ADCY7

ADCY7
Identifiers
Aliases	ADCY7 , AC7, adenylate cyclase 7
External IDs	OMIM: 600385 MGI: 102891 HomoloGene: 866 GeneCards: ADCY7
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q12.1 Start 50,246,137 bp [1] End 50,318,135 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 C3|8 43.06 cM Start 88,999,031 bp [2] End 89,056,590 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood appendix secondary oocyte lymph node bone marrow cells spleen gallbladder placenta upper lobe of left lung Top expressed in ascending aorta aortic valve Paneth cell carotid body blood substantia nigra spleen conjunctival fornix condyle calvaria More reference expression data BioGPS More reference expression data
Gene ontology Molecular function adenylate cyclase activity ATP binding phosphorus-oxygen lyase activity metal ion binding nucleotide binding lyase activity guanylate cyclase activity Cellular component integral component of membrane membrane plasma membrane guanylate cyclase complex, soluble intracellular anatomical structure integral component of plasma membrane Biological process renal water homeostasis intracellular signal transduction cellular response to ethanol cellular response to glucagon stimulus cyclic nucleotide biosynthetic process maternal process involved in female pregnancy cGMP biosynthetic process signal transduction adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cAMP biosynthetic process adenylate cyclase-activating G protein-coupled receptor signaling pathway regulation of adaptive immune response cellular response to lithium ion negative regulation of cytokine production involved in inflammatory response activation of adenylate cyclase activity activation of protein kinase A activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 113 11513 Ensembl ENSG00000121281 ENSMUSG00000031659 UniProt P51828 P51829 RefSeq (mRNA) NM_001114 NM_001286057 NM_001037723 NM_001037724 NM_001109756 NM_007406 RefSeq (protein) NP_001105 NP_001272986 NP_001032812 NP_001032813 NP_001103226 NP_031432 Location (UCSC) Chr 16: 50.25 – 50.32 Mb Chr 8: 89 – 89.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Adenylyl cyclase type 7 is an enzyme that in humans is encoded by the ADCY7 gene. ^{[5] [6]}

Function

This gene encodes a membrane-bound adenylyl cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000121281 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031659 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hellevuo K, Berry R, Sikela JM, Tabakoff B (Mar 1995). "Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16". Hum Genet. 95 (2): 197–200. doi:10.1007/bf00209401. PMID   7860067. S2CID   35555146.
6. "Entrez Gene: ADCY7 adenylate cyclase 7".

External links

• Human ADCY7 genome location and ADCY7 gene details page in the UCSC Genome Browser .

Further reading

• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi: 10.1093/dnares/1.1.27 . PMID   7584026.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi: 10.1093/dnares/1.1.47 . PMID   7584028.
• Hellevuo K, Welborn R, Menninger JA, Tabakoff B (1997). "Human adenylyl cyclase type 7 contains polymorphic repeats in the 3' untranslated region: investigations of association with alcoholism". Am. J. Med. Genet. 74 (1): 95–8. doi:10.1002/(SICI)1096-8628(19970221)74:1<95::AID-AJMG19>3.0.CO;2-M. PMID   9034014.
• Barcova M, Speth C, Kacani L, et al. (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Arch. 437 (4): 538–46. doi:10.1007/s004240050815. PMID   10089566. S2CID   7620262.
• Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS. 14 (6): 629–36. doi: 10.1097/00002030-200004140-00001 . PMID   10807185. S2CID   22105709.
• Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". J. Allergy Clin. Immunol. 105 (5): 975–82. doi: 10.1067/mai.2000.105315 . PMID   10808179.
• Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". J. Neurochem. 77 (2): 399–407. doi: 10.1046/j.1471-4159.2001.00249.x . PMID   11299302. S2CID   24053412.
• Yan SZ, Tang WJ (2002). "Construction of Soluble Adenylyl Cyclase from Human Membrane-Bound Type 7 Adenylyl Cyclase". G Protein Pathways - Part C, Effector Mechanisms. Methods in Enzymology. Vol. 345. pp. 231–41. doi:10.1016/S0076-6879(02)45019-7. ISBN   978-0-12-182246-0. PMID   11665607.
• Speth C, Schabetsberger T, Mohsenipour I, et al. (2002). "Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons". J. Virol. 76 (7): 3179–88. doi:10.1128/JVI.76.7.3179-3188.2002. PMC   136041 . PMID   11884542.
• Nelson EJ, Hellevuo K, Yoshimura M, Tabakoff B (2003). "Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta". J. Biol. Chem. 278 (7): 4552–60. doi: 10.1074/jbc.M210386200 . PMID   12454008.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". J. Recept. Signal Transduct. Res. 22 (1–4): 79–110. doi:10.1081/RRS-120014589. PMID   12503609. S2CID   36697419.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Beeler JA, Yan SZ, Bykov S, et al. (2005). "A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase". Biochemistry. 43 (49): 15463–71. CiteSeerX   10.1.1.558.7519 . doi:10.1021/bi049088+. PMID   15581358.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Hines LM, Hoffman PL, Bhave S, et al. (2006). "A sex-specific role of type VII adenylyl cyclase in depression". J. Neurosci. 26 (48): 12609–19. doi: 10.1523/JNEUROSCI.1040-06.2006 . PMC   6674903 . PMID   17135423.