy-D-arabinoheptulosonate 7-phosphate (DAHP) synthase is the first enzyme in a series of metabolic reactions known as the shikimate pathway, which is responsible for the biosynthesis of the amino acids phenylalanine, tyrosine, and tryptophan. Since it is the first enzyme in the shikimate pathway, it controls the amount of carbon entering the pathway. Enzyme inhibition is the primary method of regulating the amount of carbon entering the pathway. Forms of this enzyme differ between organisms, but can be considered DAHP synthase based upon the reaction that is catalyzed by this enzyme.

7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase (EC 4.3.1.32, FO synthase) and 5-amino-6-(D-ribitylamino)uracil—L-tyrosine 4-hydroxyphenyl transferase (EC 2.5.1.147) are two enzymes always complexed together to achieve synthesis of FO, a precursor to Coenzyme F420. Their systematic names are 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil ammonia-lyase (7,8-didemethyl-8-hydroxy-5-deazariboflavin-forming) and 5-amino-6-(D-ribitylamino)uracil:L-tyrosine, 4-hydroxyphenyl transferase respectively. The enzymes catalyse the following chemical reactions:

<span class="mw-page-title-main">6-carboxytetrahydropterin synthase</span> Enzyme

6-carboxytetrahydropterin synthase (EC 4.1.2.50, CPH4 synthase, queD (gene), ToyB, ykvK (gene)) is an enzyme with systematic name 7,8-dihydroneopterin 3'-triphosphate acetaldehyde-lyase (6-carboxy-5,6,7,8-tetrahydropterin and triphosphate-forming). This enzyme catalyses the following reversible chemical reaction.

3-hydroxy-D-aspartate aldolase is an enzyme with systematic name 3-hydroxy-D-aspartate glyoxylate-lyase (glycine-forming). This enzyme catalyses the following chemical reaction

References


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