Phosphoinositide phospholipase C is a family of eukaryotic intracellular enzymes that play an important role in signal transduction processes. These enzymes belong to a larger superfamily of Phospholipase C. Other families of phospholipase C enzymes have been identified in bacteria and trypanosomes. Phospholipases C are phosphodiesterases.
Glycosylphosphatidylinositol phospholipase D (EC 3.1.4.50, GPI-PLD, glycoprotein phospholipase D, phosphatidylinositol phospholipase D, phosphatidylinositol-specific phospholipase D) is an enzyme with systematic name glycoprotein-phosphatidylinositol phosphatidohydrolase. This enzyme catalyses the following chemical reaction
In enzymology, an inositol-3-phosphate synthase is an enzyme that catalyzes the chemical reaction
The enzyme glycosylphosphatidylinositol diacylglycerol-lyase catalyzes the reaction
The enzyme glycerophosphoinositol glycerophosphodiesterase (EC 3.1.4.44) catalyzes the reaction
The enzyme glycerophosphoinositol inositolphosphodiesterase (EC 3.1.4.43) is an enzyme that catalyzes the chemical reaction
The enzyme Inositol phosphate-phosphatase is of the phosphodiesterase family of enzymes. It is involved in the phosphophatidylinositol signaling pathway, which affects a wide array of cell functions, including but not limited to, cell growth, apoptosis, secretion, and information processing. Inhibition of inositol monophosphatase may be key in the action of lithium in treating bipolar disorder, specifically manic depression.
The enzyme phosphatidate phosphatase (PAP, EC 3.1.3.4) is a key regulatory enzyme in lipid metabolism, catalyzing the conversion of phosphatidate to diacylglycerol:
The enzyme phosphatidylinositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) that catalyzes the reaction
The enzyme phosphoinositide 5-phosphatase (EC 3.1.3.36) catalyzes the reaction
In enzymology, a N-acetylglucosaminylphosphatidylinositol deacetylase (EC 3.5.1.89) is an enzyme that catalyzes the chemical reaction
In enzymology, a 1-phosphatidylinositol-3-phosphate 5-kinase is an enzyme that catalyzes the chemical reaction
In enzymology, a 1-phosphatidylinositol 4-kinase is an enzyme that catalyzes the chemical reaction
In enzymology, 1-phosphatidylinositol-4-phosphate 5-kinase is an enzyme that catalyzes the chemical reaction
In enzymology, a CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a CDP-diacylglycerol—inositol 3-phosphatidyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a CDP-diacylglycerol—serine O-phosphatidyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, an inositol-tetrakisphosphate 1-kinase is an enzyme that catalyzes the chemical reaction
In enzymology, a phosphatidylinositol-4-phosphate 3-kinase is an enzyme that catalyzes the chemical reaction
Phospholipase C (PLC) is a class of membrane-associated enzymes that cleave phospholipids just before the phosphate group (see figure). It is most commonly taken to be synonymous with the human forms of this enzyme, which play an important role in eukaryotic cell physiology, in particular signal transduction pathways. Phospholipase C's role in signal transduction is its cleavage of phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), which serve as second messengers. Activators of each PLC vary, but typically include heterotrimeric G protein subunits, protein tyrosine kinases, small G proteins, Ca2+, and phospholipids.
