ADCY5

ADCY5
Identifiers
Aliases	ADCY5 , AC5, FDFM, adenylate cyclase 5, DSKOD
External IDs	OMIM: 600293 MGI: 99673 HomoloGene: 11213 GeneCards: ADCY5
Gene location (Human)
Chr.	Chromosome 3 (human)
End	123,449,090 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	35,126,108 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; right coronary artery; ; popliteal artery; ; left ventricle; ; putamen; ; nucleus accumbens; ; caudate nucleus; ; ascending aorta; ; left coronary artery; ; prefrontal cortex;
	Top expressed in
	olfactory tubercle; ; nucleus accumbens; ; ascending aorta; ; globus pallidus; ; superior frontal gyrus; ; aortic valve; ; temporal lobe; ; amygdala; ; substantia nigra; ; ventromedial nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; adenylate cyclase binding ; metal ion binding ; lyase activity ; protein heterodimerization activity ; adenylate cyclase activity ; phosphorus-oxygen lyase activity ; ATP binding ; scaffold protein binding ; guanylate cyclase activity ;
Cellular component	integral component of membrane ; cell projection ; membrane ; plasma membrane ; cilium ; intermediate filament cytoskeleton ; guanylate cyclase complex, soluble ; integral component of plasma membrane ;
Biological process	cAMP biosynthetic process ; G protein-coupled adenosine receptor signaling pathway ; adenylate cyclase-activating dopamine receptor signaling pathway ; regulation of insulin secretion involved in cellular response to glucose stimulus ; intracellular signal transduction ; cellular response to forskolin ; adenylate cyclase-activating G protein-coupled receptor signaling pathway ; locomotory behavior ; neuromuscular process controlling balance ; positive regulation of cytosolic calcium ion concentration ; cellular response to glucagon stimulus ; cyclic nucleotide biosynthetic process ; adenylate cyclase-inhibiting dopamine receptor signaling pathway ; renal water homeostasis ; cGMP biosynthetic process ; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ; G protein-coupled receptor signaling pathway ; activation of adenylate cyclase activity ; activation of protein kinase A activity ;
	Sources:Amigo / QuickGO
Orthologs
	111
	224129
	ENSG00000173175
	ENSMUSG00000022840
	O95622
	P84309
	NM_001199642 ; NM_183357 ; NM_001378259
	NM_001012765
	NP_001186571 ; NP_899200 ; NP_001365188
	NP_001012783
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 25, 2024

Adenylyl cyclase type 5 is an enzyme that in humans is encoded by the ADCY5 gene.^[5]^[6]

Interactions

ADCY5 has been shown to interact with RGS2.^[7]

Clinical significance

Mutations in ADCY5 are known to cause the following conditions:^[8]

Dyskinesia with orofacial involvement, autosomal recessive (DSKOR);
Neurodevelopmental disorder with hyperkinetic movements and dyskinesia (NEDHYD).

Related Research Articles

Regulator of G-protein signaling 2 is a protein that in humans is encoded by the RGS2 gene. It is part of a larger family of RGS proteins that control signalling through G-protein coupled receptors (GPCR).

Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.

P2Y purinoceptor 11 is a protein that in humans is encoded by the P2RY11 gene.

Gamma-aminobutyric acid (GABA) B receptor, 2 (GABA_B2) is a G-protein coupled receptor subunit encoded by the GABBR2 gene in humans.

Taste receptor type 1 member 3 is a protein that in humans is encoded by the TAS1R3 gene. The TAS1R3 gene encodes the human homolog of mouse Sac taste receptor, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharin, and other sweeteners.

Calcium/calmodulin-dependent protein kinase type II gamma chain is an enzyme that in humans is encoded by the CAMK2G gene.

Protein kinase C eta type is an enzyme that in humans is encoded by the PRKCH gene.

Adenylyl cyclase type 6 is an enzyme that in humans is encoded by the ADCY6 gene.

