ADCY3

ADCY3
Identifiers
Aliases	ADCY3 , AC3, AC-III, adenylate cyclase 3, BMIQ19
External IDs	OMIM: 600291; MGI: 99675; HomoloGene: 2978; GeneCards: ADCY3; OMA:ADCY3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p23.3 Start 24,819,169 bp [1] End 24,920,237 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 A1.1 Start 4,183,103 bp [2] End 4,263,525 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibial nerve right ovary sural nerve left uterine tube canal of the cervix left ovary stromal cell of endometrium body of uterus ectocervix gastric mucosa Top expressed in gastrula olfactory epithelium brown adipose tissue lumbar subsegment of spinal cord subiculum submandibular gland ventromedial nucleus paraventricular nucleus of hypothalamus suprachiasmatic nucleus superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding metal ion binding calmodulin binding lyase activity phosphorus-oxygen lyase activity ATP binding adenylate cyclase activity guanylate cyclase activity Cellular component cytoplasm integral component of membrane Golgi apparatus cell projection membrane plasma membrane integral component of plasma membrane cilium guanylate cyclase complex, soluble Biological process cAMP biosynthetic process activation of protein kinase A activity intracellular signal transduction response to stimulus cellular response to glucagon stimulus cyclic nucleotide biosynthetic process sensory perception of smell renal water homeostasis signal transduction activation of adenylate cyclase activity cGMP biosynthetic process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway single fertilization acrosome reaction olfactory learning flagellated sperm motility cellular response to forskolin G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 109 104111 Ensembl ENSG00000138031 ENSMUSG00000020654 UniProt O60266 Q8VHH7 RefSeq (mRNA) NM_004036 NM_001320613 NM_001377128 NM_001377129 NM_001377130 NM_001377131 NM_001377132 NM_001159536 NM_001159537 NM_138305 RefSeq (protein) NP_001307542 NP_004027 NP_001364057 NP_001364058 NP_001364059 NP_001364060 NP_001364061 NP_001153008 NP_001153009 NP_612178 Location (UCSC) Chr 2: 24.82 – 24.92 Mb Chr 12: 4.18 – 4.26 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Adenylyl cyclase type 3 is an enzyme that in humans is encoded by the ADCY3 gene. ^{[5] [6]}

Function

This gene encodes adenylyl cyclase 3, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). ^[6]

The ADCY3 subtype likely mediates odorant detection (possibly) via modulation of intracellular cAMP concentration. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000138031 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020654 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yang B, He B, Abdel-Halim SM, Tibell A, Brendel MD, Bretzel RG, Efendic S, Hillert J (Jan 1999). "Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets". Biochemical and Biophysical Research Communications. 254 (3): 548–551. Bibcode:1999BBRC..254..548Y. doi:10.1006/bbrc.1998.9983. PMID   9920776.
6. "Entrez Gene: ADCY3 adenylate cyclase 3".
7. "Gene Cards: ADCY3 Gene" . Retrieved 2012-12-30.

External links

• Human ADCY3 genome location and ADCY3 gene details page in the UCSC Genome Browser .

Further reading

• Gaudin C, Homcy CJ, Ishikawa Y (Nov 1994). "Mammalian adenylyl cyclase family members are randomly located on different chromosomes". Human Genetics. 94 (5): 527–9. doi:10.1007/BF00211020. PMID   7959689. S2CID   40521157.
• Haber N, Stengel D, Defer N, Roeckel N, Mattei MG, Hanoune J (Jul 1994). "Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI". Human Genetics. 94 (1): 69–73. doi:10.1007/BF02272844. PMID   8034296. S2CID   6473135.
• Hellevuo K, Yoshimura M, Kao M, Hoffman PL, Cooper DM, Tabakoff B (Apr 1993). "A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line". Biochemical and Biophysical Research Communications. 192 (1): 311–318. Bibcode:1993BBRC..192..311H. doi:10.1006/bbrc.1993.1415. PMID   8476432.
• Wei J, Wayman G, Storm DR (Sep 1996). "Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo". The Journal of Biological Chemistry. 271 (39): 24231–24235. doi: 10.1074/jbc.271.39.24231 . PMID   8798667.
• Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–39. doi: 10.1093/dnares/5.1.31 . PMID   9628581.
• Wei J, Zhao AZ, Chan GC, Baker LP, Impey S, Beavo JA, Storm DR (Sep 1998). "Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in Neurons: a mechanism for attenuation of olfactory signals". Neuron. 21 (3): 495–504. doi: 10.1016/S0896-6273(00)80561-9 . PMID   9768837. S2CID   9860137.
• Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP (Mar 1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Archiv. 437 (4): 538–546. doi:10.1007/s004240050815. PMID   10089566. S2CID   7620262.
• Speth C, Joebstl B, Barcova M, Dierich MP (Apr 2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS. 14 (6): 629–636. doi: 10.1097/00002030-200004140-00001 . PMID   10807185. S2CID   22105709.
• Patke CL, Shearer WT (May 2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". The Journal of Allergy and Clinical Immunology. 105 (5): 975–982. doi: 10.1067/mai.2000.105315 . PMID   10808179.
• Vanvooren V, Allgeier A, Cosson E, Van Sande J, Defer N, Pirlot M, Hanoune J, Dumont JE (Dec 2000). "Expression of multiple adenylyl cyclase isoforms in human and dog thyroid". Molecular and Cellular Endocrinology. 170 (1–2): 185–196. doi:10.1016/S0303-7207(00)00322-1. PMID   11162902. S2CID   20099267.
• Patrizio M, Colucci M, Levi G (Apr 2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". Journal of Neurochemistry. 77 (2): 399–407. doi: 10.1046/j.1471-4159.2001.00249.x . PMID   11299302. S2CID   24053412.
• Côté M, Guillon G, Payet MD, Gallo-Payet N (Sep 2001). "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland". The Journal of Clinical Endocrinology and Metabolism. 86 (9): 4495–4503. doi: 10.1210/jcem.86.9.7837 . PMID   11549699.
• Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Würzner R, Stoiber H, Lass-Flörl C, Dierich MP (Apr 2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons". Journal of Virology. 76 (7): 3179–3188. doi:10.1128/JVI.76.7.3179-3188.2002. PMC   136041 . PMID   11884542.
• Kobayakawa K, Hayashi R, Morita K, Miyamichi K, Oka Y, Tsuboi A, Sakano H (Jul 2002). "Stomatin-related olfactory protein, SRO, specifically expressed in the murine olfactory sensory neurons". The Journal of Neuroscience. 22 (14): 5931–7. doi:10.1523/JNEUROSCI.22-14-05931.2002. PMC   6757947 . PMID   12122055.
• Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". Journal of Receptor and Signal Transduction Research. 22 (1–4): 79–110. doi:10.1081/RRS-120014589. PMID   12503609. S2CID   36697419.
• Katsel PL, Tagliente TM, Schwarz TE, Craddock-Royal BD, Patel ND, Maayani S (Feb 2003). "Molecular and biochemical evidence for the presence of type III adenylyl cyclase in human platelets". Platelets. 14 (1): 21–33. doi:10.1080/0953710021000062905. PMID   12623444. S2CID   7194996.
• Celano M, Arturi F, Presta I, Bruno R, Scarpelli D, Calvagno MG, Cristofaro C, Bulotta S, Giannasio P, Sacco R, Filetti S, Russo D (May 2003). "Expression of adenylyl cyclase types III and VI in human hyperfunctioning thyroid nodules". Molecular and Cellular Endocrinology. 203 (1–2): 129–135. doi:10.1016/S0303-7207(03)00086-8. PMID   12782409. S2CID   24573371.