Valencene synthase

Valencene synthase
Identifiers
EC no.	4.2.3.73
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Valencene synthase (EC 4.2.3.73) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (valencene-forming). ^[1] It is a terpene cyclase enzyme responsible for the biosynthesis of valencene, a sesquiterpene, using farnesyl pyrophosphate as its substrate. The first such enzyme was isolated using orange cDNA. ^[2] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate ${\displaystyle \rightleftharpoons }$ (+)-valencene + diphosphate

The recombinant enzyme from Vitis vinifera forms (+)-valencene and (-)-7-epi-α-selinene.

References

1. Lücker J, Bowen P, Bohlmann J (October 2004). "Vitis vinifera terpenoid cyclases: functional identification of two sesquiterpene synthase cDNAs encoding (+)-valencene synthase and (-)-germacrene D synthase and expression of mono- and sesquiterpene synthases in grapevine flowers and berries". Phytochemistry. 65 (19): 2649–59. doi:10.1016/j.phytochem.2004.08.017. PMID   15464152.
2. Sharon-Asa L, Shalit M, Frydman A, Bar E, Holland D, Or E, et al. (December 2003). "Citrus fruit flavor and aroma biosynthesis: isolation, functional characterization, and developmental regulation of Cstps1, a key gene in the production of the sesquiterpene aroma compound valencene". The Plant Journal. Blackwell Publishing Ltd. 36 (5): 664–74. doi: 10.1046/j.1365-313x.2003.01910.x . PMID   14617067.

External links

• Valencene+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)