G protein-activated inward rectifier potassium channel 2 is a protein that in humans is encoded by the KCNJ6 gene. Mutation in KCNJ6 gene has been proposed to be the cause of Keppen-Lubinsky Syndrome (KPLBS).

Adenylyl cyclase type 3 is an enzyme that in humans is encoded by the ADCY3 gene.

G protein-activated inward rectifier potassium channel 1(GIRK-1) is encoded in the human by the gene KCNJ3.

Adenylyl cyclase type 1 is an enzyme that in humans is encoded by the ADCY1 gene.

Adenylyl cyclase type 2 is an enzyme typically expressed in the brain of humans, that is encoded by the ADCY2 gene. It belongs to the adenylyl cyclase class-3 or guanylyl cyclase family because it contains two guanylate cyclase domains. ADCY2 is one of ten different mammalian isoforms of adenylyl cyclases. ADCY2 can be found on chromosome 5 and the "MIR2113-POU3F2" region of chromosome 6, with a length of 1091 amino-acids. An essential cofactor for ADCY2 is magnesium; two ions bind per subunit.

Adenylyl cyclase type 7 is an enzyme that in humans is encoded by the ADCY7 gene.

<span class="mw-page-title-main">ADCY9</span> Protein-coding gene in the species Homo sapiens

Adenylyl cyclase type 9 is an enzyme that in humans is encoded by the ADCY9 gene.

Guanine nucleotide-binding protein G(T) subunit gamma-T1 is a protein that in humans is encoded by the GNGT1 gene.

Adenylyl cyclase type 8 is an enzyme that in humans is encoded by the ADCY8 gene.

Adenylyl cyclase type 4 is an enzyme that in humans is encoded by the ADCY4 gene.

Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene.

Guanylate cyclase soluble subunit alpha-2 is an enzyme that in humans is encoded by the GUCY1A2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000173175 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022840 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Raimundo S, Giray J, Volff JN, Schwab M, Altenbuchner J, Ratge D, Wisser H (October 1999). "Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues". Clin Chim Acta. 285 (1–2): 155–61. doi:10.1016/S0009-8981(99)00067-4. PMID 10481931.
↑ "Entrez Gene: ADCY5 adenylate cyclase 5".
↑ Salim S, Sinnarajah S, Kehrl JH, Dessauer CW (May 2003). "Identification of RGS2 and type V adenylyl cyclase interaction sites". J. Biol. Chem. 278 (18): 15842–9. doi: 10.1074/jbc.M210663200 . PMID 12604604.
↑ "UniProt". www.uniprot.org. Retrieved 2023-07-04.

External links

Human ADCY5 genome location and ADCY5 gene details page in the UCSC Genome Browser .

