ADCY1

Last updated
ADCY1
Identifiers
Aliases ADCY1 , AC1, DFNB44, adenylate cyclase 1 (brain), adenylate cyclase 1
External IDs OMIM: 103072; MGI: 99677; HomoloGene: 41419; GeneCards: ADCY1; OMA:ADCY1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001281768
NM_021116

NM_009622

RefSeq (protein)

NP_001268697
NP_066939

NP_033752

Location (UCSC) Chr 7: 45.57 – 45.72 Mb Chr 11: 7.01 – 7.13 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Adenylyl cyclase type 1 is an enzyme that in humans is encoded by the ADCY1 gene. [5] [6]

Contents

This gene encodes a form of adenylyl cyclase expressed in the brain. A similar protein in mice is involved in pattern formation of the brain. [6]

Function

ADCY1 is a calmodulin-sensitive adenylyl cyclase. In terms of function, It may be involved in regulatory processes in the central nervous system; specifically, it may play a role in memory acquisition and learning. It is inhibited by the G protein beta and gamma subunit complex. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000164742 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020431 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Villacres EC, Xia Z, Bookbinder LH, Edelhoff S, Disteche CM, Storm DR (May 1993). "Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase". Genomics. 16 (2): 473–8. doi:10.1006/geno.1993.1213. PMID   8314585.
  6. 1 2 "Entrez Gene: ADCY1 adenylyl cyclase 1 (brain)".
  7. "Gene Cards: ADCY1 Gene" . Retrieved 2012-12-30.

Further reading