ADCY10

ADCY10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CLK, 4CLL, 4CLP, 4CLS, 4CLT, 4CLU, 4CLW, 4CLY, 4CLZ, 4CM0, 4CM2, 4OYA, 4OYB, 4OYI, 4OYM, 4OYO, 4OYP, 4OYW, 4OYX, 4OYZ, 4OZ2, 4OZ3, 4UST, 4USU, 4USV, 4USW, 5D0R Contents Function ; Clinical significance ; References ; External links ; Further reading ;
Identifiers
Aliases	ADCY10 , HCA2, SAC, SACI, Sacy, hsAC, HEL-S-7a, adenylate cyclase 10 (soluble), adenylate cyclase 10, soluble, adenylate cyclase 10
External IDs	OMIM: 605205 MGI: 2660854 HomoloGene: 10188 GeneCards: ADCY10
Gene location (Human)
Chr.	Chromosome 1 (human)
End	167,914,215 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	165,404,343 bp
RNA expression pattern
	Top expressed in
	sperm; ; right lobe of liver; ; cerebellar hemisphere; ; right coronary artery; ; islet of Langerhans; ; duodenum; ; Brodmann area 9; ; kidney; ; body of stomach; ; left ventricle;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; morula; ; proximal tubule; ; esophagus; ; carotid body; ; superior frontal gyrus; ; muscle tissue; ; neural tube;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; manganese ion binding ; metal ion binding ; lyase activity ; adenylate cyclase activity ; phosphorus-oxygen lyase activity ; bicarbonate binding ; ATP binding ; magnesium ion binding ; ATPase binding ;
Cellular component	cytoplasm ; cytosol ; cell projection ; membrane ; microtubule cytoskeleton ; growth cone ; basal part of cell ; plasma membrane ; apical part of cell ; cilium ; axon ; neuronal cell body ; dendrite ; mitochondrion ; perinuclear region of cytoplasm ; motile cilium ; cytoskeleton ; nucleus ; apical plasma membrane ; extracellular region ;
Biological process	cellular response to inorganic substance ; intracellular signal transduction ; epithelial cilium movement involved in extracellular fluid movement ; cyclic nucleotide biosynthetic process ; spermatogenesis ; positive regulation of apoptotic process ; cAMP biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	55811
	271639
	ENSG00000143199
	ENSMUSG00000026567
	Q96PN6
	Q8C0T9
	NM_001167749 ; NM_001297772 ; NM_018417
	NM_173029 ; NM_001357427
	NP_001161221 ; NP_001284701 ; NP_060887
	NP_766617 ; NP_001344356
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated February 21, 2023

Adenylyl cyclase 10 also known as ADCY10 is an enzyme that, in humans, is encoded by the ADCY10 gene.^[5]

Function

The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is localized in the cytoplasm and is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction.^[6]

Clinical significance

Mutations in the ADCY10 gene are associated with an increased risk of adsorptive hypercalciuria.^[5]

Related Research Articles

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Soluble adenylyl cyclase (sAC) is a regulatory cytosolic enzyme present in almost every cell. sAC is a source of cyclic adenosine 3’,5’ monophosphate (cAMP) – a second messenger that mediates cell growth and differentiation in organisms from bacteria to higher eukaryotes. sAC differentiates from the transmembrane adenylyl cyclase (tmACs) – an important source of cAMP; in that sAC is regulated by bicarbonate anions and it is dispersed throughout the cell cytoplasm. sAC has been found to have various functions in physiological systems different from that of the tmACs.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000143199 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026567 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Reed BY, Heller HJ, Gitomer WL, Pak CY (November 1999). "Mapping a gene defect in absorptive hypercalciuria to chromosome 1q23.3-q24". J. Clin. Endocrinol. Metab. 84 (11): 3907–13. doi: 10.1210/jcem.84.11.6155 . PMID 10566627.
↑ "Entrez Gene: ADCY10".

External links

Human ADCY10 genome location and ADCY10 gene details page in the UCSC Genome Browser .

Hukovic N, Panetta R, Kumar U, et al. (1998). "The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization". J. Biol. Chem. 273 (33): 21416–22. doi: 10.1074/jbc.273.33.21416 . PMID 9694905.
Buck J, Sinclair ML, Schapal L, et al. (1999). "Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals". Proc. Natl. Acad. Sci. U.S.A. 96 (1): 79–84. Bibcode:1999PNAS...96...79B. doi: 10.1073/pnas.96.1.79 . PMC 15096 . PMID 9874775.
Hayes JS, Lawler OA, Walsh MT, Kinsella BT (1999). "The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling". J. Biol. Chem. 274 (34): 23707–18. doi: 10.1074/jbc.274.34.23707 . PMID 10446129.
Sinclair ML, Wang XY, Mattia M, et al. (2000). "Specific expression of soluble adenylyl cyclase in male germ cells". Mol. Reprod. Dev. 56 (1): 6–11. doi:10.1002/(SICI)1098-2795(200005)56:1<6::AID-MRD2>3.0.CO;2-M. PMID 10737962. S2CID 34539645.
Chen Y, Cann MJ, Litvin TN, et al. (2000). "Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor". Science. 289 (5479): 625–8. Bibcode:2000Sci...289..625C. doi:10.1126/science.289.5479.625. PMID 10915626.
Jaiswal BS, Conti M (2001). "Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase". J. Biol. Chem. 276 (34): 31698–708. doi: 10.1074/jbc.M011698200 . PMID 11423534.
Reed BY, Gitomer WL, Heller HJ, et al. (2002). "Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density". J. Clin. Endocrinol. Metab. 87 (4): 1476–85. doi: 10.1210/jc.87.4.1476 . PMID 11932268.
Zippin JH, Chen Y, Nahirney P, et al. (2003). "Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains". FASEB J. 17 (1): 82–4. doi:10.1096/fj.02-0598fje. PMID 12475901. S2CID 22099561.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Litvin TN, Kamenetsky M, Zarifyan A, et al. (2003). "Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate". J. Biol. Chem. 278 (18): 15922–6. doi: 10.1074/jbc.M212475200 . PMID 12609998.
Jaiswal BS, Conti M (2003). "Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 100 (19): 10676–81. Bibcode:2003PNAS..10010676J. doi: 10.1073/pnas.1831008100 . PMC 196863 . PMID 12958208.
Marjanovic JA, Li Z, Stojanovic A, Du X (2006). "Stimulatory roles of nitric-oxide synthase 3 and guanylyl cyclase in platelet activation". J. Biol. Chem. 280 (45): 37430–8. doi: 10.1074/jbc.M506518200 . PMID 16144836.
Schmid A, Sutto Z, Nlend MC, et al. (2007). "Soluble Adenylyl Cyclase Is Localized to Cilia and Contributes to Ciliary Beat Frequency Regulation via Production of cAMP". J. Gen. Physiol. 130 (1): 99–109. doi:10.1085/jgp.200709784. PMC 2154360 . PMID 17591988.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000143199 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026567 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10566627-5] 1 2 Reed BY, Heller HJ, Gitomer WL, Pak CY (November 1999). "Mapping a gene defect in absorptive hypercalciuria to chromosome 1q23.3-q24". J. Clin. Endocrinol. Metab. 84 (11): 3907–13. doi: 10.1210/jcem.84.11.6155 . PMID 10566627.

[entrez-6] "Entrez Gene: ADCY10".

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)