Yoshimura M, Cooper DM (1992). "Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells". Proc. Natl. Acad. Sci. U.S.A. 89 (15): 6716–20. Bibcode:1992PNAS...89.6716Y. doi: 10.1073/pnas.89.15.6716 . PMC 49574 . PMID 1379717.
Iwami G, Kawabe J, Ebina T, Cannon PJ, Homcy CJ, Ishikawa Y (1995). "Regulation of adenylyl cyclase by protein kinase A". J. Biol. Chem. 270 (21): 12481–4. doi: 10.1074/jbc.270.21.12481 . PMID 7759492.
Haber N, Stengel D, Defer N, Roeckel N, Mattei MG, Hanoune J (1994). "Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI". Hum. Genet. 94 (1): 69–73. doi:10.1007/BF02272844. PMID 8034296. S2CID 6473135.
Kawabe J, Iwami G, Ebina T, Ohno S, Katada T, Ueda Y, Homcy CJ, Ishikawa Y (1994). "Differential activation of adenylyl cyclase by protein kinase C isoenzymes". J. Biol. Chem. 269 (24): 16554–8. doi: 10.1016/S0021-9258(19)89424-3 . PMID 8206971.
Scholich K, Barbier AJ, Mullenix JB, Patel TB (1997). "Characterization of soluble forms of nonchimeric type V adenylyl cyclases". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 2915–20. Bibcode:1997PNAS...94.2915S. doi: 10.1073/pnas.94.7.2915 . PMC 20297 . PMID 9096321.
Sunahara RK, Dessauer CW, Whisnant RE, Kleuss C, Gilman AG (1997). "Interaction of Gsalpha with the cytosolic domains of mammalian adenylyl cyclase". J. Biol. Chem. 272 (35): 22265–71. doi: 10.1074/jbc.272.35.22265 . PMID 9268375.
Scholich K, Wittpoth C, Barbier AJ, Mullenix JB, Patel TB (1997). "Identification of an intramolecular interaction between small regions in type V adenylyl cyclase that influences stimulation of enzyme activity by Gsα". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9602–7. Bibcode:1997PNAS...94.9602S. doi: 10.1073/pnas.94.18.9602 . PMC 23231 . PMID 9275169.
Dessauer CW, Tesmer JJ, Sprang SR, Gilman AG (1998). "Identification of a Gialpha binding site on type V adenylyl cyclase". J. Biol. Chem. 273 (40): 25831–9. doi: 10.1074/jbc.273.40.25831 . PMID 9748257.
Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Arch. 437 (4): 538–46. doi:10.1007/s004240050815. PMID 10089566. S2CID 7620262.
Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS. 14 (6): 629–36. doi: 10.1097/00002030-200004140-00001 . PMID 10807185. S2CID 22105709.
Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". J. Allergy Clin. Immunol. 105 (5): 975–82. doi: 10.1067/mai.2000.105315 . PMID 10808179.
Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". J. Neurochem. 77 (2): 399–407. doi: 10.1046/j.1471-4159.2001.00249.x . PMID 11299302. S2CID 24053412.
Côté M, Guillon G, Payet MD, Gallo-Payet N (2001). "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland". J. Clin. Endocrinol. Metab. 86 (9): 4495–503. doi: 10.1210/jcem.86.9.7837 . PMID 11549699.
Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Würzner R, Stoiber H, Lass-Flörl C, Dierich MP (2002). "Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons". J. Virol. 76 (7): 3179–88. doi:10.1128/JVI.76.7.3179-3188.2002. PMC 136041 . PMID 11884542.
Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". J. Recept. Signal Transduct. Res. 22 (1–4): 79–110. doi:10.1081/RRS-120014589. PMID 12503609. S2CID 36697419.
Salim S, Sinnarajah S, Kehrl JH, Dessauer CW (2003). "Identification of RGS2 and type V adenylyl cyclase interaction sites". J. Biol. Chem. 278 (18): 15842–9. doi: 10.1074/jbc.M210663200 . PMID 12604604.
Bauman AL, Soughayer J, Nguyen BT, Willoughby D, Carnegie GK, Wong W, Hoshi N, Langeberg LK, Cooper DM, Dessauer CW, Scott JD (2006). "Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes". Mol. Cell. 23 (6): 925–31. doi:10.1016/j.molcel.2006.07.025. PMC 3941446 . PMID 16973443.
Wang SC, Lai HL, Chiu YT, Ou R, Huang CL, Chern Y (2007). "Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor". Biochem J. 406 (3): 383–8. doi:10.1042/BJ20070512. PMC 2049038 . PMID 17593019.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000173175 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022840 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10481931-5] Raimundo S, Giray J, Volff JN, Schwab M, Altenbuchner J, Ratge D, Wisser H (October 1999). "Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues". Clin Chim Acta. 285 (1–2): 155–61. doi:10.1016/S0009-8981(99)00067-4. PMID 10481931.

[entrez-6] "Entrez Gene: ADCY5 adenylate cyclase 5".

[pmid12604604-7] Salim S, Sinnarajah S, Kehrl JH, Dessauer CW (May 2003). "Identification of RGS2 and type V adenylyl cyclase interaction sites". J. Biol. Chem. 278 (18): 15842–9. doi: 10.1074/jbc.M210663200 . PMID 12604604.

[:0-8] "UniProt". www.uniprot.org. Retrieved 2023-07-04.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)