GUCY1B3

GUCY1B1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WZ1, 3UVJ, 4NI2
Identifiers
Aliases	GUCY1B1 , guanylate cyclase 1, soluble, beta 3, GUCSB3, guanylate cyclase 1 soluble subunit beta, GC-SB3, GUC1B3, GC-S-beta-1, guanylate cyclase 1 soluble subunit beta 1, GUCB3, GUCY1B3
External IDs	OMIM: 139397; MGI: 1860604; HomoloGene: 664; GeneCards: GUCY1B1; OMA:GUCY1B1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q32.1 Start 155,758,992 bp [1] End 155,807,811 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 E3 Start 81,939,313 bp [2] End 81,981,996 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus orbitofrontal cortex lateral nuclear group of thalamus superior frontal gyrus Brodmann area 46 postcentral gyrus Brodmann area 23 pars compacta pons entorhinal cortex Top expressed in olfactory tubercle habenula lateral septal nucleus anterior amygdaloid area globus pallidus left lung lobe ventromedial nucleus dorsomedial hypothalamic nucleus dorsal tegmental nucleus mammillary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding guanylate cyclase activity GTP binding metal ion binding protein binding heme binding lyase activity phosphorus-oxygen lyase activity signaling receptor activity adenylate cyclase activity Cellular component plasma membrane guanylate cyclase complex, soluble cytoplasm presynaptic active zone Biological process intracellular signal transduction cyclic nucleotide biosynthetic process blood circulation nitric oxide-cGMP-mediated signaling pathway cGMP biosynthetic process nitric oxide mediated signal transduction cellular response to nitric oxide cGMP-mediated signaling trans-synaptic signaling by nitric oxide, modulating synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2983 54195 Ensembl ENSG00000061918 ENSMUSG00000028005 UniProt Q02153 O54865 RefSeq (mRNA) NM_000857 NM_001291951 NM_001291952 NM_001291953 NM_001291954 NM_001291955 NM_001161796 NM_017469 RefSeq (protein) NP_000848 NP_001278880 NP_001278881 NP_001278882 NP_001278883 NP_001278884 NP_001155268 NP_059497 Location (UCSC) Chr 4: 155.76 – 155.81 Mb Chr 3: 81.94 – 81.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene. ^{[5] [6]}

Function

Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs. ^[6]

Interactions

GUCY1B3 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1 ^[7] and Endothelial NOS. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000061918 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028005 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Giuili G, Scholl U, Bulle F, Guellaën G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett. 304 (1): 83–8. Bibcode:1992FEBSL.304...83G. doi: 10.1016/0014-5793(92)80594-7 . PMID   1352257. S2CID   26032197.
6. "Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3".
7. Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD (Aug 2003). "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". Am. J. Physiol. Heart Circ. Physiol. 285 (2): H669–78. doi:10.1152/ajpheart.01025.2002. PMID   12676772.

Further reading

• Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP, Waldman SA (2000). "Guanylyl cyclases and signaling by cyclic GMP". Pharmacol. Rev. 52 (3): 375–414. doi:10.1016/S0031-6997(24)01457-1. PMID   10977868.
• Chhajlani V, Frändberg PA, Ahlner J, Axelsson KL, Wikberg JE (1991). "Heterogeneity in human soluble guanylate cyclase due to alternative splicing". FEBS Lett. 290 (1–2): 157–8. Bibcode:1991FEBSL.290..157C. doi: 10.1016/0014-5793(91)81248-7 . PMID   1680753. S2CID   35130409.
• Giuili G, Roechel N, Scholl U, Mattei MG, Guellaen G (1993). "Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33". Hum. Genet. 91 (3): 257–60. doi:10.1007/BF00218267. PMID   8097486. S2CID   24237232.
• Papapetropoulos A, Cziraki A, Rubin JW, Stone CD, Catravas JD (1996). "cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue". J. Cell. Physiol. 167 (2): 213–21. doi: 10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S . PMID   8613461. S2CID   25406282.
• Zabel U, Weeger M, La M, Schmidt HH (1998). "Human soluble guanylate cyclase: functional expression and revised isoenzyme family". Biochem. J. 335 (1): 51–7. doi:10.1042/bj3350051. PMC   1219751 . PMID   9742212.
• Russwurm M, Wittau N, Koesling D (2002). "Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes". J. Biol. Chem. 276 (48): 44647–52. doi: 10.1074/jbc.M105587200 . PMID   11572861.
• Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD (2003). "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". Am. J. Physiol. Heart Circ. Physiol. 285 (2): H669–78. doi:10.1152/ajpheart.01025.2002. PMID   12676772.
• Meurer S, Pioch S, Wagner K, Müller-Esterl W, Gross S (2005). "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase". J. Biol. Chem. 279 (47): 49346–54. doi: 10.1074/jbc.M410565200 . PMID   15381706.
• Mateos-Cáceres PJ, Garcia-Cardoso J, Lapuente L, Zamorano-León JJ, Sacristán D, de Prada TP, Calahorra J, Macaya C, Vela-Navarrete R, López-Farré AJ (2006). "Soluble guanylate cyclase beta1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction". Int. J. Impot. Res. 18 (5): 432–7. doi: 10.1038/sj.ijir.3901461 . PMID   16528291.