ADCY9

ADCY9
Identifiers
Aliases	ADCY9 , AC9, ACIX, adenylate cyclase 9
External IDs	OMIM: 603302; MGI: 108450; HomoloGene: 868; GeneCards: ADCY9; OMA:ADCY9 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p13.3 Start 3,953,387 bp [1] End 4,116,442 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16 A1|16 2.42 cM Start 4,105,393 bp [2] End 4,238,362 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Epithelium of choroid plexus vastus lateralis muscle myocardium of left ventricle gastrocnemius muscle glutes Skeletal muscle tissue of biceps brachii parotid gland deltoid muscle endothelial cell Top expressed in CA3 field Region I of hippocampus proper triceps brachii muscle sternocleidomastoid muscle temporal muscle primary motor cortex dentate gyrus vastus lateralis muscle Rostral migratory stream subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding metal ion binding lyase activity phosphorus-oxygen lyase activity ATP binding adenylate cyclase activity guanylate cyclase activity Cellular component membrane integral component of plasma membrane axon dendrite plasma membrane integral component of membrane guanylate cyclase complex, soluble intracellular anatomical structure Biological process intracellular signal transduction cellular response to glucagon stimulus cyclic nucleotide biosynthetic process adenylate cyclase-activating adrenergic receptor signaling pathway renal water homeostasis signal transduction cAMP biosynthetic process adenylate cyclase-activating G protein-coupled receptor signaling pathway cGMP biosynthetic process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway activation of adenylate cyclase activity activation of protein kinase A activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 115 11515 Ensembl ENSG00000162104 ENSMUSG00000005580 UniProt O60503 P51830 RefSeq (mRNA) NM_001116 NM_001291910 NM_009624 RefSeq (protein) NP_001107 NP_001278839 NP_033754 Location (UCSC) Chr 16: 3.95 – 4.12 Mb Chr 16: 4.11 – 4.24 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Adenylyl cyclase type 9 is an enzyme that in humans is encoded by the ADCY9 gene. ^{[5] [6]}

Function

Adenylyl cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000162104 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005580 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hacker BM, Tomlinson JE, Wayman GA, Sultana R, Chan G, Villacres E, Disteche C, Storm DR (Apr 1999). "Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9)". Genomics. 50 (1): 97–104. doi:10.1006/geno.1998.5293. PMID   9628827.
6. "Entrez Gene: ADCY9 adenylate cyclase 9".

External links

• Human ADCY9 genome location and ADCY9 gene details page in the UCSC Genome Browser .

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Paterson JM, Smith SM, Harmar AJ, Antoni FA (1995). "Control of a novel adenylyl cyclase by calcineurin". Biochem. Biophys. Res. Commun. 214 (3): 1000–8. Bibcode:1995BBRC..214.1000P. doi:10.1006/bbrc.1995.2385. PMID   7575502.
• Premont RT, Matsuoka I, Mattei MG, et al. (1996). "Identification and characterization of a widely expressed form of adenylyl cyclase". J. Biol. Chem. 271 (23): 13900–7. doi: 10.1074/jbc.271.23.13900 . PMID   8662814.
• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi: 10.1093/dnares/5.1.31 . PMID   9628581.
• Barcova M, Speth C, Kacani L, et al. (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Arch. 437 (4): 538–46. doi:10.1007/s004240050815. PMID   10089566. S2CID   7620262.
• Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS. 14 (6): 629–36. doi: 10.1097/00002030-200004140-00001 . PMID   10807185. S2CID   22105709.
• Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". J. Allergy Clin. Immunol. 105 (5): 975–82. doi: 10.1067/mai.2000.105315 . PMID   10808179.
• Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". J. Neurochem. 77 (2): 399–407. doi: 10.1046/j.1471-4159.2001.00249.x . PMID   11299302. S2CID   24053412.
• Toyota T, Hattori E, Meerabux J, et al. (2002). "Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders". Am. J. Med. Genet. 114 (1): 84–92. doi:10.1002/ajmg.10117. PMID   11840511.
• Speth C, Schabetsberger T, Mohsenipour I, et al. (2002). "Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons". J. Virol. 76 (7): 3179–88. doi:10.1128/JVI.76.7.3179-3188.2002. PMC   136041 . PMID   11884542.
• Toyota T, Yamada K, Saito K, et al. (2002). "Association analysis of adenylate cyclase type 9 gene using pedigree disequilibrium test in bipolar disorder". Mol. Psychiatry. 7 (5): 450–2. doi: 10.1038/sj.mp.4000992 . PMID   12082561.
• Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". J. Recept. Signal Transduct. Res. 22 (1–4): 79–110. doi:10.1081/RRS-120014589. PMID   12503609. S2CID   36697419.
• Small KM, Brown KM, Theiss CT, et al. (2004). "An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation". Pharmacogenetics. 13 (9): 535–41. doi:10.1097/00008571-200309000-00002. PMID   12972952.
• Cumbay MG, Watts VJ (2004). "Novel regulatory properties of human type 9 adenylate cyclase". J. Pharmacol. Exp. Ther. 310 (1): 108–15. doi:10.1124/jpet.104.065748. PMID   14996950. S2CID   6161734.
• Tantisira KG, Small KM, Litonjua AA, et al. (2005). "Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways". Hum. Mol. Genet. 14 (12): 1671–7. doi: 10.1093/hmg/ddi175 . PMID   15879435.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.