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Names | |
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Preferred IUPAC name (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-yl trihydrogen diphosphate | |
Identifiers | |
3D model (JSmol) | |
ChemSpider | |
MeSH | farnesyl+pyrophosphate |
PubChem CID | |
UNII | |
CompTox Dashboard (EPA) | |
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Properties | |
C15H28O7P2 | |
Molar mass | 382.330 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
Farnesyl pyrophosphate (FPP), also known as farnesyl diphosphate (FDP), is the precursor to all sesquiterpenes, which comprises thousands of compounds. [1] These include all sesquiterpenes as well as sterols and carotenoids. [2] It is also used in the synthesis of CoQ (part of the electron transport chain), as well as dehydrodolichol diphosphate (a precursor of dolichol, which transports proteins to the ER lumen for N-glycosylation).
Farnesyl pyrophosphate synthase (a prenyl transferase) [3] catalyzes sequential condensation reactions of dimethylallyl pyrophosphate with 2 units of 3-isopentenyl pyrophosphate to form farnesyl pyrophosphate:
The above reactions are inhibited by bisphosphonates (used for osteoporosis). [4] Farnesyl pyrophosphate is a selective agonist of TRPV3. [5]